African Journal of Pharmacy and Pharmacology
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Article Number - 37F4D2643723


Vol.8(12), pp. 342-345 , March 2014
https://doi.org/10.5897/AJPP2013.3950
ISSN: 1996-0816


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Full Length Research Paper

In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice



Olorunniyi, O. F*
  • Olorunniyi, O. F*
  • Department of Zoology, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria.
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O. A. Morenikeji
  • O. A. Morenikeji
  • Department of Zoology, University of Ibadan, Ibadan, Oyo State, Nigeria
  • Google Scholar







 Received: 21 November 2013  Accepted: 14 February 2014  Published: 29 March 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Antimalarial activity of the crude aqueous leaf extract of Pyrenacantha staudtii was evaluated using chloroquine-sensitive Plasmodium berghei infection in mice with an objective to finding scientific evidence for the use of the plant as traditional antimalarial remedy in Ido/Osi LGA of Ekiti state, Nigeria. The crude aqueous extract of P. staudtii Engl. (Icacinaceae) (100, 200 and 500 mg/kg) was administered orally to mice infected with P. berghei in 4 days suppressive test. The antiplasmodial effect during the test of the plant in blood was determined and the extract at these doses induced 58.0 to 63.4% activity in comparison with untreated (negative) control group. Chloroquine produced 100% activity. The antimalarial activity showed by P. staudtii during the test justifies its use in traditional medicine for treating of malaria in the area.

 

Key words: Pyrenacantha staudtii, herb, malarial, anti-malarial, Ido/Osi, Ekiti, Plasmodium berghei, mice.

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APA Olorunniyi, O.F., & Morenikeji, O.A. (2014). In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice. African Journal of Pharmacy and Pharmacology, 8(12), 342-345.
Chicago Olorunniyi, O. F. and O. A. Morenikeji. "In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice." African Journal of Pharmacy and Pharmacology 8, no. 12 (2014): 342-345.
MLA Olorunniyi, O. F. and O. A. Morenikeji. "In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice." African Journal of Pharmacy and Pharmacology 8.12 (2014): 342-345.
   
DOI https://doi.org/10.5897/AJPP2013.3950
URL http://academicjournals.org/journal/AJPP/article-abstract/37F4D2643723

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