International Journal of Medicine and Medical Sciences
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Article Number - 259BCB666739


Vol.9(12), pp. 158-173 , December 2017
DOI: 10.5897/IJMMS2017.1310
ISSN: 2006-9723



Full Length Research Paper

External application of moisture exposed burn ointment for phlebitis: A meta-analysis of randomized controlled trials



Lian Liu
  • Lian Liu
  • Nursing School, Southwest Medical University, China.
  • Google Scholar
Song Wei Su
  • Song Wei Su
  • Basic School, Guangzhou University of Chinese Medicine, China.
  • Google Scholar
Ping Zhou
  • Ping Zhou
  • Department of Oncology, the Affiliated Hospital of Southwest Medical University, China.
  • Google Scholar
Ru Song
  • Ru Song
  • Department of Orthopedic, the Affiliated Hospital of Southwest Medical University, China.
  • Google Scholar
Hong Yan Sun
  • Hong Yan Sun
  • Nursing School, Southwest Medical University, China.
  • Google Scholar







 Received: 26 April 2017  Accepted: 13 September 2017  Published: 31 December 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


To evaluate the therapeutic effects of moisture exposed burn ointment (MEBO) on phlebitis, seven electronic databases where checked until September, 2016 for randomized controlled trials (RCTs) of MEBO on phlebitis. Risk of bias was assessed using Cochrane handbook guidelines. Thirty eight randomized controlled trials met the inclusion criteria in which the aggregated results indicated that comparison revealed significant differences in total effectiveness rate of MEBO versus conventional therapy (RR=1.27, 95% confidence interval [CI]=1.06, 1.52, and P=0.009), and there were some beneficial evidence regarding the effects on reducing incidence of phlebitis MEBO versus conventional therapy in preventing phlebitis (RR=2.73, 95% confidence interval [CI]=1.94, 3.85, and P<0.00001). The evidence that MEBO is an effective treatment for phlebitis is encouraging, but not conclusive due to the low methodological quality of the RCTs. Therefore, more high-quality RCTs with larger sample sizes are required.
 
Key words: External application of moisture exposed burn ointment, prevention and (or) treatment, phlebitis.

Aljitawi O, Shabaneh B, Whitaker J (2005). Bilateral Upper Extremity Thrombophlebitis Related to Intravenous Amiodarone: A Case Report. Southern Med. J. 98(8):813-816.
Crossref

 

Allam AM, Mostafa W, Zayed E, El-Gamaly J (2007). Management of the acute partial-thickness burned hand; moist exposed burn ointment or silver sulphadiazine cream both combined with a polyethylene bag. Ann. Burn Fire Disaster 20(3):144.

 
 

Al-Meshaan M, Abdul HM, Quider T, Al-Sairafi A, Dham R (2008). Role of Mebo (Moist Exposed Burn Ointment) in the Treatment of Fournier'S Gangrene. Ann. burns fire Disaster 21(1):20.

 
 

Al-Numairy A (2000). Clinical Use of MEBO in Wounds Management in UAE. Int. J. Cosmet. Surg. Aesthet. Dermatol. 2(1):27-33.
Crossref

 
 

An Y, Wu MH, Li Y, Peng H, Yang XH (2008). Application of MEBO in Preventing Chemotherapy Phlebitis in 65 Cases. Available at: 

View

 
 

Ang E, Lee ST, Gan CS, Chan YH, Cheung YB, Machin D (2003). Pain control in a randomized, controlled, clinical trial comparing moist exposed burn ointment and conventional methods in patients with partial-thickness burns. J. Burn. Care Rehabil.24:289-296.
Crossref

 
 

Ang ES, Lee ST, Gan CS(2002).The role of alternative therapy in the management of partial thickness burns of the face--experience with the use of moist exposed burn ointment (MEBO) compared with silver sulphadiazine. J. Ann. Acad. Med. Singapore. 29(1):7-10.

