Abbreviation: J. Cancer Res. Exp. Oncol.
Start Year: 2009
Page 1 of 3, showing 20 records out of 51 total, starting on record 1, ending on 20
DOI: 10.5897/JCREO2017.0147[Article Number: 18B12D265483]
Myriad roles of mucins in normal tissues have been well documented, including lubrication of the epithelial surfaces; protection from physical damage; facilitation in cell-cell signaling and suppression of inflammatory activity. Pathological expression of mucins has been noted in cancer development and progression. This study sought to identify and quantify the types of mucins produced during various histological grades... Read more.
DOI: 10.5897/JCREO2017.0146[Article Number: AB0BAA364455]
A retrospective study of gastrointestinal tract (GIT) tumors of humans in Zaria was carried out to determine the prevalence rates. Of the 124 human cases recorded in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, 39 (31.45%) had upper GIT tumors while 42 (33.87%) had tumors located in the lower GIT. All age groups were affected. The risk for developing tumors increased with age in cases studied. The affected... Read more.
DOI: 10.5897/JCREO2016.0135[Article Number: 45A6D2360297]
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio in diagnosis of HCC in Egyptian patients with chronic... Read more.
DOI: 10.5897/JCREO2016.0129[Article Number: AD8630160299]
Lymphedema of the arm and/or hand is a long-term complication of breast cancer treatment. Accurate estimates of the incidence and prevalence of lymphedema are lacking, as are the effects of this condition on overall quality of life. The objective of this study was to determine the prevalence of unilateral arm lymphedema among breast cancer patients one year after completion of treatment at Cancer Diseases... Read more.
DOI: 10.5897/JCREO2016.0128[Article Number: 7F63AAF59773]
This study aims to determine health-related quality of life (HRQOL) of breast cancer patients with unilateral arm lymphedema one year after completion of treatment at Cancer Diseases Hospital. The study design comprises of a cross sectional study, where we assessed the HRQoL controlling for patient demographics, cancer stages and treatment types. Short form of 36 interview schedule was used to assess HRQol and to... Read more.
DOI: 10.5897/JCREO2015.0124[Article Number: 9EECDCA59698]
The endeavor of this paper was to review cancer immunotherapy which means the modulating and using of the patient’s own immune system to target the cancer cells rather than using an extrinsic means of therapy. The best way to prevent and remove infections is through the natural 'sterilising' action of the immune response that combines elements of both innate and adaptive immunity to ward off foreign... Read more.
DOI: 10.5897/JCREO2016.0127[Article Number: 3FFE5EC58494]
The present work was conducted to perform a short-term comparative analysis and evaluate the anti-neoplastic effects of diallyl disulfide on rectal carcinogenicity via histopathological changes, chromosomal aberrations, and mitotic index induced by 1,2-dimethylhydrazine on male rabbits (Orectolagus cuniculus). The histological changes that can be seen microscopically showed that 1,2-dimethylhydrazine at the suggested... Read more.
DOI: 10.5897/JCREO2015.0122[Article Number: DF340B655106]
In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. The primary aim of this study is to evaluate the clinicopathological and survival significance of BAT-25 and BAT-26 instability, in 60 patients with breast cancer.... Read more.
DOI: 10.5897/JCREO2014.0117[Article Number: 9167B5A51220]
Cancer is a leading cause of death worldwide, resulting in 8.2 million or 14.6% of all human deaths worldwide in 2012. More than 70% of all cancer deaths occurred in low and middle income countries; although the risk of developing/dying from it is still higher in the developed regions of the world, and tobacco use is the cause of about 22% of cancer deaths which is still a major public health problem worldwide that... Read more.
DOI: 10.5897/JCREO2014.0114[Article Number: 793A14C49330]
Gynaecological or cervical cancer remains a significant public health problem worldwide, a situation from which Ghana is not exempt. Human papilloma virus (HPV) is an important agent of pre-invasive and invasive cervical cancer. Currently, over 70 genotypes of the virus have been identified, of which twenty or more have actually been isolated from or are reportedly associated with female genital lesions. Anecdotal... Read more.
DOI: 10.5897/JCREO2014.0115[Article Number: F43FA2947551]
After witnessing two cancer deaths in my family, I understood how hard it is for a family to bear the loss. So I strongly feel that a planned approach towards prevention and elimination of cancer, and especially lifestyle related cancers, is the need of the hour in developing nations where resources are limited. A large proportion of a nation’s population is comprised of young adults. They can make a huge... Read more.
