African Journal of Pharmacy and Pharmacology
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Article Number - BE4E8CA30302


Vol.5(14), pp. 1669 - 1673 , October 2011
https://doi.org/10.5897/AJPP11.117
ISSN: 1996-0816


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Full Length Research Paper

In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre


O. S. Olorunnisola* and A. J. Afolayan




School of Biological Sciences, University of Fort Hare, Alice 5700, South Africa.


Email: [email protected]






 Accepted: 16 September 2011  Published: 15 October 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre were tested in vivo for anti-malarial activity in Swiss albino mice inoculated with chloroquine resistant Plasmodium berghei NK 67 strain. The two extracts exhibited a significant (p>0.05) dose dependant anti-plasmodial activities in isolation and when combined in the 4-days curative standard test with a high mean of survival time. Although, the standard drug, Arthemether - lumefartrin, showed the highest antimalaria potency (81.4%), those of the leaf (74.4%) and root extracts (54.1%) in isolation and combination (63.4%) compared favorably. The leaf extract demonstrated higher antimalarial potency than the root or combination.  The two extracts also produced a significant (p>0.05) positive effect on the weight and hematology values in the treated animals. Phytochemical screening of the plant (leaf and the root extracts) reveals the presences of flavonoids, steroids, terpenoids, tannins and alkaloids. The anti-plasmodia activity of these plant extract might be attributed to these phytochemicals compounds. The results showed that the leaf and root of S. jollyanum possesses an anti-malarial activity which was effective against chloroquine resistance strain. This work has validated the traditional uses of S. jollyanum root extract in the treatment of malaria and also reported for the first time the anti-malarial property of the S. jollyanun leaf extract.

 

Key words: Sphenocentrum jollyanumPlasmodium berghei, Arthemther lumefartrin, hematological parameter, anti-plasmodium.


APA (2011). In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre. African Journal of Pharmacy and Pharmacology, 5(14), 1669 - 1673.
Chicago O. S. Olorunnisola and A. J. Afolayan. "In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre." African Journal of Pharmacy and Pharmacology 5, no. 14 (2011): 1669 - 1673.
MLA O. S. Olorunnisola and A. J. Afolayan. "In vivo anti-malaria activity of methanolic leaf and root extracts of Sphenocentrum jollyanum Pierre." African Journal of Pharmacy and Pharmacology 5.14 (2011): 1669 - 1673.
   
DOI https://doi.org/10.5897/AJPP11.117
URL http://academicjournals.org/journal/AJPP/article-abstract/BE4E8CA30302

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