International Journal of Medicine and Medical Sciences
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Article Number - 4438B2713


Vol.5(9), pp. 401-408 , September 2013
DOI: 10.5897/IJMMS2013.0960
ISSN: 2006-9723



Medicinal values of garlic: A review



Gebreselema Gebreyohannes
  • Gebreselema Gebreyohannes
  • Department of Biology, Faculty of Natural and Computational Sciences, University of Gondar, Ethiopia.
  • Google Scholar
Mebrahtu Gebreyohannes
  • Mebrahtu Gebreyohannes
  • Faculty of Veterinary Medicine, University of Gondar, Ethiopia
  • Google Scholar







 Accepted: 12 August 2013  Published: 01 September 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Garlic products are used as sources of medicine in many ways in human beings in their day today life. As a result, researchers from various disciplines are now directing their efforts towards discovering the medicinal values of garlic on human health. The main interest of researchers in the medicinal values of garlic is its broad-spectrum therapeutic effect with minimal toxicity. Garlic extract has antimicrobial activity against many genera of bacteria, fungi and viruses. Garlic contains a higher concentration of sulfur compounds which are responsible for its medicinal effects. The chemical constituents of garlic have also been investigated for treatment of cardiovascular disease, cancer, diabetes, blood pressure, atherosclerosis and hyperlipidaemia and highly praised by several authors. Therefore, this paper is reviewed to inspire and impress the young researchers about the medicinal values of garlic.

 

Key words: Allium sativum, immunity booster, antibacterial, antifungal, antiviral, anticancer

 

Abdullah TH, Kandil O, Elkadi A, Carter J (1988). Garlic revisited: therapeutic for the major diseases of our times? J Natl Med Assoc. 80:439-445.
PMid:3290502 PMCid:PMC2625738
 
Amin M, Segatoleslami S, Hashemzadeh M (2009). Antimycobacterial activity of partial purified extract of Allium ascalonicum. Jundishapur J Microbial. 2(4):144-147.
 
Ankri S, Miron T, Rabinkov A, Wilchek M, Mirelman D. (1997). Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob. Agents Chemother. 10:2286-2288.
 
Bajpai M, Pande A, Tewari SK, Prakash D (2005). Phenolic contents and antioxidant activity of some food and medicinal plants. Int. J. Food Sci. Nutr. 56(4):287-291.
http://dx.doi.org/10.1080/09637480500146606
PMid:16096138
 
Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW (2007). Hydrogen sulfide mediates the vasoactivity of garlic. PNAS. 104:17977-17982.
http://dx.doi.org/10.1073/pnas.0705710104
PMid:17951430 PMCid:PMC2084282
 
Bordia A (1981). Effect of garlic on blood lipids in patients with coronary heart disease. Am. J. Clin. Nutr. 34:2100-2103.
PMid:7293938
 
Borek C (2006). Garlic reduces dementia and heart-disease risk. J. Nutr. 136(3):810-812.
 
Bradley PR (1992). British herbal compendium: a handbook of scientific information on widely used plant drugs/published by the British Herbal Medicine Association and produced by its Scientific Committee. Bournemouth, Dorset. pp. 105-108.
 
Capraz M, Dilek M, Akpolat T.Garlic (2006). Hypertension and patient education. Int. J. Cardiol. 3:15-19.
 
Catia D, Alessia F, Andrea G (2011). The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review Ann 1st Super Sanità. 47(4):465-473.
 
Dehghani F, Merat M, Panjehshahin MR, Handjani F (2005). Healing effect of garlic extract on warts and corns. Int. J. Dermatol. 44:612-615.
http://dx.doi.org/10.1111/j.1365-4632.2004.02348.x
PMid:15985039
 
Delaha EC, Garagusi VF (1985). Inhibition of mycobacteria by garlic extracts Allium sativum. Antimicrob Agents Chemother. 27(4):485-486.
http://dx.doi.org/10.1128/AAC.27.4.485
PMid:4004189 PMCid:PMC180079
 
Dibua UE, Odo GE, Udengwu S (2010). Esimone CO. Cytotoxicity and antitubercular activity of Allium sativum and lantana camara against mycobacterial isolates from people living with HIV/AIDS. The Internet J. Infec. Diseas. 8(1):1-10.
 
