African Journal of Biochemistry Research
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Article Number - 1C4D19C11705


Vol.7(9), pp. 179-183 , October 2013

ISSN: 1996-0778



Full Length Research Paper

The effects of Yucca schidigera on blood glucose and lipid levels in diabetic rats


 

Nuray OZTASAN




 

Department of Physiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.


Email: nurayoztasan@hotmail.com






 Accepted: 19 March 2013  Published: 31 October 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

The aim of this study was to investigate the effects of Yucca schidigera (YSE) on lipid peroxidation and some biochemical parameters in streptozotocin-induced (STZ) diabetic rats. Four groups of seven rats each were used in this study. Supplementation period was three weeks. The groups were: I. control group (C), normal feed; II. diabetic (DM-YSE), normal feed plus YSE 100 ppm/kg; III. diabetic (DM), normal feed; and IV. yucca group (YSE), normal feed plus YSE 100 ppm/kg. malondialdehyde, glutathione, cholesterol, triglyceride and glucose levels were measured by spectrophotometric methods whereas insulin and leptin levels were measured by ELISA. Pancreatic tissues were examined to distinguish histopathological changes. YSE had increased plasma insulin levels in yucca group compared to the diabetics. There was no significant difference in leptin levels between control and diabetic groups while a significant increase was observed in YSE fed groups compared to others. There was no significant difference among four groups in terms of triglyceride or cholesterol levels. No histological anomalies were observed in pancreatic tissues when compared to the control group, however, STZ-DM induced changes were detected. According to the results of the study, YSE does not have a direct effect on glucose levels in diabetics, however it may act through insulin.

 

Key words: Diabetes Mellitus, Oxidative stress, Yucca schidigera, Histopathological changes.

Al-Achi A (2005). Herbs that affect blood levels. Women's Health in Primary Care 8: 325- 330.
 
Altan N, Dincel AS, Koca C (2006). Diabetes Mellitus and Oxidative Stress. Turk J. Biochem. 31: 51-56.
 
Andrews JF (1998). Leptin: energy regulation and beyond to a hormone with pan-physiological function. Proc. Nutr. Soc. 57: 409-411.
 
Bhor VM, Raghuram N, Sivakami S (2004). Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats. Int. J. Biochem. Cell Biol. 36(1): 89-97.
 
Bingham R, Haris DH, Laga T (1978). Yucca plant saponin in the treatment of hypertension and hypercholesterolemia. J. Appl. Nutr. 30: 127-136.
 
Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA (1997). Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes 46: 1235-1238.
 
Cariello A (2000). Oxidative stress and glycemic regulation. Meta-bolism 49: 27-29.
 
Cariello A (2003). New insights on oxidative stress and diabetic complications may lead to a "Casual" antioxidant therapy. Diabe-tes Care 26: 1589-1596.
 
Casanueva FF, Diaguez C (1999). Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol. 20: 317-363.
 
Cefalu WT (2002). Insulin resistance: Cellular and Clinical Concepts. Exp. Biol. Med (Maywood). 226(1):13-26.
 
Chakrabarti R, Rajagopalan R (2002). Diabetes and insulin resis-tance associated disorders: Disease and the therapy. Curr. Sci. 83: 1533-1538.
 
Cheeke PR (1999). Actual and potential applications of Yucca Schidigera and Quillaja Saponaria saponin. Proc. A. Soc. Anim. Sci., 1: 1-10.
 
Cheeke PR, Piacente S, Oleszek W (2006). Anti-inflammatory and anti-arthritic effects of Yucca Schidigera: A review. J. Inflam 3: 1-7.
 
Dandona P, Thuru K, Cook S, Snyder B, Makowski J, Armstrong D, Nicotera T (1996). Oxidative damage to DNA in Diabetes Mellitus. Lancet 347: 444-445.
 
Dincer Y, Akcay T, Ilkova T, Alademir Z, Ozbay G (2003). DNA damage and antioxidant defense in peripheral leukocytes of patients with type I Diabetes Mellitus. Mutat. Res. 527: 49-55.
 
Draper HH, Hardley M (1990). Malondialdehyde determination as index of lipid peroxidation. Meth. Enzymol. 186: 421-431.
 
Duffy CF, Killeen GF, Connolly CD, Power RF (2001). Effects of dietary supplementation with Yucca Schidigera Roezl ex Ortgies and its saponin and nonsaponin fractions on rat metabolism. J. Agric. Food Chem. 49: 3408-3413.
 