 
 

Atiyeh BS, Dham R, Kadry M, Abdallah AF, Al-Oteify M, Fathi O, Samir A (2002). Benefit–cost analysis of moist exposed burn ointment. Burns 28(7):659-663.
Crossref

 
 

Boyce BA, Yee BH (2012). Incidence and Severity of Phlebitis in Patients Receiving Peripherally Infused Amiodarone. Crit. Care Nurs. 32(4):27-34.
Crossref

 
 

Chen PF, Shen YS (2008). Application of MEBO MEBO in the Phlebitis Induced by Mannitol. Available at: 

View

 
 

Chen F (2007). Effect of MEBO on preventing and treating phlebitis induced by sodium aescinate. Available at: 

View

 
 
 

Chen Y (2014). MEBO moisturizing burn cream applied to the clinical evaluation of fat emulsion exudative phlebitis. Available at: 

View

 
 

Di Nisio M, Peinemann F, Porreca E, Anne WR (2015).Treatment for superficial infusion thrombophlebitis of the upper extremity. Cochrane Database Systematic. Reviews. Available at: 

View
Crossref

 
 

El-Hadidy MR, El-Hadidy AR, Bhaa A, Asker SA, Mazroa SA (2014). Role of epidermal stem cells in repair of partial-thickness burn injury after using Moist Exposed Burn Ointment (MEBO ®) histological and immunohistochemical study. Tissue Cell 46:144-151.
Crossref

 
 

Evangelos T,Abdulazeez S (2014). Improving the frequency of visual infusion phlebitis (VIP) scoring on an oncology ward. BMJ Qual. Improv. Rep. 3(1):u2054-w2364.

 
 

Ezzo J, Berman BM, Vickers AJ, Linde K(1998). Complementary medicine and the Cochrane Collaboration. Jama, 280(18):1628-1630.
Crossref

 
 

Feng X, Zang H (2012). Efficacy of topical application of MEBO in the treatment of phlebitis induced by infusion. 

 
 

Galgon RE, Strube P, Heier J, Groth J, Wang SJ, Schroeder KM (2015).Magnesium Sulfate with Lidocaine for Preventing Propofol Injection Pain: A Randomized, Double-Blind, Placebo Controlled Trial. J. Anesthesiol. 29(2):206-211.

 
 

Guan C (2010). Effect of MEBO in treating phlebitis induced by peripheral venous catheterization.Available at: 

View

 
 

Guan WJ (2006). Treatment of 50 Cases of Chemotherapy Phlebitis with MEBO. Available at: 

View

 
 

Guo G (2016). Preventive effect of MEBO treated with MEBO. Available at: 

View

 
 

Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, Savović J, Schulz KF, Weeks L, Sterne JA (2011). The cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ 343:d5928.
Crossref

 
 

Hindy AMGAD (2009). Comparative study between sodium carboxymethyl-cellulose silver, moist exposed burn ointment, and saline-soaked dressing for treatment of facial burns. Ann. burn Fire Disaster 22(3):131.

 
 

Hu Y, He XB, Huang H (2012). Efficacy of MEBO in the treatment of drug extravasation after chemotherapy. Available at: 

View

 
 

Huang A, Kao L, Zeng Y (2008). External application of MEBO in treatment of vinorelbine-induced phlebitis (leakage injury).Available at: 

View

 
 

Huang YP, Huang LL, Chen HP (2009). Efficacy of MEBO in treating 50 cases of chemotherapy phlebitis. Available at: 

View

 
 
 

Jewo PI, Fadeyibi IO ,Babalola OS, Saalu LC, Benebo AS, Izegbu MC, Ashiru OA(2009).A Comparative study of the wound healing

 
 

Johnson JL, He Y, Yalkowsky SH (2003). Prediction of Precipitation-Induced Phlebitis: A Statistical Validation of an In Vitro Model. J. Pharm. Sci. 92(8):1574-1581.
Crossref

 
 

Ju HR (2011) Efficacy of MEBO in treating phlebitis induced by amiodarone injection.

 
 

Kim MH, Young A, Han SH, Kim JH, Hwang JW, Jeon YT (2015). The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: A randomized controlled trial. J. Clin. Anesth. 27:595-601.
Crossref

 
 

Kohno E, Murase S, Nishikata M (2008). Research Paper Methods of preventing vinorelbine-induced phlebitis: an experimental study in rabbits. Int. J. Med. Sci. 5(4)218-223.
Crossref

 
 

Leal AD, Kadakia KC, Looker S, Hilger C, Sorgatz K, Anderson K, Jacobson A, Grendahl D, Seisler D, Hobday T, Loprinzi CL (2014). Fosaprepitant-induced phlebitis: a focus on patients receiving doxorubicin/cyclophosphamide therapy. Support Care Cancer 22(5):1313-1317.
Crossref

 
 

Li B, Jiang JX, Li CX (2015). Efficacy of MEBO MEBO in treating chemotherapy - induced skin lesions and phlebitis. Available at: 

View

 
 

Li SD, Zhang XL, Cai XS (2009). Observation of the effect of topical application of MEBO in preventing phlebitis by intravenous. at: 

View

 
 

