Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007

JMPR Articles

June 2018

The “Doctrine of Signatures” in herbal prescriptions in Ikale and Ilaje communities of Ondo State, Southwestern Nigeria

The knowledge and application of the notion of “doctrine of signatures or correspondences” was evaluated among the Ikale and Ilaje people of Ondo State, Southwestern Nigeria. Information was solicited by administering questionnaires to one hundred and five (105) informants. Periodic field observations were also made. The research yielded 60 plants belonging to 37 families. The plants have characteristics...

Author(s): Aworinde David Olaniran, Erinoso Sakiru Morenikeji, Ogundele Alimi Adeyemi, Teniola Olasimbo Anuoluwapo and Ojo Samuel Omoniyi

June 2018

Ameliorative effects of glabridin on the structure and function of pancreas in streptozotocin-induced diabetic rats

Several studies highlight beneficial effect of glabridin as an anti-hyperglycemic agent. However, the protective mechanisms of glabridin on improvement of pancreatic islets damage due to streptozotocin (STZ) exposure have not been adequately investigated. In the present study, we aimed to elucidate the effects of glabridin on restoration of pancreatic islet architecture, at least in part by restoring collagen I and...

Author(s): Jongdee Nopparat, Wipapan Khimmaktong, Paweena Sanpradit and Rapeepan Kongnual

June 2018

An ethno-veterinary survey of medicinal plants used to treat bacterial diseases of livestock in three geographical areas of the Eastern Cape Province, South Africa.

An ethno-veterinary survey of plants used to treat certain bacterial diseases of livestock in three geographical areas of the Eastern Cape was conducted during 2013 to 2014. A purposive sampling technique was carried out using a semi-structured questionnaire and field observations to document indigenous knowledge in 48 communal households. From the respondents of the 48 households, 64.6% men and 35.4% women were...

Author(s): S. Mthi, J.M. Rust, T.L. Morgenthal and B. Moyo

June 2018

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

Hyraceum (HM) is used in traditional medicine in Southern Africa. Three concentrations of HM (mg/ml in distilled water) (0.0156, 0.03125 and 0.0625) were assessed for cytotoxicity (CT), genotoxicity (GT) and modulation of cyclophosphamide (CP)- and ethyl methanesulfonate (EMS)-induced GT using the Allium cepa assay following 24 h treatment.  CP (1.00 mg/ml) and EMS (0.0375 mg/ml) were not cytotoxic but genotoxic....

Author(s): Asita Okorie Asita, Thabang Rants’o, Sibusisiwe Magama and Matsepo Taole  

June 2018

Acute toxicity evaluation of ethanol extract of red algae, Osmundaria obtusiloba, in BALB/c mice

The genus Osmundaria (Rhodophyta, Ceramilaes, Rhodomelaceae) comprises tropical and temperate regions red marine seaweeds species. Osmundaria obtusiloba is distributed from the northeastern coast of Brazil to the state of Rio de Janeiro. Studies with ethanol extract of red seaweed O. obtusiloba showed the antiviral potential of this alga. Hence, this study examined in BALB/c mice the acute toxicity after oral...

Author(s): Caroline de Souza Barros, Max Willian Lisboa Gomes, Rafaela dos Santos Pereira Gomes, Vanessa Melchiades, Caio Cesar Richter Nogueira, Claudio César Cirne-Santos, Valeria Garrido, Carla Eponina Carvalho Pinto, Valeria Laneuville Teixeira and Izabel Christina Nunes de Palmer Paixão  

May 2018

In vitro antioxidant and antimicrobial activities of Pistacia lentiscus, Phyllanthus anderssonii and Cinnamomum verum crude extracts and fractions

In this study, phytochemical screening, antioxidant and antimicrobial activities of ethanolic (80%) extracts from leaf and stem of Pistacia lentiscus and Phyllanthus anderssonii and leaf of Cinnamomum verum and their fractions were evaluated. Antimicrobial activity was performed by disc diffusion method. The antioxidant activity was determined by stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical method....

