Metabolite profiling of different solvent extracts of Moringa oleifera seeds and correlation with DPPH radical scavenging activity via 1H NMR-based metabolomics
September 2023
In the present study, profiling of the Moringa oleifera seeds metabolome was carried out by employing proton nuclear magnetic resonance (1H NMR) spectroscopy combined with multivariate data analysis (MVDA) of 3 different solvent extracts. The principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA) score plot reveal that methanol extract was discriminated from ethyl acetate and hexane...
Taurine is a future biomolecule for potential health benefits: A review
September 2022
Taurine is a sulfur-containing amino acid that is converted to a neutral beta-amino acid, chemically known as (2-Amino-ethane sulfonic acid) having chemical formula C2H7NO3S. It was first isolated from Ox bile, and thus derives its name from the Latin word “Taurus”, meaning 'ox' or 'bull'. This is the only amino acid that is extensively found in animal tissue. The richest source of taurine is...
1H NMR urine metabolomics is an effective prognostic indicator in acute spinal cord injury (ASCI): A prospective case-control study
October 2020
Acute spinal cord injury (ASCI) is an extremely overwhelming disease with high morbidity and mortality. Despite significant successes in understanding the pathophysiology of ASCI, little is known about limiting neurological damage and predicting recovery. Biofluid metabolomics by 1H NMR spectroscopy for metabolites quantification specific to nervous tissue injury may determine the injury and progression. This study...
Virtual environments for mental health issues: A review
April 2014
Three-dimensional (3D) environments are increasingly being used to provide therapy to those suffering from mental health problems. Virtual environments can provide a safe and realistic simulation to expose patients to the cause of their problem. This paper presents a review of the use of 3D environments to assess and treat mental health problems. Within the review applications to treat mental health problems such as...
Conception of biological networks at the molecular level as orchestrated systems of oscillators representing interconnected modular molecular clocks
September 2011
Biological networks are extremely complex objects. Still representation of them remains to be very simple. Here hypothesis representing all regulatory cellular processes as cycles connected to each other is provided. Cycles were introduced as minimal parts of network containing negative feedback loop. All cycles were interconnected between each other by common members of network; it can be gene, protein or metabolite....
Metabolite profiling of endophytic fungal isolates of five ethno-pharmacologically important plants of Meghalaya, India
September 2011
Crude metabolite extracts derived from the culture broths of endophytic fungi of five ethno-pharmacologically important plant species used by the ethnic tribes of the hill state of Meghalaya in North-East India were screened for the presence of toxins and secondary metabolites using agar plug paper chromatography, TLC (thin layer chromatography) and LC-MS (liquid chromatography-mass spectroscopy). The endophytic fungal...
Urinary metabolic profiling in rats due to heat exposure using 1H high resolution NMR spectroscopy
April 2011
Acute heat stress may trigger systemic biochemical and physiological changes in living organisms leading to rapid loss of homeostasis. Metabolic regulatory process during heat stress has been poorly understood therefore the present study was undertaken in order to have an insight of alterations in various metabolites due to acute heat stress exposure using nuclear magnetic resonance (NMR) spectroscopy. Male...
Determination and detoxification of cyanide content in sorghum for ethanol production using Saccharomyces cerevisiae strain
April 2011
Sorghum is a promising crop for the animal feed and fuel ethanol production. Presence of cyanide in its biomass, particularly in the tips of young leaves, carries some risk of toxicity to livestock and microbes, especially when at an immature stage of growth, its application may be restricted. The study was carried out at Indian Agricultural Research Institute, New Delhi with nine forage sorghum cultivars to determine...
Prevalence of (high-pathogenicity island) HPI-harboring Escherichia coli in diarrheic and healthy piglets
August 2010
One hundred and sixty four rectal swab samples were collected from 110 live diarrheic piglets and 54 healthy piglets during an investigation on the prevalence of HPI-harboring Escherichia coli (HPI + E. coli) infection associated with porcine diarrhea. The data of polymerase chain reaction (PCR) revealed the presence of HPI + E. coli in 58.18% of swabs taken from...
Effect of dehydration on the nutritive value of drumstick leaves
August 2010
Food based strategy’ is used as a tool for combating micronutrient deficiencies. It is also referred as dietary modification, which encompasses a wide variety of intervention that aim at increasing the production, availability and consumption of food products, which are rich in micronutrients. One such food products are green leafy vegetables. There are many varieties of green leafy vegetables which...
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