African Journal of Pure and Applied Chemistry
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Article Number - 22B6CCA61298


Vol.10(5), pp. 56-62 , October 2016
DOI: 10.5897/AJPAC2016.0701
ISSN: 1996-0840



Full Length Research Paper

Copper-paracetamol complexes: Promising lead antibacterial drug candidates



Samuel Mawuli Adadey
  • Samuel Mawuli Adadey
  • Department of Biochemistry, Cell and Molecular Biology, University of Ghana.
  • Google Scholar
Justice Kwabena Sarfo
  • Justice Kwabena Sarfo
  • Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Google Scholar







 Received: 23 August 2016  Accepted: 07 October 2016  Published: 31 October 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Antibiotic resistance by microorganisms has triggered the need to discover new antibiotics to replace the old ones. The study was designed to prepare copper-paracetamol complexes which will serve as lead compounds towards the discovery of novel antibiotics. Copper sulphate was reacted with paracetamol in the presence of sodium nitrate in borate buffer to give products which were separated into three layers when extracted with a set of organic solvents. The topmost, third layer was separated and further washed with 1:1:1 petroleum ether, ethanol and benzene to obtain a yellow extract. The first and second layers were also air dried to obtain products 1 and 2. The maximum wavelength of absorption of products 1, 2, yellow extract and paracetamol were 250, 350, 280 and 300 nm respectively. The infrared absorption peaks suggested that, the metal coordination products formed were different from the reactants (paracetamol and cupper). The atomic absorption spectra of the extracts further indicated the association of copper with paracetamol to form the coordination complexes. Products 1, 3 and the yellow extract inhibited E. coli and staphylococcus growth. In all four products were separated and their possible structures have been proposed in the text.

 

Key words: Copper, paracetamol, coordination complex, antibacterial and drug leads.

Beckmann U, Brooker S (2003). Cobalt(II) complexes of pyridazine or triazole containing ligands: Spin-state control. Coordination Chem. Rev. pp. 17-29.
Crossref

 

Bhattacharya A, Purohit VC, Suarez V, Tichkule R, Parmer G, Rinaldi F (2006). One-step reductive amidation of nitro arenes: Application in the synthesis of Acetaminophen? Tetrahedron Lett. 47:1861-1864.
Crossref

 
 

Diana E, Chierotti MR, Marchese EMC, Croce G, Milanesio M, Stanghellini PL (2012). Blue and red shift hydrogen bonds in crystalline cobaltocinium complexes. New J. Chem. 36:1099.
Crossref

 
 

Farrell N (1989). Transition Metal Complexes as Drugs and Chemotherapeutic Agents. Met. Complexes Drugs Chemother. Agents 11:809–840.
Crossref

 
 

Hinz B, Brune K (2012). Paracetamol and cyclooxygenase inhibition: is there a cause for concern? Ann. Rheum. Dis. 71:20–25.
Crossref

 
 

Kimura E (1986). Distinctive Coordination Chemistry and Biological Relevance of Complexes with Macrocyclic Oxo Polyamines. J. Coord. Chem. 15:1-28.
Crossref

 
 

Lawal A, Obaleye J (2007). Synthesis, characterization and antibacterial activity of aspirin and paracetamolmetal complexes. Biokemistri 19.

 
 

Mairbäurl H, Weber RE (2012). Oxygen transport by hemoglobin. Compr. Physiol. 2:1463-1489.
Crossref

 
 

Mewis RE, Archibald SJ (2010). Biomedical applications of macrocyclic ligand complexes. Coord. Chem. Rev. 254:1686-1712.
Crossref

 
 

Miller BS, Leaper R, Calderan S, Gedamke J (2014). Red shift, blue shift: Investigating doppler shifts, blubber thickness, and migration as explanations of seasonal variation in the tonality of antarctic blue whale song. PLoS One 9.
Crossref

 
 

Mukherjee R (2000). Coordination chemistry with pyrazole-based chelating ligands: molecular structural aspects. Coord. Chem. Rev. 203:151-218.
Crossref

 
 

Nour El-Dien FA, Zayed MA, Mohamed GG, El-Nahas RG (2005). Two spectrophotometric assays for dopamine derivatives in pharmaceutical products and in biological samples of schizophrenic patients using copper tetramine complex and triiodide reagent. J. Biomed. Biotechnol. pp. 1-9.
Crossref

 
 

Razeghi M (2009). Fundamentals of solid state engineering, 3rd edition.

 
 

Reedijk J (2008). Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes. Platin. Met. Rev. 52:2-11.
Crossref

 
 

Smit H, van Der Goot H, Nauta WT, Pijper PJ, Balt S, de Bolster MW, Stouthamer AH, Verheul H, Vis RD (1980). Mode of action of copper complexes of some 2,2'-bipyridyl analogs on Paracoccus denitrificans. Antimicrob. Agents Chemother. 18:249-256.
Crossref

 

 


APA Adadey, S. M., & Sarfo, J. K. (2016). Copper-paracetamol complexes: Promising lead antibacterial drug candidates. African Journal of Pure and Applied Chemistry, 10(5), 56-62.
Chicago Samuel Mawuli Adadey and Justice Kwabena Sarfo. "Copper-paracetamol complexes: Promising lead antibacterial drug candidates." African Journal of Pure and Applied Chemistry 10, no. 5 (2016): 56-62.
MLA Samuel Mawuli Adadey and Justice Kwabena Sarfo. "Copper-paracetamol complexes: Promising lead antibacterial drug candidates." African Journal of Pure and Applied Chemistry 10.5 (2016): 56-62.
   
DOI 10.5897/AJPAC2016.0701
URL http://academicjournals.org/journal/AJPAC/article-abstract/22B6CCA61298

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