Author(s): Emtinan A. Alhadi, Omer A. A. Hamdi, Saad M. H. Ayoub and Sakina Yagi  

May 2018

Indigenous knowledge on medicinal plants used in and around Robe Town, Bale Zone, Oromia Region, Southeast Ethiopia

A study on medicinally important plants in and around Robe town, Southwest Ethiopia was been carried out to document the medicinal plants and the associated knowledge in the area. Thirty informants with age range between 18 and 70 years took part in this study. Semi-structured interview was used to collect the data from the informants. The collected data was then analyzed using micro-soft excel spread sheet 2007 and...

Author(s): Abadi Birhanu and Shimels Ayalew  

May 2018

Phytochemical screening and peroxide value determination of methanolic extract of four traditional medicinal plants from Debre Tabor Town, Ethiopia

Medicinal plants have bioactive compounds which are used for curing of various human diseases and also play an important role in healing of different disease. Terpenoids, flavonoids, alkaloids, tannins are some of bioactive compounds present in different parts of medicinal plants. Qualitative identification of bioactive compounds and antioxidant activity determination of crude extracts of the leaves of four different...

Author(s): Limenew Abate and Tadesse Mengistu

May 2018

Antibacterial activity of endophytic fungi isolated from Croton lechleri (Euphorbiaceae)

Croton lechleri is a native species from the Amazon and used with relative frequency in folk medicine in Brazil and other countries. Diversity and antibacterial activity of endophytic fungi associated with this plant were studied here. Samples of leaves and stems were used and 575 endophytic fungi were isolated (307 from leaves and 268 from stems), comprising 284 morphotypes distributed in 13 genera and unknown. The...

Author(s): Sebastião Luiz Pires Vargas, Erlan Kessyo Braga de Albuquerque; Sandra Albuquerque Lima Ribeiro; Atilon Vasconcelos de Araujo, Renildo Moura da Cunha and Clarice Maia Carvalho  

May 2018

Antibacterial activity of endophytic fungi from the medicinal plant Uncaria tomentosa (Willd.) DC

This study was designed to determine the diversity and antibacterial activity of endophytic fungi isolated from Uncaria tomentosa. Leaf and stem were disinfected superficially and inoculated in PDA and SDA medium, with and without plant extract and incubated at 18 and 28°C for isolation of endophytic fungi. Endophytic fungi were inoculated in BD medium and the metabolites extracted with ethyl acetate. Endophytic...

Author(s): Rodrigo Asfury Rodrigues, Atilon Vasconcelos de Araujo, Renildo Moura da Cunha and Clarice Maia Carvalho  

April 2018

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats.  Rats were given graded doses (200, 400, 600 and 800 mg kg-1) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular...

Author(s): Victoria Adam Maina, Innocent Damudu Peter, Dauda Yahi, Umar Kyari Sandabe and Godwin Onyeamaechi Egwu  

April 2018

Isolation, characterization and biological activity of organic extractives from Calodendrum capense (L.f.) Thunb.(Rutaceae)

A novel prenylfuroquinoline alkaloid capensenin (1), an alkaloid confusameline (2), two furanocoumarins psolaren (3) and bergapten (4), were isolated from hexane and dichloromethane crude extracts of stem bark, leaves and fruit pericarp of Calodendrum capense. Limonin (5) was also isolated from the stem bark, while limonin diosphenol (6) was isolated from the seeds. Capensenin (1) showed weak antimicrobial activity...

Author(s): Okwemba R. I., Tarus P. K., Machocho A. K., Wanyonyi A. W., Waweru, I. M.,  Onyancha J. M., Onani M. O. and Amuka O.

March 2018

Characterization and antioxidant properties of crude water soluble polysaccharides from three edible mushrooms

In the present study three species of mushrooms, Auricularia auricula (AAP), Lentinus edodes (LDP, Shiitake mushroom) and Poria cocos (PCP) were isolated water soluble polysaccharides, and their antioxidant properties and chemical characteristics were evaluated. Fourier Transform-infrared analysis demonstrated that three polysaccharides were composed of β-glycoside linkages 3304 to 1000 cm-1, and continued until...

