African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2084

Full Length Research Paper

Evaluation of wound healing activity of the polyherbal and Euphorbia hirta formulations

Kuldeep Ganju1* and A. K. Pathak2
1Principal, SIPTec, Gandhinagar, Bhopal, India. 2Department of Pharmacy, B.U., Bhopal, India.
Email: [email protected]

  •  Accepted: 26 July 2013
  •  Published: 08 September 2013

Abstract

Evaluation of wound healing activity of polyherbal and Euphorbia hirta formulations was done. The study aimed at preparing a polyherbal formulation containing equal proportions of ethanolic extract of Tridax procumbensEuphorbia hirtaEclipta alba, dried rhizome ofCurcuma longa and gel of Aloe barbadensis. Excision wound, incision wound and granulaoma wound models were studied. In excision wound model it was observed that 100% wound healing was found on 12th day of the experiment on application of 10% polyherbal ointment and 100% wound contraction was found on 16th day of application of 10% ointment of E. hirta. The results were statistically compared with control and found significant. Similarly, period of epithelilization, biochemical parameters and weight of granuloma tissues showed better results in the treated groups when compared with control in the studied wound models. Thus it is concluded that topical and oral formulations were found to contain significant wound healing activity.           

 

Key words: Excision wound, incision wound, granuloma.