African Journal of Biochemistry Research
Subscribe to AJBR
Full Name*
Email Address*

Article Number - 84709A965044


Vol.11(6), pp. 28-33 , June 2017
DOI: 10.5897/AJBR2017.0930
ISSN: 1996-0778



Full Length Research Paper

Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats



Adegbite A. Victor
  • Adegbite A. Victor
  • Department of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar
Ezekwesili C. Nonyelum
  • Ezekwesili C. Nonyelum
  • Department of Anatomic Pathology, Anambra State University, Awka, Anambra State, Nigeria.
  • Google Scholar







 Received: 16 January 2017  Accepted: 26 May 2017  Published: 30 June 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


One of the commonly consumed leafy vegetables in Nigeria is Pterocarpus mildbraedii Harms (Leguminosae) leaf. It has been found that, ethanol and aqueous extracts of the plant leaves exert anti-diabetic effect on rats. This study investigated the effects of ethanol and aqueous leaf extracts of this plant on some hematological parameters and serum cholesterol level in Wistar albino rats. Intraperitoneal administration of ethanol and aqueous extracts of P. mildbraedii leaves at the doses of 200 and 400 mg kg-1, on two groups of rats for 28 days showed no adverse effects on the hematological parameters considered in this study. There was a significant (p < 0.05) dose dependent increase in almost all the hematological parameters. However, the serum cholesterol level was significantly reduced in rats exposed to both doses of the ethanol and aqueous extracts of the plant leaf as compared to the rats in the control group. These effects of the extracts increased with increased doses. These results suggest non-toxic effects of the leaf extracts of P. mildbraedii on the hematological parameters, as well as an ability to help in preventing cardiovascular diseases in the diabetics.

 

Key words: Pterocarpus mildbraedii, hematology, cholesterol, heart, packed cell volume, hemoglobin, toxicology.

Adegbite AV, Ezekwesili CN, Okani OC (2015). Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on the liver function and CD4 cells of the immune system in albino rat. Bioscientist 3(1):79-87.

 

Adeneye AA, Ajagbonna OP, Adeleke TI, Bello SO (2006). Preliminary toxicity and phytochemical studies of the stem bark aqueous extract of Musanga cecropioides in rats. J Ethnopharmacol. 105:374-379.
Crossref

 
 

Akpayung IO, Udoh AP, Akpan EJ (1995). Chemical composition of the edible leaves of Pterocarpus mildbraedii, Plant Foods Human Nutr. (Netherlands) 48:2O9-215.

 
 

Asante-Duah K (2002). Public Health Risk Assessment for Human Exposure to Chemicals (illustrated.); Kluwer Academic Publishers: Dordrecht, The Netherlands. pp. 234-258.

 
 

Ayman MM (2013). Hematological alterations in diabetic rats-role of adipocytokines and effects of citrus flavonoids. Exper. Clin. Sci. J. 12:647-657.

 
 

Eunjin K, Chulwoo A (2012). Low Hemoglobin Concentration is Associated with several Diabetic Profiles. Korean J. Intern. Med. 27:273-274.
Crossref

 
 

Eyo ES, Abel U (1983). Chemical composition and amino acid content of Gnetum africanum. Nig. J. Nutr. Sci. 4:57-62.

 
 

Ezekwesili CN, Adegbite AV, Okani OC (2016). Effects of Aqueous and Ethanolic extracts of Pterocarpus mildbraedii on renal and heart functions of albino rats. Anim. Res. Int. 13(2):2446-2453.

 
 

Gayatri N, Mruntyanjay S, Rahani KS (2014). Antioxidant Potential and Nutritional Values of Vegetables: A Review. Res. J. Med Plants 8:50-81.
Crossref

 
 

Goh EC, Jeong YY, Donghee K, Min-Sun K, Jong IY, Su J C, Sun YY, Joo SK (2016). Association between White Blood Cell Coount and the Development of Incidental Nonalcoholic Fatty Liver Disease. Gastroenterol. Res. Pract. 4:1-6.

 
 

Jennifer SJ, Elizabeth DN, Elvin A (2012). Factors related to fruit, vegetable and traditional food consumption which may affect health among Alaska Native People in Western Alaska. Int. J. Circumpolar Health 71:17345.
Crossref

 
 

Kulkarni YA, Veeranjaneyulu A (2012). Toxicological Evaluation of the Methanol Extract of Gmelina arborea Roxb.Bark in Mice and Rats. Toxicol. Int. 19:2.

 
 

Marco M, Carmen M, Ferdinando M, Michele N, Gioacchino C (2013). Research and Development for Botanical Products in Medicinals and Food Supplements Market. Evid-Based Complement. Altern. Med. Article ID 649720, 6p.

 
 

Mohire NC, Salunke VR, Bhinse SB, Yadav AV (2007). Cardiotonic activity of aqueous extract of heartwood of Pterocarpus marsupium. Indian J. Exper. Biol. 45(6):532-537.

 
 

Moshi MJ (2007). Brine shrimp toxicity evaluation of some Tanzanian plants used raditionally for the treatment of fungal infections. Afr.J.Tradit. Complement. Altern. Med. 4:219-225.

 
 

Newman DJ, Cragg GM, Snader KM (2003). Natural Products as Sources of New Drugs. J. Nat. Prod. 66:1022-1103.
Crossref

 
 

Rang HP, Dale M, Ritter J (2001). Pharmacology, 4th ed.; Churchill Livingstone: New York, NY, USA, pp. 130-148.

 
 

Subramanion LJ, Zuraini YC, Yee LL, Lachimanan YL. Sreenivasan S (2011). Acute Oral Toxicity of Methanolic Seed Extract of Cassia fistula in Mice. Molecules P 16.

 
 

Thomas MC, MacIsaac RJ, Tsalamandris C, Power D, Jerums G (2003). Unrecognized anemia in patients with diabetes: a cross – sectional survey. Diabetes Care 26:1164-1169.
Crossref

 
 

Vaghasiya YK, Shukla VJ, Chanda SV (2011). Acute oral toxicity study of Pluchea a arguta boiss extract in mice. J. Pharmacol. Toxicol. 6:113-123.
Crossref

 

 


APA Adegbite, A. V., & Ezekwesili, C. N. (2017). Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats. African Journal of Biochemistry Research , 11(6), 28-33.
Chicago Adegbite A. Victor and Ezekwesili C. Nonyelum. "Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats." African Journal of Biochemistry Research 11, no. 6 (2017): 28-33.
MLA Adegbite A. Victor and Ezekwesili C. Nonyelum. "Effects of ethanol and aqueous leaf extracts of Pterocarpus mildbraedii on hematology parameters and cholesterol in albino rats." African Journal of Biochemistry Research 11.6 (2017): 28-33.
   
DOI 10.5897/AJBR2017.0930
URL http://academicjournals.org/journal/AJBR/article-abstract/84709A965044

Subscription Form