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Hepatoprotective and some haematological effects of
Allium sativum and vitamin C in lead-exposed Wistar rats
G. O. Ajayi1,2, T. T.
Adeniyi1* and D. O. Babayemi1
1Department
of Biochemistry, College of Natural Sciences, University of
Agriculture, P. M. B. 2240, Abeokuta, Ogun State, Nigeria.
2Department
of Medical Biochemistry, Faculty of Basic Medical Sciences,
Lagos State University College of Medicine, P. M. B. 21266,
Ikeja, Lagos, Nigeria.
*Corresponding author. E-mail:
ttadeniyi@yahoo.com.
Tel.: +234-803-389-2442.
Accepted 12 February, 2009 |
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The hepatoprotective and some haematological effects of
Allium sativum (Garlic) and vitamin C were studied on
experimental rats that were exposed to lead (Pb) for one
week. Twenty – four female Wistar rats were divided into
four groups of six rats per group. Rats in group A were kept
as the control. Rats in groups B, C and D were exposed to
100 µmol/kg body weight of lead acetate intraperitoneally
for seven days. Garlic diet (200 g minced garlic/kg diet)
and vitamin C (500 mg/kg body weight) were given to rats in
groups C and D for additional seven days respectively.
Garlic and vitamin C produced significant reduction at p <
0.05 in the levels of ALT, ALP and PCV while the level of
AST increases significantly at p < 0.05. The level of Hb
increases significantly at p < 0.05 in rats treated with
garlic and reduces significantly at p < 0.05 in rats treated
with Vitamin C. This study, therefore suggests that garlic
and vitamin C have some hepatoprotective and haematological
effects.
Key words:
Hepatoprotective, haematological, Allium sativum,
vitamin C, Lead (Pb). |
