Abbreviation: J. Biophys. Struct. Biol.
Start Year: 2009
Page 1 of 2, showing 20 records out of 22 total, starting on record 1, ending on 20
DOI: 10.5897/JBSB2016.0057[Article Number: 48F63E566015]
An allometric target organ dose model (TOD-Wb) with variable scaling exponent, b = br + bo(bm) - bi, is proposed for the extrapolation of animal toxicity to human. The exponent b comprises four constituent parameters representing the intake mode to entry organ (bi), route of transportation to target organ (br), mass of target organ (bo), and rate of metabolism at target organ (bm). This expression enables the a priori... Read more.
DOI: 10.5897/JBSB2013.0045[Article Number: 337345B44936]
Under physiological conditions, interaction between ceftriaxone and human serum albumin was investigated by using fluorescence spectroscopy and ultra violet (UV) absorption spectrum. From spectral analysis, ceftriaxone showed a strong ability to quench the intrinsic fluorescence of human serum albumin (HSA) through a static quenching procedure. The binding constant (k) is estimated as K=1.02× 103 M-1 at 298 K.... Read more.
DOI: 10.5897/JBSB11.002[Article Number: 5E917DE10946]
Type 2 diabetes mellitus (T2DM) is the most common metabolic disease in theworld, reaching epidemic proportions. PPARGC1A mRNA expression is reduced in islets from patients with diabetes 2 and it is influenced by both genetic and epigenetic factor. The epigenetic modification, results as a two fold increase in DNA methylation of the PGC1A promoter of diabetes. This two fold increase in DNA methylation is due to the DNA... Read more.
DOI: 10.5897/JBSB2012.005[Article Number: 0E5387640425]
This work was performed with smokers of Virginia tobacco cigarettes without taking into consideration brand or type of cigarettes. An experimental study was conducted for the variation of cigarettes number and the increments in airway resistance for both normal and respiratory disordered subjects using body plethysmograph for testing individuals. Seventeen (17) nonsmokers and ten smokers were studied. The investigation... Read more.
DOI: 10.5897/JBSB11.010[Article Number: 869F30E10933]
The paper is aimed at presenting the differential equations for the cardiovascular system with the help of continuity equation of fluid mechanics to reduce the abnormality of the rate of blood flow and variation of blood volume in different parts of the system. The equations are used to explain the Frank-Starling mechanism, which plays an important role in the maintenance of the stability of the distribution of blood in... Read more.
DOI: 10.5897/JBSB12.002[Article Number: 473AD5E10939]
Sonophoresis is the using of ultrasound waves to increase the entrancement of genes and drugs surpassing the skin barrier. Many mechanisms have been described to illustrate the sonophoresis mode of action; some describe changes in skin resistance during sonophoresis. Electrical impedance tomography (EIT) technique uses voltage measurement through a group of electrodes and reconstructs the data to a conductivity picture.... Read more.
DOI: 10.5897/JBSB11.008[Article Number: 9C9A69A10916]
Protein arginine methyltransferases (PRMTs) function in the alkaline milieu of the nucleus and at neutral pH of the cytosol. Accordingly, several PRMTs are broadly active over a range of pHs. We investigated the effect altering pH had on protein arginine methylation using a variety of defined substrates, recombinant PRMTs and cell extracts.We demonstrate that pH-induced alterations in the extent of methylation and the... Read more.
DOI: 10.5897/JBSB11.009[Article Number: 6A0374B10924]
The chaperonin GroEL adopts a double-ring structure with various modes of allosteric communication. The simultaneous positive intra-ring and negative inter-ring cooperativities allow alternating functionality of the folding cavities in both protein rings. Mutation of glutamic acid 434 (located at the ring interface), to lysine alters the negative inter-ring cooperativity. The crystal structure of the mutant chaperonin... Read more.
[Article Number: 85D4DDB10897]
Chaperone-like activity (CLA) of α-crystallin is known to be compromised in diabetic conditions and associated with cataract formation. Protecting α-crystallin CLA may help in delaying and/or preventing cataracts. In this study, we employed a lens organ culture model to study the effect of hyperglycemia on the CLA of α-crystallin and investigated the protective effect the tannoids... Read more.
