HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors: Evaluation of the role and actions in age-related macular degeneration
August 2010
Age-related macular degeneration (ARM) is a progressive late onset disease affecting central vision. It is the leading cause of irreversible blindness among older adults in developed countries, and with the aging population, the problem is increasing. Current treatment options by endothelial growth factor (VEGF) inhibitors – anti-VEGF therapy are limited to the late stage of the disease, when central...
Effect of Ipomoea batatas leaf extract on the thyroid-gonadal axis of male Wistar rats
August 2010
The effect of the leaf extract Ipomoea batatas was investigated on the thyroid gonadal axis of male rats. The leaf extract of I. batatas was extracted by dissolving a measured dry-powder leaf sample in a known volume of distilled water. The soaked plant sample was allowed to stand overnight for 24 h. The sample was filtered and the filtrate evaporated into solid extract. Three doses of the...
The impact of viva-voce examination on students’ performance in theory component of the final summative examination in physiology
April 2010
Viva voce examinations formed a part of theory component of final summative examination. Since viva voce was conducted to all students irrespective of their passing status in theory, the exercise was found to be time consuming. In this perspective, this study was conducted to determine the impact of viva voce examination on student performance in the summative examination. Three batches of first year medical...
Anti-plasmodial and toxicological effects of methanolic bark extract of Chrysophyllum albidum in albino mice
April 2010
The anti-plasmodial, hematological, serum biochemical and pathological effects ofChrysophyllum albidum methanolic bark extract were evaluated using Swiss albino male mice as models. The plant is used in Southern Nigeria as a remedy for malaria and yellow fever. The LD50 of the methanolic extract was 1850 mg/kg body weight. C. albidum methanolic bark extract (750 - 1500 mg/kg/day) exhibited...
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