African Journal of Biotechnology
Subscribe to AJB
Full Name*
Email Address*

Article Number - 77B65A57935


Vol.8(7), pp. 1183-1187 , April 2009
DOI: 10.5897/AJB2009.000-9188
ISSN: 1684-5315



Full Length Research Paper

Trino IB ameliorates the oxidative stress of cryptorchidism in the rat


A.O. Afolabi1*, O. Aluko1, O. Oyewopo2, B.M. Olabinri3, O. Olotu1 and Y. Raji4




 

1Physiology Department, College of Health Sciences, LAUTECH, Ogbomoso, Nigeria.

2Anatomy Department, College of Health Sciences, LAUTECH, Ogbomoso, Nigeria.

3Biochemistry Department, College of Health Sciences, LAUTECH, Ogbomoso, Nigeria.

4Physiology Department, College of Medicine, UNIBADAN, Ibadan, Nigeria.


Email: oasafolabi@yahoo.com






 Accepted: 05 December 2008  Published: 06 April 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

The study examined the effect of Trino IB, a mixture of oleuropein and α-lipoic acid, on the plasma concentration of g-glutamyl transpeptidase (GGT), malondialdehyde (MDA), sperm count and apoptotic degeneration of testicular germ cells in experimentally induced cryptorchidism in adult male rats. Oral administration of Trino IB (0.5 ml/kg body weight) for 56 days to rats caused significant reduction (P<0.05) in the plasma concentration of GGT in the treated groups, but no significant difference (P=0.0839) in the plasma MDA concentration was observed. Histologically, Trino IB administration significantly elevated (P<0.05) the number of sperm cells in the treated cryptorchid groups compared to the untreated cryptorchid groups. Trino IB alleviated apoptotic degeneration of germ cell in the testes of the treated groups, while there was apoptotic degeneration in the testicular germ cells of the untreated groups. Trino IB alleviated the deleterious effect of oxidative stress in induced cryptorchidism.

 

Key words: Cryptorchid, oxidative stress, Trino IB, g-glutamyl transpeptidase, malondialdehyde.


APA Afolabi, A. O., Aluko, O., Oyewopo, O., Olabinri, B. M., Olotu, O., & Raji, Y. (2009). Trino IB ameliorates the oxidative stress of cryptorchidism in the rat. African Journal of Biotechnology , 8(7), 1183-1187.
Chicago A.O. Afolabi, O. Aluko, O. Oyewopo, B.M. Olabinri, O. Olotu and Y. Raji. "Trino IB ameliorates the oxidative stress of cryptorchidism in the rat." African Journal of Biotechnology 8, no. 7 (2009): 1183-1187.
MLA A.O. Afolabi, et al. "Trino IB ameliorates the oxidative stress of cryptorchidism in the rat." African Journal of Biotechnology 8.7 (2009): 1183-1187.
   
DOI 10.5897/AJB2009.000-9188
URL http://academicjournals.org/journal/AJB/article-abstract/77B65A57935

Subscription Form