African Journal of Pharmacy and Pharmacology
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Article Number - E9BC18965634


Vol.11(31), pp. 368-376 , August 2017
DOI: 10.5897/AJPP2017.4810
ISSN: 1996-0816



Full Length Research Paper

Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats



Ujowundu, C.O.
  • Ujowundu, C.O.
  • Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar
Igwe, C.U.
  • Igwe, C.U.
  • Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar
Alisi, C.S.
  • Alisi, C.S.
  • Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar
Nwaogu, L.A.
  • Nwaogu, L.A.
  • Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar
Ogbuagu, H.D.
  • Ogbuagu, H.D.
  • Department of Environmental Technology, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar
Onwuliri, V.A.1
  • Onwuliri, V.A.1
  • Department of Biochemistry, Federal University of Technology, Owerri, Nigeria.
  • Google Scholar







 Received: 20 March 2017  Accepted: 25 May 2017  Published: 22 September 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl4) induced toxicity. Twenty five male Wistar albino rats were grouped and treated, thus: group I served as normal control, groups II, IV and V were given single dose of 1.2 ml CCl4/kg body weight (bwt). Groups IV and V were administered 1.4 and 2.8 ml AB/kg bwt, respectively, while group III animals were administered 1.4 ml AB/kg bwt. Results obtained showed significant (p<0.05) increase in lipid peroxidation and in activities of liver function enzymes, reductions in glutathione concentration and activities of catalase, glutathione peroxidase and reductase in groups administered AB and CCl4 only as well as in groups treated with AB after CCl4 exposure. These observations indicate manifestation of oxidative stress induced by excessive consumption of high percentage alcoholic content of the bitter. Similarly, the result trends of other antioxidant parameters studied indicated significant oxidative damage and thus the inability of the alcoholic bitter to ameliorate xenobiotics induced damage.

Key words: Alcohol, bitters, toxicants, oxidative stress, hepatotoxicity, xenobiotics.

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APA Ujowundu, C.O., Igwe, C.U., Alisi, C.S., Nwaogu, L.A., Ogbuagu, H.D., & Onwuliri, V.A. (2017). Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats. African Journal of Pharmacy and Pharmacology, 11(31), 368-376.
Chicago Ujowundu, C.O., Igwe, C.U., Alisi, C.S., Nwaogu, L.A., Ogbuagu, H.D. and Onwuliri, V.A.. "Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats." African Journal of Pharmacy and Pharmacology 11, no. 31 (2017): 368-376.
MLA Ujowundu, et al. "Detoxification potentials of an alcoholic bitter on carbon tetrachloride-induced oxidative damage in wistar albino rats." African Journal of Pharmacy and Pharmacology 11.31 (2017): 368-376.
   
DOI 10.5897/AJPP2017.4810
URL http://academicjournals.org/journal/AJPP/article-abstract/E9BC18965634

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