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Article Number - AE2589412544


Vol.7(4), pp. 90-101 , October 2012
DOI: 10.5897/BMBR11.027
ISSN: 1538-2273



Review

Role of proteases in cancer: A review


Syed Rakashanda, Farukh Rana, Shaista Rafiq, Akbar Masood and Shajrul Amin*




Department of Biochemistry, University of Kashmir, Srinagar (J&K), 190006, India.


Email: shajrul@rediffmail.com






 Accepted: 19 July 2012  Published: 31 October 2012

Copyright © 2012 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Proteases in normal cells are important in carrying out biological processes. In living systems, a balance between proteases and their anti-proteases occur, and disturbance of balance leads to many diseases like cancer. Steps starting from tumor initiation, growth, metastasis and finally invasion into some other site involve all five classes of proteases: serine, cysteine, aspartate, threonine and matrix metalloproteases. The activity of set of peptides in cancer progression is known as cancer ‘degradome’. A great number of reports have shown a correlation between the activity of lysosomal cysteine proteases and tumor progression. Trypsin, one of the typical well-known digestive serine protease has also been found to be involved in various cancers and promotes proliferation, invasion and metastasis. The colorectal cancer with trypsin expression has poor prognosis and shorter disease free survival. Protease involvement in cancer suggests the use of protease inhibitors as anticancer drugs. In this review, we will focus on role of proteases in various processes of carcinogenesis and some protease inhibitor based drugs.

 

Key words: Proteases, protease inhibitors, cathepsins, matrix metalloproteases, threonine proteases, trypsin, tumor.


APA (2012). Role of proteases in cancer: A review. Biotechnology and Molecular Biology Reviews, 7(4), 90-101.
Chicago Syed Rakashanda, Farukh Rana, Shaista Rafiq, Akbar Masood and Shajrul Amin. "Role of proteases in cancer: A review." Biotechnology and Molecular Biology Reviews 7, no. 4 (2012): 90-101.
MLA Syed Rakash, et al. "Role of proteases in cancer: A review." Biotechnology and Molecular Biology Reviews 7.4 (2012): 90-101.
   
DOI 10.5897/BMBR11.027
URL http://academicjournals.org/journal/BMBR/article-abstract/AE2589412544

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