Author(s): Ashfaque Ahmed Khaskheli, Shahzor Gul Khaskheli, Ying Liu, Saghir Ahmed Sheikh, Yan-Feng Wang, Mamoun A. Homaida, Aijaz Hussain Soomro, Dong Xiao bo, Abdul Ghani Dars, Javaid Ahmed Lakho, Si Hu and Wen Huang

March 2018

Bioefficacy of Duranta erecta leaf extract on yellow fever and dengue vector, Aedes aegypti Linn. in Nigeria

Mosquitoes are considered as a major problem in public health. Control measures mainly by chemical insecticides, have led to several environmental and health problems in addition to development of resistance. The bioefficacy of aqueous extract of leaves of Duranta erecta against the yellow fever and dengue vector, Aedes aegypti was evaluated as a step towards developing a safe and eco-friendly agent to combat the...

Author(s): Agwu Ekenma Julia, Odo Ejikeme Gregory, Ekeh Felicia, Uwagbae Michael, Ngwu Godwin and Ehilegbu Chinelo  

March 2018

In vitro antiviral activity of Brazilian Cerrado plant extracts against animal and human herpesviruses

The Brazilian savanna known as “Cerrado” is very rich in medicinal plants that are used by the local population for treatment of several illnesses. The herpesvirus is a serious problem worldwide, and affects both animal and human health. This work aimed to study the antiviral activity of eight extracts from plants natives of “Cerrado” region against human (HSV-1), equine (EqHV-1) and swine...

Author(s): Marina A. Padilla, Isabela C. Simoni, Verônica Moreira H. Hoe, Maria Judite B. Fernandes, Clarice W. Arns, Juliana R. Brito and João Henrique G. Lago  

March 2018

Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens

The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as...

Author(s): Marco Antonio Costa, Andressa Blainski,  Vanessa Kaplum, Marli Miriam de Souza Lima, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, João Carlos Palazzo de Mello and Celso Vataru Nakamura  

March 2018

Acute toxicity and gastric anti-ulcer activity of an aqueous extract of the leaves of Macaranga barteri Müll.Arg (Euphorbiaceae) on rat models

Gastro-duodenal ulcers are diseases that constitute a major public health problem all over the world and particularly in Côte d'Ivoire. The aim of this study was to evaluate the acute toxicity and gastric anti-ulcer activity of an aqueous extract of the leaves of Macaranga barteri (AEMb). Acute toxicity was carried out using the Organization for Economic Co-operation and Development (OECD) Guidelines 420. The...

Author(s): EHILE Ehilé Hervé, GOZE Nomane Bernard, KOUAKOU Kouakou Léandre, YAPO Angoué Paul and EHILE Ehouan Etienne

February 2018

Gas chromatography–mass spectrometry (GC-MS) analysis of the constituents of the fixed oils obtained from the barks, leaves and stems of Spondias tuberosa Arruda (Anacardiaceae)

Spondias tuberosa Arruda (Anacardiaceae) is an endemic tree in the Caatinga Brazilian Biome, known locally as "umbuzeiro" and used for various purposes, especially as food and folk medicine. In this study, it was realized for the first time, the extraction and characterization by gas chromatography-mass spectrometry (GC-MS) of the fixed oils of barks, leaves and stems of S. tuberosa. The constituents of the...

Author(s): Amanda Leite Guimarães, Ana Paula de Oliveira, Geisiane Suila Feitosa dos Santos Silva, Geórgia Sueley Bezerra, Inaiara Sousa, Jackson Roberto Guedes da Silva Almeida, Joana D&#;arc de Sousa Rodrigues, José Marcos Teixeira de Alencar Filho and Edigênia Cavalcante da Cruz Araújo  

February 2018

Quantitative proteomic analysis of Isorhamnetin treatment in human liver cancer cells

Isorhamnetin (Iso) exhibits antitumor effects in promyelotic leukemia and lung cancers. However, its effect in liver cancer is not clear. This study explored the effects of Iso in human liver cancer cells and profiled the differential proteins upon Iso treatment, which contributes to a better understanding of its anticancer mechanisms. Stable isotope labeling with amino acids in cell culture-mass spectrometry:...

Author(s): Runhuan Fei and Haiyan Wei

February 2018

Antibacterial activity of Ethiopian Lepidium sativum L. against pathogenic bacteria

Lepidium sativum is commonly known as “fetto” in Ethiopia, and a popular herbal plant which is widely used in folk medicine. The objective of this study is to investigate the potential of three different crude solvent extracts from seed of Lepidium sativum (ethanol, methanol and chloroform) against human pathogenic bacterial strains: Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC-27736),...

