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Article Number - 75C3D2B65583


Vol.8(2), pp. 14-18 , July 2017
https://doi.org/10.5897/CRO2015.0097
ISSN: 2141-2553


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Review

Platelet-mediated clumping adhesion phenotypes of P. falciparum-infected erythrocytes: A review



Frank G Onyambu
  • Frank G Onyambu
  • Department of Chemistry and Biochemistry, Moi University P.O. Box 3900 Eldoret, Kenya.
  • Google Scholar
Stephen B Tanui
  • Stephen B Tanui
  • Moi Teaching and Referral Hospital, P.O. Box 3 Eldoret, Kenya.
  • Google Scholar
Dominic S. O. Alwala
  • Dominic S. O. Alwala
  • Moi Teaching and Referral Hospital, P.O. Box 3 Eldoret, Kenya.
  • Google Scholar
Kiptanui Chebii
  • Kiptanui Chebii
  • Department of Human Pathology, Moi University P.O. Box Eldoret, Kenya.
  • Google Scholar
Bethwel K. Kigen
  • Bethwel K. Kigen
  • Moi Teaching and Referral Hospital, P.O. Box 3 Eldoret, Kenya.
  • Google Scholar







 Received: 31 July 2015  Accepted: 28 April 2017  Published: 31 July 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Malaria is a leading cause of morbidity and mortality in the world. In general, malaria is easily treated but in a subset of cases it develops to severe disease. Severe malaria has a high rate of mortality even with the best available care. This creates the need for intensive research to fully characterise the pathogenesis of the disease in order to create future novel therapies. One of the hallmarks of malaria infections is its ability to adhere to specific sites in the body leading to severe disease syndromes such as cerebral malaria and pregnancy associated malaria. In this review, the platelet-mediated clumping adhesion phenotypes of malaria-infected erythrocytes were discussed in the context of infected erythrocyte adhesion phenotypes such as cytoadhesion and rosetting. Platelet-mediated clumping refers to a phenomenon of P. falciparum-infected erythrocytes whereby they agglutinate to form large aggregates held together by activated platelets. This unique phenotype is important because it has been associated with severe malaria in both children and adults in diverse geographical and transmission settings. The precise mechanisms by which platelet-mediated clumping occurs are yet to be precisely described. The platelet receptors implicated in this phenotype include CD36, P-Selectin and gC1qR.  The parasite derived ligands that mediate this phenotype are yet to be described.

 

Key words: Malaria, platelets, platelet-mediated clumping, infections.

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APA Onyambu, F. G., Tanui, S. B., Alwala, D. S. O., Chebii, K., & Kigen, B. K. (2017). Platelet-mediated clumping adhesion phenotypes of P. falciparum-infected erythrocytes: A review. Clinical Reviews and Opinions, 8(2), 14-18.
Chicago Frank G Onyambu, Stephen B Tanui, Dominic S. O. Alwala, Kiptanui Chebii and Bethwel K. Kigen. "Platelet-mediated clumping adhesion phenotypes of P. falciparum-infected erythrocytes: A review." Clinical Reviews and Opinions 8, no. 2 (2017): 14-18.
MLA Frank G Onyambu, et al. "Platelet-mediated clumping adhesion phenotypes of P. falciparum-infected erythrocytes: A review." Clinical Reviews and Opinions 8.2 (2017): 14-18.
   
DOI https://doi.org/10.5897/CRO2015.0097
URL http://academicjournals.org/journal/CRO/article-abstract/75C3D2B65583

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