Didry N, Dubreuil L, Pinkas, M (1992). Antimicrobial activity of naphthaquinones and Allium extracts combined with antibiotics. Pharm. Acta Helv. 67:148-151.
PMid:1438452
 
Dorant E, van den Brandt PA (1996). Goldbohm RA. A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogen. 17(3):477-484.
http://dx.doi.org/10.1093/carcin/17.3.477
 
Eidi A, Eidi M, Esmaeili E (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomed. 13(9):624-629.
http://dx.doi.org/10.1016/j.phymed.2005.09.010
PMid:17085291
 
Ernst E (1994). Fibrinogen: An important risk factor for atherothrombotic disease. Ann Med. 26:15-22.
http://dx.doi.org/10.3109/07853899409147322
PMid:8166985
 
Ernst E, Weihmayr T, Matrai A (1994). Garlic and blood lipids. Br. Med. J. 291:139.
http://dx.doi.org/10.1136/bmj.291.6488.139-b
 
Friedman T, Shalom A, Westreich M (2006) Self-inflicted garlic burns: our experience and literature review. Int. J. Dermatol. 45(10):1161-1163.
http://dx.doi.org/10.1111/j.1365-4632.2006.02860.x
PMid:17040429
 
Friesen N, Fritsch RM, Blattner FR (2006). Phylogeny and new intrageneric classification of Allium L. (Alliaceae) based on nuclear ribosomal DNA its sequences. Aliso. 22:372-395.
 
Fukao H, Yoshida H, Tazawa YI, Hada T (2007). Antithrombotic Effects of Odorless Garlic Powder both in vitro and in vivo. Biosci Biotechnol. Biochem. 7:21.
 
Galeone C, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, Giacosa A, La Vecchia C (2006). Onion and garlic use and human cancer. Am. J. Clin. Nutr. 84(5):1027-1032.
PMid:17093154
 
Hahn G (1996). In: Koch HP, Lawson LD, eds. Garlic: the science and therapeutic application of Allium sativum L and related species (2nd edn). Baltimore Williams and Wilkins. Pp1-24.
 
Hsing AW, Chokkalingam AP, Gao YT, Madigan MP, Deng J, Gridley G, Fraumeni JF Jr (2002). Allium vegetables and risk of prostate cancer: a population based study. Am. J. Med. 94(21):1648-1651.
 
Jaber MA, Al-Mossawi A (2007). Susceptibility of some multiple resistant bacteria to garlic extracts. Afr. J. Biotechnol. 6(6):771-776.
 
Jain RC (1998). Anti-tubercular activity of garlic oil. Indian Drug. 30:73-75.
 
Jeyaraj S, Shivaji G, Jeyaraj SD, Vengatesan A (2006). Effect of combined supplementation of fish oil with garlic pearls on the serum lipid profile in hypercholesterolemic subjects. Indian Heart J. 57(4):327-331.
 
Josling P (2001). Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv. Ther.18:189-193.
http://dx.doi.org/10.1007/BF02850113
PMid:11697022
 
Josling PA (2005). The heart of garlic Nature's aid to healing the human body, HEC Publishing, Chicago Illinois. pp 20.
 
Kalyesa R (1975). Screening of indigenous plants for antihelminthic action against human Ascaris lumbricoides. Indian J. Physiol. Pharmacol. 19:47-49.
 
Kao SH, Hsu CH, Su SN, Hor WT, Chang WH, Chow LP (2004). Identification and immunologic characterization of an allergen, alliin-lyase, from garlic (Allium sativum). J. Allergy Clin. Immunol. 113(1):161-168.
http://dx.doi.org/10.1016/j.jaci.2003.10.040
PMid:14713923
 
Kasuga S, Ushijima M, Morihara N, Itakura Y, Nakata Y (1999). Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice. Nippon Yakurigaku Zassh. 114:191-197.
http://dx.doi.org/10.1254/fpj.114.191
PMid:10553583
 
Lanzotti V (2006). The analysis of onion and garlic. J. Chromat. A. 12(1):3-22.
http://dx.doi.org/10.1016/j.chroma.2005.12.016
PMid:16388813
 
Lau BH (1991). Effect of odor modified garlic preparation on blood lipids. Nutr. Res. 7:139-149.
http://dx.doi.org/10.1016/S0271-5317(87)80026-X
 
Lau BH (2006). Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. Nutr. 136(3):765-768.
 
Lawson LD (1996). The composition and chemistry of garlic cloves and processed garlic. In: Koch HP, Lawson LD, eds. Garlic: the science and therapeutic application of Allium sativum L and related species (2nd edn). Baltimore: Williams and Wilkins. pp. 37-107.
PMid:8561141
 
Lawson LD (1998). Garlic: a review of its medicinal effects and indicated active compounds. In: Lawson LS, Bauer R, Editors, Phytomedicines of Europe: Chemistry and Biological Activity, ACS Symposium Series 691, Am. Chem. Soc. Washington. pp176-209.
 