Author(s): Yohannes Besufekad, Senbeto Beri, Tefera Adugnaw and Kibitu Beyene

February 2018

The antiulcer and antioxidant mechanisms of the butanolic fraction extract obtained from Bauhinia forficata leaves: A medicinal plant frequently used in Brazilian folk medicine

The objectives of this work were to evaluate the antiulcer activity, antioxidant mechanisms, phytochemical analysis and ecotoxicological risk of the butanolic fraction (ButFr) obtained from the leaf extracts of Bauhinia forficata. In an ischemia-reperfusion (IR), gastric ulcer model with doses 12.5 and 6.25 mg kg-1 promoted significant decreases in the ulcerative lesion area (ULA) by 50% (p<0.001) and 46%...

Author(s): Bárbara Gomes Del Rey, Luciana Lopes Guimarães, Marcos Sergio de Toledo, Hélio Kiyoshi Takahashi, Anita Hilda Straus, Monike Silva de Freitas, Bruna Hattebberger, Cláudia Maria Moraes Silva, Matheus Roberti de Carvalho and Walber Toma

February 2018

Effect of Combretum molle (Combretaceae) seed extract on hematological and biochemical parameters

Combretum molle (Combretaceae) is widely used traditional medicinal plant for treatment of different illnesses in most parts of Africa. However, its in vivo toxic effect is not evaluated yet. Thus, the aim of this study was to evaluate cytotoxic effect of C. molle seed extract on biochemical and hematological parameters using mice. Accordingly, effect of seed extract of the plant on hematological and biochemical...

Author(s): Merkin Anato, Mesele Bezabih and Tsige Ketema

January 2018

In vitro thrombolytic activity, antioxidant and cytotoxic properties of fruit extracts of Ficus erecta (Thunb.)

The aim of the study was to evaluate different biological properties of fruits extracts of Ficus erecta (Thunb.). The concentrated methanolic extracts and Kupchan partitions were screened for thrombolytic activity, whereas streptokinase was used as standard antioxidant property by evaluating free radical scavenging effect and determining total phenolic content and cytotoxic activity by brine shrimp lethality bioassay....

Author(s): Abullah Al Faysal, Yeunus Mian, Muhammed Mahfuzur Rahman, Mofiza Akter, Mahfuzur Rahman, Tariqul Haque Tuhin and Marzia Bilkiss

January 2018

Evaluation of essential oils from 22 Guatemalan medicinal plants for in vitro activity against cancer and established cell lines

Plant species which produce essential oils are important in the healthcare of rural Guatemalans. Steam distilled essential oils from 22 medicinal plant species were analyzed for activity against tongue, skin, and stomach cancer cell lines using a neutral red assay, Vero C1008 cells to assess cytotoxicity, and [3H]-thymidine incorporation assay to assess inhibition of cancer cell proliferation. IC50, CC50, and...

Author(s): Andrew Byron Miller, Rex Gordon Cates, Kim O’Neill, Juan Alfonso Fuentes Soria, Luis Vicente Espinoza, Ballantines Fabrizio Alegre, Jose Vicente Martinez and  Dany Raul Arbizu  

January 2018

Woody species from the Mozambican Miombo woodlands: A review on their ethnomedicinal uses and pharmacological potential

Miombo woodlands cover about two thirds of Mozambique national territory. They provide a wide collection of goods and services to the formal and informal economies. A review on the traditional uses of 15 Miombo tree species in human and animal health, as well as the status of research towards the identification of bioactive compounds is presented. Among the 15 species selected, 12 have been screened for their biological...

Author(s): Isabel Moura, Jossias Alberto Duvane, Maria José Silva, Natasha Ribeiro and Ana Isabel  Ribeiro-Barros

January 2018

Ethnobotanical study of medicinal plants used to manage HIV/AIDS opportunistic infections in Rungwe, Mbeya Region, Tanzania

The current ethnobotanical study identified medicinal plant species used to manage HIV/AIDS opportunistic infections by the communities in Rungwe District, Tanzania. Data were collected using questionnaires (n=193), interviews (n=9) and field observations. A total of 31 plant species from 23 families are used in managing HIV/AIDS opportunistic infections. Compositae and Rosaceae were predominantly used in disease...

