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Antifungal effect of
Calotropis procera stem bark on Epidermophyton flocosum
and Trichophyton gypseum
F. A. Kuta
Department
of Microbiology, Federal University of Technology, Minna,
Nigeria. E-mail:
kutafaruk@yahoo.com.
Accepted
6 May, 2008 |
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The antifugal activities of aqueous extract of Calotropics
procera was determined against Epidermophyton
flocosum and Tricophyton gypseum using agar
diffusion techniques. The crude extract of C. procera
showed activity on E. flocosum and T. gypseum
at 4.0 mg/ml. The result of minimum inhibitory concentration
(MIC) was 0.5 and 0.9 mg/ml and that of minimum fungicidal
concentration (MFC) was 2.0 and 4.0 mg/ml, respectively. The
result of the Ames test indicated that the crude extract is
not mutagenic. Phytochemical screening of the crude extract
revealed the presence of saponin, tannins, sequiterpene and
alkaloids. The results of the study suggest that C.
procera stem could be a potential source of
chemotherapeutic drugs for the treatment of tinea associated
with E. flocosum and T. gypseum.
Key
words:
Calotropis procera, Epidermophyton flocosum,
Trichophyton gypseum, mutagencity. |