Lawson LD, Wang ZYJ (1996). Changes in the organosulphur compounds released from garlic during aging in water, dilute ethanol or dilute acetic acid. J. Toxicol.14:214.
 
Ledezma E, Apitz-Castro R (2006). Ajoene the main active component of garlic (Allium sativum): a new antifungal agent. Rev Iberoam Micol. 23:75-80.
http://dx.doi.org/10.1016/S1130-1406(06)70017-1
 
Lemar KM, Miguel AA, Sonia C, Brian O, Carsten TM, David L (2007). Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress mediated cell death studied by two-photon microscopy. Yeast. 24(8):695-706.
http://dx.doi.org/10.1002/yea.1503
PMid:17534841 PMCid:PMC2292485
 
Maldonado PD, Chánez-Cárdenas ME, Pedraza-Chaverrí J (2005). Aged garlic extract, garlic powder extract, S-allyl cysteine, diallyl sulfide and diallyl disulfide does not interfere with the antibiotic activity of gentamycin. J. Chromat. A. 19(3):252-254.
 
Mansell P, Reckless J (1991). Effects on serum lipids, blood pressure, coagulation, platelet aggregation and vasodilation. BMJ. 303:379-380.
http://dx.doi.org/10.1136/bmj.303.6799.379
PMid:1912802 PMCid:PMC1670690
 
McMahon FG, Vargas R (1993). Can garlic lower blood pressure? A pilot study, Pharmacotherapy 13:406-407.
PMid:8361870
 
Mirelman D, Motsheit D, Vaton S (1987). Inhibition of growth of Entamoeba histolytica by Allicin, the active principle of garlic extracts (Allium sativum). J. Infect. Dis. 156:243-244.
http://dx.doi.org/10.1093/infdis/156.1.243
PMid:2885381
 
Morihara N, Ushijima M, Kashimoto N, Sumioka I, Nishihama T, Hayama M, Takeda H (2006). Aged garlic extract ameliorates physical fatigue. Biol. Pharm. Bull. 29(5):962-966.
http://dx.doi.org/10.1248/bpb.29.962
PMid:16651727
 
Morioka N, Sze LL, Morton DL, Irie RF (1993). A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunol. Immunother. 37:316-322.
http://dx.doi.org/10.1007/BF01518454
PMid:8402735
 
Nance DM, Luczy-Bachman G, Min P, Chang MS, Amagase H (2006). Effects of aged garlic extract (AGE) on the immunosuppressive effects of stress Brain, Behavior, and Immunity. Isr. Med. Assoc. J. 20(3):50-51.
 
Ohaeri OC (2001). Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabtic rats. Biosci. Rep. 21:19-24
http://dx.doi.org/10.1023/A:1010425932561
 
Onyeagba R, Ugbogu OC, Okeke CU, Iroakasi O (2004). Studies on the antimicrobial effects of garlic (Allium sativum L.), ginger (Zingiber officinale Roscoe) and lime (Citrus aurantifolia L.). Afr. J. Biotechnol. 3:552-554.
 
Parekh J, Chanda S (2007). In vitro antimicrobial activity of Trapa natans L. Fruit rind extracted in different solvents. Afr. J. Biotechnol. 6(6):766-770.
 
Pedrazza-Chaverri J, Tapia E, Medina-Campos ON, de los Angeles Granados M, Franco M (2006). Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis. Life Sci. 62:71-77.
 
Prasad G, Sharma VD, Kumar A (1995). Efficacy of garlic (Allium sativum L.) therapy against experimental dermatophytosis in rabbits. Indian J. Med. Res. 75:465-467.
 
Ratnakar P, Murthy S (1996). Preliminary studies on the antitubercular activity and the mechanism of action of the water extract of garlic (Allium sativum) and its two partially purified proteins (garlic defensis?). Indian J. Clin. Biochem.11 (1):37-41.
http://dx.doi.org/10.1007/BF02868409
 
Shams-Ghahfarokhi M, Shokoohamiri MR, Amirrajab N, Moghadasi B, Ghajari A, Zeini F, Sadeghi G, Razzaghi-Abyaneh M (2006). In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia. 77(4):321-323.
http://dx.doi.org/10.1016/j.fitote.2006.03.014
PMid:16690223
 