Li XZ (2009). Efficacy of External Application of MEBO in Treating Phlebitis. Available at: 

View

 
 

Li YF, Wang J, Sun JL (2011). Therapeutic effect of MEBO MEBO in treating phlebitis induced by β-aescinate sodium. Available at: 

View

 
 

Lin YZ, Ye L, Ye LL, Chen LL (2013). Therapeutic effect of MEBO MEBO in preventing phlebitis caused by indwelling needle

 
 

Liu C ,Yang FL, Zhao XH (2014). Effect of MEBO in treating amiodarone phlebitis. Available at: 

View

 
 

Liu F, Chen D, Liao Y (2012). Apparatus on Phlebitis in a Neurological Intensive Care Unit: A Case-control Study. J. Intern. Med. Res. 40(6)2321-2326.
Crossref

 
 

Lu XM (2012). Effect of MEBO in treating phlebitis induced by amiodarone. Available at: 

View

 
 

Malach T, Jerassy Z, Rudensky B, Schlesinger Y (2006). Prospective surveillance of phlebitis associated with peripheral intravenous catheters. Am. J. Infect. Control 34(5):308-312.
Crossref

 
 

Meng GP, Meng GL (2006). Clinical Application of MEBO in Treating Intravenous Needle Combined with Phlebitis.Available at: 

View

 
 

Milutinović D, Simin D, Zec D (2015). Risk factor for phlebitis: A questionnaire study of nurses' perception. Rev. Lat. Am. Enfermagem. 23(4):677-684.
Crossref

 
 

Myrianthefs P, Karatzas S, Baltopoulos G (2005a). Complications, thrombophlebitis rates, and intravenous catheter replacement strategies. Infection 33(2):96-97.
Crossref

 
 

Myrianthefs P, Sifaki M, Samara I, Baltopoulos G (2005b). The epidemiology of peripheral vein complications: Evaluation of the efficiency of differing methods for the maintenance of catheter patency and thrombophlebitis prevention. J. Evaluation Clin. Pract. 11(1):85-89.
Crossref

 
 

Ray-Barruel G, Polit DF, Murfield JE, Rickard CM (2014). Infusion phlebitis assessment measures: a systematic review. J. Evaluation Clin. Pract. 20(2):191-202.
Crossref

 
 

Ren L (2014). Treatment of infusion phlebitis by MEBO external application: a report of 84 cases. Available at: 

View

 
 

See GJ, Chan YH, Lee-Hua Ng BN, Machin D (2001). Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. Medscape/General Med. 3(12):3-18.

 
 

Spiering M (2014).Peripheral Amiodarone-Related Phlebitis: An Institutional Nursing Guideline to Reduce Patient Harm. J. Infusion Nurs. 37(6):453-460.
Crossref

 
 

Sun QL, Tian M, Tian BB, Zhang QF, Ding ZG (2016). Efficacy of MEBO in preventing phlebitis induced by surgical indwelling needle. Available at: 

View

 
 

Tagalakis V, Kahn SR, Libman M, Blostein M (2002).The Epidemiology of Peripheral Vein Infusion Thrombophlebitis: A critical review. Am. J. Med. 113(2):146-151.
Crossref

 
 

Tang QL, Han SS, Feng J (2014). Moist exposed burn ointment promotes cutaneous excisional wound healing in rats involving VEGF and bFGF. Mol. Med. Rep. 9(4):1277-1282.
Crossref

 
 

Thürlimann B, Bachmann I (1992). Effective prevention of chemotherapy-induced phlebitis by low-dose heparin: A prospective randomised trial. Ann. Oncol. 3(4):311-313.
Crossref

 
 

Tsati E, Panayotou P, Ioannovich J (2004). Moist exposed burn therapy: evaluation of the wound healing process. An experimental model to assess the efficacy of local agents on wound repair in partial-and full-thickness wounds. European J. Plastic Surg. 27(4):171-177.
Crossref

 
 

Vincy LWS (2004) Comparison of Moist Exposed Burn Ointment (MEBO) with Silver Sulfadiazine (Ag-S) for the Treatment of Deep Burn Injury .Hong Kong Baptist University School of Chinese Medicine . Bachelor of Science (Hons) in Biomedical Science April. Available at: 

View

 
 

Wang Z, Ma LJ, Wang XB (2014).Cimetidine attenuates vinorelbine-induced phlebitis in mice by militating E-selectin expression. Cancer Chemother. Pharmacol. 74:239-247.
Crossref

 
 

Xie WR, Lin HY (2014). Nursing Analysis of MEBO MEBO in Treating

 
 