Author(s): Suma F. Kibonde, Suzana Augustino, Faith P. Mabiki and Robinson Mdegela

January 2018

Therapeutic and pharmaceutical benefits of native and modified plant pectin

Plant pectin constitutes an important class of naturally occurring polysaccharides and are widely distributed in various fruits and vegetables consumed on a regular basis. These biomolecules are reported to exhibit a vast array of biological activities including effects on digestive system, chemo-preventive effect in colon cancer, regulation of blood cholesterol level and immune-potentiating effects. However, variation...

Author(s): Sutapa Biswas Majee, Dhruti Avlani, Priyanka Ghosh and Gopa Roy Biswas

January 2018

A novel anti-triple negative breast cancer compound isolated from medicinal herb Myrothamnus flabellifolius

Triple negative breast cancer (TNBC) is a disease that impacts millions of people around the world. There is an urgent need to find new therapies, specific to triple negative cancer cells with minimal effect on normal cells. This study explores the use of Myrothamnus flabellifolius as an anti-TNBC. Using High Performance Liquid Chromatography, the extract was fractionated and each fraction was tested against TNBC cells...

Author(s): Jaspal Brar, Norman Fultang, Kayla Askey, Maria Cristina Tettamanzi and Bela Peethambaran

December 2017

Preference analysis between the use of drugs and plants in pain management in a quilombola community of the state of Ceará, Brazil

The objective of this study was to analyze the context of the management of people from traditional quilombola community, in relation to the use of plant species and allopathic drugs used in treatment of pain. Questionnaires were used to determine the socio-demographic profile and the interview-semi-structured method with participants adopted. The analysis of data was done by statistics for the socio-demographic...

Author(s): Ádamo Xenofonte Brasil, Maysa de Oliveira Barbosa, Izabel Cristina Santiago Lemos, Cícera Norma Fernandes Lima, Gyllyandeson de Araujo Delmondes, Giovana Mendes de Lacerda, Álefe Brito Monteiro, Diógenes de Queiroz Dias, Andressa de Alencar Silva, George Pimentel Fernandes, Roseli Barbosa, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf

December 2017

Physicochemical properties and antimicrobial activities of soap formulations containing Senna alata and Eugenia uniflora leaf preparations

Senna alata leaf extract demonstrates antimicrobial properties that promise utility for treatment of topical infections. Its combination with similarly bioactive Eugenia uniflora leaf extract in soap formulation could enhance anti-infective efficacy. The objective of this study was to develop potent antiseptic herbal soap formulations (HSFs) with the combined leaf extracts of the two plants. A soap base having suitable...

Author(s): Ayobami O. Oyedele, Ezekiel O. Akinkunmi, Doyinsola D. Fabiyi and Lara O. Orafidiya

December 2017

Aqueous extract of Persea americana leaves ameliorates alloxan-induced hyperglycaemia and hyperlipidaemia in rats

Decoctions of Persea americana Mill (Lauraceae) leaves are employed to manage diabetes mellitus among the Ibo communities of Eastern Nigeria. In this study, we studied the ameliorative effects of the aqueous extract of P. americana leaves (AEPAL) on alloxan-induced hyperglycaemia and hyperlipidaemia in Wistar rats. The oral median lethal dose (LD50) of AEPAL was determined in rats. The effects of extract on blood...

Author(s): Stephen Chiadikaobi Okafor, Steven Samuel Gyang, Bilkisu Bello Maiha, Ejike Daniel Eze, Musa Itopa Yakubu and Ben Ahmed Chindo,

December 2017

Phytochemical screening and In Vivo antimalarial activities of crude extracts of Lantana trifolia root and Premna oligotricha leaves in plasmodium berghei infected mice

Resistance of malaria parasites to several antimalarial drugs mandates the need for new compounds from affordable sources. Thus the current study was conducted to justify the  traditional usage of Lantana trifolia roots and Premna oligotricha  leaves to combat malaria. The powdered roots of Lantana trifolia and leaves of Premna oligotricha  were macerated using 70% ethanol. Secondary metabolites present...