Sabayan B, Foroughinia F, Chohedry A (2006). A postulated role of garlic organosulfur compounds in prevention of valproic acid hepatotoxicity. Med. Hypotheses. 68(3):512-514.
http://dx.doi.org/10.1016/j.mehy.2006.07.055
PMid:17046167
 
Sabitha P, Adhikari PM, Shenoy SM (2005). Efficacy of garlic paste in oral candidiasis. Trop Doct. 35(2):99-100.
http://dx.doi.org/10.1258/0049475054037084
PMid:15970035
 
Salman H, Bergman M, Bessler H, Punsky I, Djaldetti M (1999). Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. Int. J. Immunopharmacol. 21:589-597.
http://dx.doi.org/10.1016/S0192-0561(99)00038-7
 
Saw JT, Bahari MB, Ang HH, Lim YH (2006). Potential drug-herb interaction with antiplatelet/anticoagulant drugs. Complement Ther. Clin. Pract. 12(4):236-241.
http://dx.doi.org/10.1016/j.ctcp.2006.06.002
PMid:17030294
 
Sener G, Sehirli AO, Ipci Y, Cetinel S, Cikler E, Gedik N (2005). Chronic nicotine toxicity is prevented by aqueous garlic extract. Plant Foods Hum. Nutr. 60(2):77-86.
http://dx.doi.org/10.1007/s11130-005-5103-x
PMid:16021835
 
Silagy CA, Neil HA (1994). A meta-analysis of the effect of garlic on blood pressure. J. Hypertens. 12:463-468.
http://dx.doi.org/10.1097/00004872-199404000-00017
PMid:8064171
 
Steinmetz KA, Kushi LH, Bostick RM, Folsom AR, Potter JD (1994). Vegetables, fruit, and colon cancer in the Iowa woman's health study. Am. J. Epidemiol. 139:1-15.
PMid:8296768
 
Sumioka I, Hayama M, Shimokawa Y, Shiraishi S, Tokunaga A (2006). Lipid-lowering effect of monascus garlic fermented extract (MGFE) in hyperlipidaemia subjects. Hiroshima. J. Med. Sci. 55(2):59-64.
PMid:16813070
 
Tepe B, Daferera D, Sokmen M, Polissiou M, Sokmen A (2004). In vitro antimicrobial and antioxidant activities of the essential oils and various extracts of thymus. J. Agric. Food Chem. 52:1132-1137.
http://dx.doi.org/10.1021/jf035094l
PMid:14995110
 
Timbo BB, Ross MP, McCarthy PV, Lin CT (2006). Dietary supplements in a national survey: Prevalence of use and reports of adverse events. Am. Diet Assoc.106(12):1966-1974.
http://dx.doi.org/10.1016/j.jada.2006.09.002
PMid:17126626
 
Torok B, Belagyi J, Rietz B, Jacob R (1994). Effectiveness of garlic on the radical activity in radical generating systems. Arzneimittelforschung 44:608-611.
PMid:8024631
 
Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC (1985). Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta Med. 8:460-461.
http://dx.doi.org/10.1055/s-2007-969553
PMid:17342616
 
Tsao SM, Yin MC (2001). In vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oil. J. Med. Microbiol. 50:646-649.
PMid:11444776
 
Wojdylo A, Oszmianski J, Czemerys R (2007). Antioxidant activity and phenolic compounds in 32 selected herbs. Food Chem. 105:940-949.
http://dx.doi.org/10.1016/j.foodchem.2007.04.038
 
Yeh GY, Davis RB, Phillips RS (2006). Use of Complementary Therapies in Patients with Cardiovascular Disease. Am. J. Card. 98(5):673-680.
http://dx.doi.org/10.1016/j.amjcard.2006.03.051
PMid:16923460
 
Yin J, Li H (2007). Anaphylaxis Caused by Younger Garlic. J. Allergy Clin. Immunol. 119 (1):34.
http://dx.doi.org/10.1016/j.jaci.2006.11.151

 


APA (2013). Medicinal values of garlic: A review. International Journal of Medicine and Medical Sciences, 5(9), 401-408.
Chicago Gebreselema Gebreyohannes and Mebrahtu Gebreyohannes. "Medicinal values of garlic: A review." International Journal of Medicine and Medical Sciences 5, no. 9 (2013): 401-408.
MLA Gebreselema Gebreyohannes and Mebrahtu Gebreyohannes. "Medicinal values of garlic: A review." International Journal of Medicine and Medical Sciences 5.9 (2013): 401-408.
   
DOI 10.5897/IJMMS2013.0960
URL http://academicjournals.org/journal/IJMMS/article-abstract/4438B2713

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