DOI: 10.5897/JCREO2014-0109[Article Number: F9CAFC146729]
Undifferentiated (World Health Organization (WHO) 3) type of nasopharyngeal cancer (NPC) is strongly correlated with Epstein-barr (EBV) virus latent infection. Post-treatment viral reactivation is associated with relapsed or recurrence of NPC. Viral activation can be measured indirectly via plasma IgA responses towards EBV proteins such as EBNA1 and VCA-p18. This study aims at determining the prognostic value of... Read more.
DOI: 10.5897/JCREO2013.0105[Article Number: 9DAF62446732]
Omega-3 essential fatty acids (ω-3 FATs); found in the highest concentrations in fish oil, claim a plethora of health benefits. The present study aims to evaluate the biological effects of ω-3 FATs supplementation against Ehrlich carcinoma (EC) induced inflammation, oxidative stress, biochemical and histopathological alterations in the liver tissue of albino mouse. ω-3 FATs were orally administered via... Read more.
DOI: 10.5897/JCREO11.046[Article Number: DB3BC0942284]
This study aimed to evaluate the therapeutic yield of levonorgestrel-releasing intrauterine device (LNG-IUD) for management of tamoxifen induced menorrhagia in women who had mastectomy for treatment of breast cancer. This study included 34 patients who had breast cancer, underwent mastectomy, were maintained on tamoxifen post-operatively for at least 6 months, and had also newly developed menorrhagia throughout their... Read more.
DOI: 10.5897/JCREO11.042[Article Number: 22BD42C42283]
Hypertrophic pulmonary osteoarthropathy (HOA) is a disabling condition that may occur secondarily to primary lung carcinoma. Management of joint pain in patients with HOA is challenging, and treatment options are experimental. Here we report an unusual case of HOA in a 54 year-old man who presented with fever, rash and arthralgia as initial symptoms of an underlying non-small cell lung cancer. He did not respond to... Read more.
DOI: 10.5897/JCREO2013.0101[Article Number: 98D395841018]
Molecular characterization of PCa and BPH using the angiogenic tissue markers CD31 and CD45 to differentiate between the two major types of prostate gland disorders is investigated. 8 clinically characterized biopsies were analyzed at the Histopathology Laboratory of the Ekiti State University Teaching Hospital; the tissue sections were processed for antigen retrieval and were labeled with anti-CD45 and... Read more.
DOI: 10.5897/JCREO2013.0102[Article Number: AF3E1A241025]
Naturally isolated cyclic pentapeptide Longicalycinin A, which showed cytotoxicity to Hep G2 cancer cell line with an IC50 value 13.52 μg/mL, has been successfully synthesized by solid-phase methodology with Fmoc/t-Bu protecting schemes via solution-phase macrocyclization. 2-chlorotrityl chloride resin was used as solid support. Solution phase macrocyclization of linear pentapeptide precursor was carried out by two... Read more.
DOI: 10.5897/JCREO11.041[Article Number: 0AB495A4235]
Chemotherapy is playing an important role in treating pancreatic cancer, either when used alone or when combined with surgery and radiotherapy. We summarized 80 eligible clinical trials published from January in 2006 to June in 2011 and discussed the future development of chemotherapy in the treatment of pancreatic cancer. All the clinical trials were divided into 5 groups: single-agent regimen (14 trials), binary... Read more.
DOI: 10.5897/JCREO12.004[Article Number: 53C20BE4242]
This research was done to examine the interaction of lectins with glycoconjugates expressed on Primary CNS tumors using lectins from marine algal Bryothamnion seaforthii(BSL) and seeds of Erythrina velutina (EVL) Fluorescein isothiocyanate (FITC)-labeled. Samples of different tumor types obtained from the Neurology Service of Sobral-Brazil were processed for histopathologic... Read more.
DOI: 10.5897/JCREO11.049[Article Number: 18035724090]
Estrogen receptor beta (ERβ) is predicted to play an important role in prevention of breast cancer development and metastasis. Phosphorylation of Estrogen receptor alpha (ERα) has been proven to be involved in the progression of breast cancer and it is believed oestrogen receptor beta too phosphorylated at multiple sites within the protein upon ligand binding although the exact function of this... Read more.
Page 1 of 3, showing 20 records out of 51 total, starting on record 1, ending on 20