African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2084

Full Length Research Paper

In vivo antioxidative activity of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside isolated from Panzeria alaschanica

BAO Ming-Lan
  • BAO Ming-Lan
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
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WANG Qing-Hu
  • WANG Qing-Hu
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
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HAO Jun-sheng
  • HAO Jun-sheng
  • College of Traditional Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, China.
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  •  Received: 18 September 2017
  •  Accepted: 04 December 2017
  •  Published: 08 December 2017

Abstract

Our objective was to assess in vivo antioxidative potential of 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside (TFGN) isolated from Panzeria alaschanica in a diabetic rat model. The diabetes and the following oxidative stress were induced by intraperitoneal administration of streptozotocin. The effects of TPGN (60 mg/kg) on the plasma concentration of malondialdehyde (MDA) and plasma fat-soluble antioxidants (co-enzyme Q9, α-and γ-tocopherol) were measured as a parameter of oxidative damage and markers of antioxidant defence, respectively. The level of MDA in plasma was reduced to the same level as in healthy control animals. A significant decrease was observed in the plasma α-tocopherol level in the oxidative stress group compared to the healthy controls.

Key words: Panzeria alaschanica, diabetes mellitus model, antioxidant, 5,7,4'-trihydroxyflavone-7-O-(6''-O-[E]-coumaroyl)-β-glucopyranoside.