Eddouks M, Maghrani M, Michel JB (2005). Hypoglycaemic effects of Triticum repens P. Beauv in normal and diabetic rats. J. Ethnopharm. 102: 228-232.
 
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Reports of the Expert Committee on the Diagnosis and Classification of Diabetes (2003). Diabetes Care 26 (Suppl 1): 5-20.
 
Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM (1997). Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. USA 94 (13): 7001-7005.
 
Francis G, Kerem Z, Makkar HPS, Becker K (2002). The biological action of saponins in animal system: a review. Br. J. Nutr. 88: 587-605.
 
Giugliano D, Ceriello A, Paolisso G (1996). Oxidative stress and diabetic vascular complications. Diabetes Care 19 (3): 257-267.
 
Green A, Christian Hirsch N, Pramming SK (2003). The changing World Demohraphy of type 2 diabetes. Diabetes Metab. Res. Rev. 19: 3-7.
 
Guclu KB, Iscan KM, Uyanık F, Eren M, Agca AC (2004). Effects of alfa meal added to diet of laying quail on performance egg quality and some serum parameters. Arch. Anim. Nutr. 58: 225-263.
 
Gurbilek M, Daglar C, Akoz M, Topcu C (2004). The effect of dis-ease duration on erythrocyte membrane Na-K/ATP ase enzyme activity, lipid peroxidation, and DHEA(S), glucose and lipid levels in the Diabetes Mellitus patients. Turk J. Biochem. 29: 237-242.
 
Harris M, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR (1998). Prevalance of diabetes, impaired fasting glucose and impaired glucose tolerance in U.S. adults. The Third National and Nutrition Examination Survey. Diabetes Care 21: 518-526.
 
Houseknecht KL, Baile CA, Matteri RL, Spurlock ME (1998). The biology of leptin: a review. J. Anim. Sci. 76: 1405-1420.
 
Lee GH, Proenca JM, Montez KM, Carrol JG, Darvishzadeh JI, Friedman JM (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 (6566): 632-635.
 
Lee KT, Sohn IC, Kim DH, Choi JW, Kwon SH, Park HJ (2000). Hypoglycemic and hypolipidemic effects of Tectorigenin and Kaikosaponin-III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro. Arch. Pharm. Res. 23: 461-466.
 
Li WL, Zheng HC, Bukuru J (2004). Natural Medicines used in the traditional Chinese medical system for therapy of Diabetes Mellitus. Ethnopharmacology 92: 1-21.
 
Malinow MR, Connor WE, Mc Laughlin P (1981). Cholesterol and bile acid balance in Macaca fascicularis effect of alfa saponins. J. Clin. Invest. 67 (1): 156-162.
 
Pessin JE, Saltiel AR (2000). Signaling pathways in insulin action: molecular targets of insulin resistance. J. Clin. Invest. 106: 165-169.
 
Price KR, Johnson IT, Fenwick GR (1987). The chemistry and biological significance of saponins in foods and feed stuffs. Crit. Rev. Food. Sci. Nutr. 26(1):27-135.
 
Rao D, Kendall CW (1986). Dietary saponins and serum lipids. Fd. Chem. Toxic. 24: 441.
 
Sidhu GS, Oakenfull DG (1986). A mechanism for the hypo-cholesterolaemic activity of saponins. Br. J. Nutr. 55: 643-649.
 
Southon S, Johnson IT, Gee JM, Price KR (1988). The effect of gypsophila saponins in the diet on mineral status and plasma cholesterol concentration in the rat. Br. J. Nutr. 59: 49-55.
 
Sparg SG, Light ME, Van Staden J (2004). Biological activities and distribution of plant saponins. Ethnopharmacology 94: 219-243.
 
Sur P, Chaudhuri T, Vedasiromoni JR, Gomes A, Ganguly DK (2001). Antiinflammatory and antioxidant property of saponins tea. Biol. Pharm. Bull. 24: 209-213.
 
Wever R, Luscher T, Consentina F (1998). Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 97: 108-112.

 


APA (2013). The effects of Yucca schidigera on blood glucose and lipid levels in diabetic rats. African Journal of Biochemistry Research , 7(9), 179-183.
Chicago   Nuray OZTASAN. "The effects of Yucca schidigera on blood glucose and lipid levels in diabetic rats." African Journal of Biochemistry Research 7, no. 9 (2013): 179-183.
MLA   Nuray OZTASAN. "The effects of Yucca schidigera on blood glucose and lipid levels in diabetic rats." African Journal of Biochemistry Research 7.9 (2013): 179-183.
   
DOI
URL http://academicjournals.org/journal/AJBR/article-abstract/1C4D19C11705

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