Author(s): Sisay Seyfe, Alemayehu Toma, Atkilt Esaiyas, Etana Debela,  Abraham Fikru and Amelework Eyado

December 2017

Medicinal value of Aptosimum albomarginatum (Marloth and Engl.), Albizia anthelmintica (A. Rich Brongn.) and Dicoma schinzii (O. Hoffm.) to a small community living at Gochas, southern Namibia

Traditional medicine is widely used, but its effectiveness is often questioned. Biofilm-producing bacteria and fungi are important in difficult-to-treat persistent and recurrent infections. The present study investigated the anti-biofilm properties of crude methanolic extracts from three medicinal plants used in Namibia, namely Aptosimum albomarginatum (Marloth and Engl.), Albizia anthelmintica (A. Rich Brongn.) and...

Author(s): Sunette Walter, Mervyn Beukes, Davis Mumbengegwi and Ronnie Böck

December 2017

Development of emulsion containing watermelon extract for skin aging

Watermelon [Citrullus lanatus (Thunb) Matsum and Nakai] is rich in vitamins C and B complex, and the red color of its pulp is due to the presence of lycopene. Lycopene is an antioxidant component and it is able to neutralize free radicals especially responsible for skin aging. Thus, a formulation containing lycopene extracted from watermelon was developed, and its physical-chemical stability and in vitro antioxidant...

Author(s): Letícia Caramori Cefali, Janaína Artem Ataide, Roseane Teresa Donegá, Karolina de Melo Silva Godoy, Fernanda Gomes de Araújo and Priscila Gava Mazzola

December 2017

Phenolic profile and antioxidant capacity of Cnidoscolus chayamansa and Cnidoscolus aconitifolius: A review

Research into ancient cultures has yielded a large body of evidence on the use of medicinal plants for preventive and/or therapeutic purposes. Such plants may have many metabolic activities and functions in the body-antioxidant, anti-inflammatory, platelet aggregation inhibitory and immunological and they can act at different molecular levels. This work offers a comprehensive review of research into the phenolic profile...

Author(s): A. Kuri-García, J. L. Chávez-Servín and S. H. Guzmán-Maldonado

December 2017

Bioactivity of bizzy nut extract in prostate cancer cells

Cola acuminate is one of the three edible forms of bizzy nut that has been used for medicinal and therapeutic purposes. However, the precise compound responsible for its biological effects has not been completely identified. Using sequential solid--liquid extraction of bizzy nut coupled with bioactive screening, ether extract was obtained (Biz-2) and it possesses tumor inhibitory activity specific for prostate cancer...

Author(s): Orville Phillip, Caroline Telles and Wesley Gray

November 2017

Valeriana officinalis and melatonin: Evaluation of the effects in Drosophila melanogaster rapid iterative negative geotaxis (RING) test

The rapid iterative negative geotaxis (RING) assay is a commonly used behavioral test in Drosophila based on digital imaging of flies and requires minimal equipment and space. Larval mobility can be used to reliably determine the effect of drugs on locomotion in Drosophila larvae. The effects of Valeriana officinalis extract (VoE) and melatonin (ME) were tested in Drosophila melanogaster flies and larvae. In the RING...

Author(s): Dilliane Crisley Cheuczuk, Suelen Freitas, Jaqueline Vaz and Welligton Luciano Braguini

November 2017

Effects of Tinospora crispa aqueous extract in regulating cholesterol metabolism in human hepatoma cancer cell line (Hep G2)

In this study, the ability of Tinospora crispa aqueous extract (TCAE) to regulate cholesterol metabolism in human hepatoma cancer cell line (Hep G2) was determined. Cytotoxic study was performed by exposing hepatoma cell (Hep G2) towards TCAE with concentration ranging from 0.002 to 20 mg/ml for 24 h at 37°C and with 5% CO2 atmosphere. Result revealed that TCAE was not toxic to the cell. The ability of TCAE to...

Author(s): Zamree Md Shah, Mohd Kamal Nik Hasan, Shahidan Mohd Arshad, Khairul Kamilah Abdul Kadir, Ihsan Safwan Kamarazaman, Zulkhairi Amom, Rasadah Mat Ali and Daryl Jesus Arapoc

November 2017

Antimicrobial evaluation of endophytic fungi extracts isolated from Casearia sylvestris

Due to widespread bacterial resistance to commercial antibiotics, the search for capable substances to combating these microorganisms became a priority. In this context, the endophytic fungi gained prominence as potential producers of bioactive substances with pharmacological interest. It is considering that endophytes are still poorly studied, especially in tropical species. The antibacterial and antifungal potential...