Xing YB, Zhang XQ, Chen YF (2012). Application of MEBO in the Infusion Infusion of Intravenous Infusion. Available at: 

View

 
 

Xu J, Bai ZY, Peng X (2013). Efficacy of MEBO MEBO in treating phlebitis. Available at: 

View

 
 

Yamamoto T, Mori K, Esaki T, Nakao J, Watanabe M (2016). Preventive effect of continuous cisternal irrigation with magnesium sulfate solution on angiographic cerebral v Y asospasms associated with aneurysmal subarachnoid hemorrhages: A randomized controlled trial . J. Neurosurg.124:18-26.
Crossref

 
 

Yan W, Shu-Qian W, Jing Qu (2009). Clinical Experience on Preventing Infant from Phlebitis Caused by the Application of Venous Indwelling Needle with MEBO. Available at: 

View

 

Yang S (2012). The effect of MEBO on the prevention of phlebitis caused by intravenous infusion of fusidic acid. Chinese J. Burn Urol. 13(6):495-496.

 

Yang XH (2012). Effect of MEBO in treating phlebitis induced by nimodipine. 

 
 

Yang XH, Huang JH, Chen JX (2005). Clinical Observation of MEBO's Scalds-plasters by Wet Compressing in the Treatment of Mannitol-induced Phlebitis. J. Hebei. Med. 11(6):562-563

 
 

Yang XQ, Yang JD, Zhang Q, Zhao X (2009). Effect of MEBO MEBO in Preventing 40 Cases of Phlebitis Caused by 5-Fu. 

 
 

Yao C (2008). Comparison of the Efficacy of External Application of MEBO in Treating Mechanical Phlebitis Caused by PICC Catheterization.

 
 

Yu CY, Song HM (2011). Therapeutic effect of MEBO MEBO in treating phlebitis induced by mannitol.  

 
 

Yu W, Li C, Prospect, Wu W, Zeng H (2007). Clinical Study on External Application of MEBO in Preventing Chemotherapy Phlebitis.  

 
 

Zhang HQ, Yip TP, Hui I, Lai V, Wong A (2005). Efficacy of moist exposed burn ointment on burns. J. Burn Care Res. 26(3):247-251.

 
 

Zhang YJ, Chen ZX, Liu YJ, Zhang YL(2001).Treating principles and methods of traditional Chinese medicine in treatment of peripheral vascular diseases. Journal of traditional Chinese medicine= Chung i tsa chih ying wen pan/sponsored by All-China Association of Traditional Chinese Medicine. Acad. Tradit. Chinese Med. 21(2):130-133.

 
 

Zhang ZX, Wang P,Zhang QS, Pan X, Zhao QX,Wang XK (2012).Original article Effects of anisodamine on the expressions of vascular endothelial growth factor and intercellular adhesion molecule 1 in experimental infusion phlebitis. Chin. Med. J. 125(2):300-305.

 
 

Zheng SH (2012). Experimental study of two methods for treatment of phlebitis induced by peripheral central venous catheter chemotherapy. 

 
 

Zhou D (2013). Clinical Application of MEBO in Preventing Chemotherapy Phlebitis. 

 
 

Yan Z, Qiong L (2008). Observation on effect of moist burn cream plus ice compress to prevent patients from Vinorelbine caused phlebitis [J]. Chinese Nurs. Res. 2:047.

 
 

Zhou YH (2013). Effect of magnesium sulfate wet dressing combined

 
 

Zhu AE (2004). Efficacy Observation and Experience of MEBO in Treating Chemotherapy Phlebitis. 

 

 


APA Liu, L., Su, S. W., Zhou, P., Song, R., & Sun, H. Y. (2017). External application of moisture exposed burn ointment for phlebitis: A meta-analysis of randomized controlled trials. International Journal of Medicine and Medical Sciences, 9(12), 158-173.
Chicago Lian Liu, Song Wei Su, Ping Zhou, Ru Song and Hong Yan Sun. "External application of moisture exposed burn ointment for phlebitis: A meta-analysis of randomized controlled trials." International Journal of Medicine and Medical Sciences 9, no. 12 (2017): 158-173.
MLA Lian Liu, et al. "External application of moisture exposed burn ointment for phlebitis: A meta-analysis of randomized controlled trials." International Journal of Medicine and Medical Sciences 9.12 (2017): 158-173.
   
DOI 10.5897/IJMMS2017.1310
URL http://academicjournals.org/journal/IJMMS/article-abstract/259BCB666739

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