African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 52

A STUDY OF ULCER INDUCED STOMACH OF ALBINO RATS TREATED WITH IDOGU MIXTURE, A POTENT ANTI-ULCER HERBAL DRUG

Adediran OA
  • Adediran OA
  • Department of Medical Laboratory Science, University of Benin, Benin City, Edo State, Nigeria
  • Google Scholar
Avwioro OG
  • Avwioro OG
  • Faculty of Science, Delta State University Abraka, Delta State, Nigeria
  • Google Scholar
Funsho-Agun AG
  • Funsho-Agun AG
  • Department of Medical Laboratory, St David’s Hospital Owo, Ondo State Nigeria
  • Google Scholar


  •  Received: 01 March 2017
  •  Accepted: 01 April 2017
  •  Published: 30 April 2017

Abstract

Aim: The aim of this study was to assess the potency of the anti-ulcer drug, Idogun on the stomach of ulcer induced albino rats.

Method: Six groups of locally bred albino rats were used. Each group containing five rats of either sex were orally treated respectively with distilled water (ulcer control group), omeprazole 20mg/kg (reference group) and 100, 200, 400 and 800mg/kg extract of Idogun anti –ulcer mixture (experimental group). Rats were sacrificed one hour after oral administration of 1ml absolute ethanol to induce injury in the gastric mucosa.

Results: Tissue sections from ulcer induced rats contained haemorrhage, dense infiltration by mixed inflammatory cells and extensive ulceration. These features were absent in the ulcer induced rats that were subsequently treated with the Idogun mixture. Mild tissue edema and presence of inflammatory cells were observed in the omeprazole treated section.

Conclusion: Idogun anti-ulcer herbal mixture is a potent anti-ulcer drug.

Key words: Idogun mixture, Stomach ulcer, Herbal