Author(s): Ernane Gerre Pereira Bastos, Aline Aires Aguiar, Adriana Idalina Torcato de Oliveira,  Juliana Fonseca Moreira da Silva and Raphael Sanzio Pimenta

November 2017

Effect of Ephedra foeminea active compounds on cell viability and actin structures in cancer cell lines

Ephedra is likely one of the oldest medicinal plants still currently in use. In folk medicine, extracts of Ephedra foeminea are commonly used to treat cancer patients. In relation to its traditional use, the aim of the present study was to determine the cytotoxic activity in vitro of E. foeminea extracts on cancer and non-cancer cells. Cell viability was determined using XTT assay, induction of apoptosis by cell sorting...

Author(s): Maayan Mendelovich, Monick Shoshan, Marcelo Fridlender, Moran Mazuz, Dvora Namder, Rameshprabu Nallathambi, Gopinath Selvaraj, Puja Kumari, Aurel Ion, Smadar Wininger, Ahmad Nasser, Mohamed Samara, Yaacov Sharvit, Yoram Kapulnik, Native Dudai and Hinanit Koltai

November 2017

Phytochemical composition, acute toxicity and phytohormonal activity of hydroalcoholic extract of Pentadesma butyracea (Clusiaceae Sabine (1824)) seeds

Pentadesma butyracea is a rainforest species of Clusiaceae family with multi-values for human healthcare according to previous ethnobotanical survey. In spite of this traditional use of P. butyracea, there is a lack of scientific knowledge of its biological activities. Therefore, the aim of this study was to identify the major phytochemical compounds of P. butyracea hydroalcoholic seeds extract and to assess...

Author(s): TINDANO Basile, BAYALA Balé, DOUKOURE Maya, BELEMTOUGRI G. Raymond, TAMBOURA H. Hamidou and SAWADOGO Laya

November 2017

Anti-proliferative and cytotoxic effects of methanol extract of the leaves of Momordica charantia L. (Cucurbitaceae) on vascular smooth muscle cells (VSMC) and HT-29 cell lines

Momordica charantia has been used traditionally for the treatment of several ailments. Some natural plant products are known to exhibit cytotoxic or anti-proliferative effects on cancer cell lines, such plants offer a promising therapeutic approach as an anti-tumor agent. In this study, the anti-proliferative effects of graded concentrations of methanol leaf extract of M. charantia (MEMC) at different point time was...

Author(s): Ofuegbe S. O., Oyagbemi A. A., Omobowale T. O., Fagbohun O. S., Yakubu M. A. and Adedapo A. A.

November 2017

Effect of auxin and cytokinin on phenolic content of Baccharis myriocephala DC. (Asteraceae) produced in vitro

A protocol for large-scale in vitro production of Baccharis myriocephala was developed. Total phenolic content was analyzed in plants cultured on MS + 1.0 mg.L-1 of indoleacetic acid (IAA), benzyladenine (BA) or kinetin (KIN). Nodal segments obtained from seeds germinated in vitro on Murashige and Skoog basal medium (MS) were subcultured on MS basal medium, hormone-free or with different growth regulators added: IAA, BA...

Author(s): Sharon Santos de Lima⊃, Simone da Silva⊃, Claudio Barbosa Moreira⊃, Celso Luiz Salgueiro Lage and Alice Sato

November 2017

Development of a rich fraction in phenolic compounds with high antioxidant and antimicrobial activity in Amburana cearensis seeds extracts

Amburana cearensis is a medicinal plant widely used in folk medicine. The purpose of this study was to identify the more appropriate extraction solvent for maximum antioxidant and antimicrobial effect. The extraction of A. cearensis seeds were carried out gradually to obtain the highest yields and constituents of the extracts using as solvent hexane, methanol, 80% alcohol and water in this sequence. Phytochemical...

Author(s): Aline Aires Aguiar, Ilsamar Mendes Soares, Poliana Guerino Marson, Ernane Gerre Pereira Bastos, Sérgio Donizeti Ascêncio and Raimundo Wagner de Souza Aguiar

October 2017

Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents

The Vietnam-Laos International Cooperative Biodiversity Group (ICBG) based at the University of Illinois at Chicago (UIC) catalyzed a country-wide network of medicinal plant preserves (MPP) and medicinal biodiversity preserves (MBP) now established in ten provinces of the Lao People’s Democratic Republic (Lao PDR), which are relied upon as protected sources of ethnomedicines for local villagers and traditional...

