International Journal of Genetics and Molecular Biology
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Article Number - 2E494E417303

Vol.5(5), pp. 54-63 , October 2013
DOI: 10.5897/IJGMB11.020
ISSN: 2006-9863


Role of apoptosis-related factors in follicular atresia

Basak Gumus, Sevtap Kilic and Ebru Zulfikaroglu*

Zekai Tahir Burak Women's Health Care Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey


 Accepted: 02 July 2012  Published: 30 October 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0

Follicular atresia is the term used for the fate of follicles which undergo degenerative changes before rupturing during ovulation. Recent studies suggest that granulosa cell apoptosis play a major role in follicular atresia. The factors which lead the cell to apoptosis and which protect the cell death, still remain complicated and more studies are needed to elucidate the whole process. Here in this review, we aimed to simplify the factors and mechanisms taking place in granulosa cell apoptosis, to make the process more understandable.


Key words: Granulosa cell, apoptosis, follicular atresia.


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APA (2013). Role of apoptosis-related factors in follicular atresia. International Journal of Genetics and Molecular Biology, 5(5), 54-63.
Chicago Basak Gumus, Sevtap Kilic and Ebru Zulfikaroglu. "Role of apoptosis-related factors in follicular atresia." International Journal of Genetics and Molecular Biology 5, no. 5 (2013): 54-63.
MLA Basak Gumus, Sevtap Kilic and Ebru Zulfikaroglu. "Role of apoptosis-related factors in follicular atresia." International Journal of Genetics and Molecular Biology 5.5 (2013): 54-63.
DOI 10.5897/IJGMB11.020

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