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Article Number - A773B8E3689


Vol.1(2), pp. 021-025 , November 2009

ISSN: 2141-2553



Full Length Research Paper

Histological signs of oligodendroglioma in the brain of rats fed with diet containing yaji: The complex Nigerian suya meat sauce



A. O. Nwaopara
  • A. O. Nwaopara
  • Department of Anatomy, Ambrose Alli University Ekpoma, Edo State, Nigeria.
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C. I. P. Anibeze
  • C. I. P. Anibeze
  • Department of Anatomy, Abia State University, Uturu, Abia State, Nigeria.
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F. C. Akpuaka
  • F. C. Akpuaka
  • Department of Anatomy, Abia State University, Uturu, Abia State, Nigeria.
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 Accepted: 05 November 2009  Published: 30 November 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Yaji is a complex mixture of groundnut cake powder, additives, spices and salt. The production and consumption of Yaji is not regulated despite the excitotoxic, apoptotic and tumourigenic potentials of some of its active principles. This has been the basis for several scientific investigations aimed at determining the effect of Yaji on different body organs. The present study on the brain is intended to determine its tumourigenic potentials. Eighteen weeks old white albino rats of an average weight of 170 g were used for this study. They were divided into eight groups (A - H) of three subgroups each. Subgroup 1, 2 and 3 represents experimental periods of 2, 4 and 6 weeks respectively. Group A rats served as control and were fed with normal feed (growers mash) only, while groups B - H served as the test groups and were fed with normal feed plus graded levels of Yaji(B, 10%; C, 20%; D, 30%; E, 40%; F, 50%; G, 60%; and H, 70%). At the end of the respective experimental periods, test group rats were sacrificed in order to harvest the brain tissues for tissue processing. We observed that the stained brain tissue micrographs from test group F3 (6 weeks; 50%) presented features that were histologically similar to those of oligodendroglioma and the incidence appears to be high dosage/duration dependent. This result implicates the active principles in Yajiand suggests that at high doses, Yaji is capable of inducing brain tissue damage as well as tumour formation.

 

Key wordsSuyaYaji, additives, spices, oligodendroglioma.


APA (2009). Histological signs of oligodendroglioma in the brain of rats fed with diet containing yaji: The complex Nigerian suya meat sauce. Clinical Reviews and Opinions, 1(2), 021-025.
Chicago A. O. Nwaopara, C. I. P. Anibeze and F. C. Akpuaka. "Histological signs of oligodendroglioma in the brain of rats fed with diet containing yaji: The complex Nigerian suya meat sauce." Clinical Reviews and Opinions 1, no. 2 (2009): 021-025.
MLA A. O. Nwaopara, C. I. P. Anibeze and F. C. Akpuaka. "Histological signs of oligodendroglioma in the brain of rats fed with diet containing yaji: The complex Nigerian suya meat sauce." Clinical Reviews and Opinions 1.2 (2009): 021-025.
   
DOI
URL http://academicjournals.org/journal/CRO/article-abstract/A773B8E3689

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