[Article Number: 1A5A0C310908]
Ribonucleotide reductase (RR) is a ubiquitous cytosolic enzyme required for DNA synthesis and repair in all living cells. Therefore, the crucial role of this enzyme in cell division makes it a potential target for designing drugs that inhibit cell growth for cancer therapy. An increased interest in RR as a target for cancer therapy has been documented since the discovery that human RR is regulated by p53 enzyme and that... Read more.
[Article Number: 39E13B910812]
Plants growth is impressed by biotic and abiotic stress inversely. There are many reports about proteins change level in salinity stress. Leaves fill up more soluble sugar of glucose, fructose and proline with treatment of salicylic acid. In this research, tomato seeds planted in pots containing perlite were put in a growth chamber under controlled conditions of 27 ± 2 and 23 ± 2°C temperature, 16... Read more.
[Article Number: 575130110880]
Overexpressed autofluorescent-tagged versions of the Fragile mental retardation protein (FMRP) such as EGFP-FMRP have been used in protein-protein interaction studies and in studies of the composition, the formation and the localization of neuronal granules. However, the question of whether these molecules... Read more.
[Article Number: D6DA05E10890]
Pathogenic bacteria that cause infectious disease are operated by various virulence mechanisms. Hence, it is important to develop a reliable system for predicting bacterial virulent proteins aiming at discovering novel drug/vaccine and for understanding virulence mechanisms in pathogens. On the basis of features like amino acid and dipeptide composition, it tried to identify the virulence potential in the given... Read more.
[Article Number: 41932D740632]
A number of anti-HIV agents act by inhibiting specific steps in the lifecycle of HIV. Inhibition of reverse-transcriptase (RT), a multi-functional enzyme is an important option. The interaction of 2, 2´-(Diazinodimethylidyne)-di-(o-phenylene)-dibenzoate (HZ) with HIV1-RT was studied to explore its possible use in anti-HIV therapy. This novel hydrazine derivative undergoes strong interaction with a number of... Read more.
[Article Number: 8C1BE0C40644]
Structural studies suggest that the c-Abl protein kinase domain exists in two conformations; an active and an inactive form. There are many inhibitors which bind this tyrosine kinase in both forms. Many of these kinase inhibitors are in clinical trials too. The inhibition potency of these inhibitors is a common topic of discussion. In the present study we have taken a library of eight different inhibitors and docked... Read more.
[Article Number: 5D5103F10807]
In human physiological and pathological flow systems, it is not possible to rule out diffusion in all advective processes because perfusion goes hand in hand with diffusion processes. It is the perfusion throughout the capillary bed and then the diffusion of fluids throughout the tissue that is the subject of most magnetic resonance functional imaging procedures. It is observed from literature that basic theory of... Read more.
[Article Number: 402F89E10784]
The elemental composition of spore wall of arbuscular mycorrhizal fungi (AMF) was analyzed by energy-dispersive X-ray spectrometry (EDS) in a preliminary assessment. Measurements of AMF spores were made for riparian soils in both urban (rivers subjected to different human activities) and farm sites in southeastern Brazil. Spore populations belonging to four... Read more.
[Article Number: D3301F210795]
Changes in growth parameters and 14C02 and [U-14C]-sucrose incorporation into the primary metabolic pools and diterpene 10 DAB compound were investigated in leaves and stems of Taxus wallichiana Zucarnii treated with gibberellic acid (GA) and inoculated with arbuscular mycorrhizae (AM). Compared to the control, GA(1000 ppm) and AM (1 kg/ha each) with AM-GA combined treatments, induced... Read more.
[Article Number: 4D568DE10753]
Addition of the organophosphorous plant growth regulator - melafen to the mitochondria incubation medium resulted in modification of energy thereof. The modification was dose dependent one. The melafen concentrations 2 × 10-12, 2 ×10-18 and 2 × 10-21 М raised the maximum rates for oxidation of NAD+-dependent substrates, elevated the efficiency of oxidative... Read more.
[Article Number: 6AB8EDC40590]
The objective of this study was to determine the instantaneous arterial blood pressure by the peripheral bio-impedance. To achieve this goal, the equation of Ben Salah and Flaud, initially meant to determine the instantaneous aortic pressure according to the signal of thoracic bioimpedance, was successfully applied for the determination of the instantaneous arterial pressure according to the signal of peripheral... Read more.
Page 1 of 2, showing 20 records out of 22 total, starting on record 1, ending on 20