Author(s): Joshua M. Henkin, Kongmany Sydara, Mouachanh Xayvue, Onevilay Souliya, A. Douglas Kinghorn, Joanna E. Burdette, Wei-Lun Chen, Bethany G. Elkington and Djaja D. Soejarto

October 2017

In vitro antimicrobial activity and fatty acid composition through gas chromatography-mass spectrometry (GC-MS) of ethanol extracts of Mauritia flexuosa (Buriti) fruits

In this study, the chemical composition of the peel and pulp of Mauritia flexuosa fruits were analyzed and the antimicrobial activity of ethanolic extracts from these fruits was evaluated using in vitro tests. Chemical composition analysis with gas chromatography-mass spectrometry (GC-MS) indicated the presence of saturated and unsaturated fatty acids. The peel extracts (ECBU) presented 54.41% and the pulp (EPBU)...

Author(s): Adriana Idalina Torcato de OLIVEIRA, Jhonatha Barros CABRAL, Talal Suleiman MAHMOUD, Guilherme Nobre L. do NASCIMENTO, Juliana Fonseca Moreira da SILVA, Raphael Sanzio PIMENTA and Paula Benevides de MORAIS

October 2017

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

The aim of this study was to evaluate the chemical composition and antimicrobial activity of four unexplored Eugenia species: Eugenia brevistyla, Eugenia handroana, Eugenia catharinae and Eugenia stigmatosa. Eight extracts and eighteen fractions were screened for their antibacterial activity against some selected bacteria including Mycoplasma. Phytochemical screening revealed that the plants were rich in terpenes and...

Author(s): Adrielli Tenfen, Ariela M. Boeder, Catarina C. Bella-Cruz, Alexandre Bella-Cruz, Caio M. M. Córdova and Valdir Cechinel-Filho

October 2017

Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

Eugenia uniflora L. (Myrtaceae) is popularly known in Brazil as pitanga or ibitanga. The infusion of E. uniflora leaves is being used in folk medicine as anti-diarrheal. The present study sought to evaluate the gastroprotective potential of the aqueous fraction of hydroacetonic leaf extract of pitanga (AFHP). The leaf powder of pitanga was extracted with 50% acetone using an overhead stirrer apparatus at room...

Author(s): José Luís Rodrigues M., Dayane Moreira da S., James Oluwagbamigbe F., Emerith Mayra Hungria P., Eric de Souza G., Anderson Luiz F., Suzana da Costa S. and Elson Alves C.

October 2017

Immunoregulatory activity of root bark of Cassia sieberiana D.C. in a modified adjuvant-induced arthritis in rat

The present study seeks to evaluate the immunoregulatory effects of extracts of the root bark of Cassia sieberiana, a plant used in Ghana for various painful inflammatory conditions, in a modified adjuvant arthritis model induced by administration of very low dose of Mycobacterium tuberculosis (MT) – carrageenan mixture in the rat. A volume of 0.1 mg kg-1 heat killed MT in paraffin oil was mixed with equal volume...

Author(s): Kofi Donkor, Eric Woode and Laud Kenneth Okine

October 2017

Methoxy-flavones identified from Ageratum conyzoides induce capase -3 and -7 activations in Jurkat cells

New therapies for leukemia are urgently needed due to adverse side effects, tumor resistance and lack of selectivity of many chemotherapeutic agents in clinical use. Ageratum conyzoides has been used in folklore medicine for managing leukemia and other cancers. Thus, this study aimed to investigate the effects of fractions, sub-fractions and purified compounds from the ethanol leaf extracts of A. conyzoides against...

Author(s): Felix Acheampong, John Reilly, Christopher Larbie, Matthew Spencer, Karl Gunderson, Regina Appiah-Opong Christopher Howson, Jennifer Porier, Kellie Joyce, Valentina Jeliazkova, Sarah Voytek, Carol Ginsburg-Moraff, Stefan Thibodeaux, Jill Kublbeck and Steven Austin

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