African Journal of Pharmacy and Pharmacology
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Article Number - 3FF369F67097


Vol.11(45), pp. 567-572 , December 2017
DOI: 10.4851/AJPP2017.4851
ISSN: 1996-0816



Full Length Research Paper

In vivo antioxidative activity of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside isolated from Panzeria alaschanica



BAO Ming-Lan
  • BAO Ming-Lan
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
  • Google Scholar
WANG Qing-Hu
  • WANG Qing-Hu
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
  • Google Scholar
HAO Jun-sheng
  • HAO Jun-sheng
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
  • Google Scholar







 Received: 18 September 2017  Accepted: 04 December 2017  Published: 08 December 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Our objective was to assess in vivo antioxidative potential of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside (TFGN) isolated from Panzeria alaschanica in a diabetic rat model. The diabetes and the following oxidative stress were induced by intraperitoneal administration of streptozotocin. The effects of TPGN (60 mg/kg) on the plasma concentration of malondialdehyde (MDA) and plasma fat-soluble antioxidants (co-enzyme Q9, α-and γ-tocopherol) were measured as a parameter of oxidative damage and markers of antioxidant defence, respectively. The level of MDA in plasma was reduced to the same level as in healthy control animals. A significant decrease was observed in the plasma α-tocopherol level in the oxidative stress group compared to the healthy controls.

Key words: Panzeria alaschanica, diabetes mellitus model, antioxidant, 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside.

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APA Ming-Lan, B., Qing-Hu, W. and Jun-sheng, H. (2017). In vivo antioxidative activity of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside isolated from Panzeria alaschanica. African Journal of Pharmacy and Pharmacology, 11(45), 567-572.
Chicago BAO Ming-Lan, WANG Qing-Hu and HAO Jun-sheng. "In vivo antioxidative activity of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside isolated from Panzeria alaschanica." African Journal of Pharmacy and Pharmacology 11, no. 45 (2017): 567-572.
MLA BAO Ming-Lan, WANG Qing-Hu and HAO Jun-sheng. "In vivo antioxidative activity of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside isolated from Panzeria alaschanica." African Journal of Pharmacy and Pharmacology 11.45 (2017): 567-572.
   
DOI 10.4851/AJPP2017.4851
URL http://academicjournals.org/journal/AJPP/article-abstract/3FF369F67097

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