International Journal of Medicine and Medical Sciences
Subscribe to IJMMS
Full Name*
Email Address*

Article Number - 69A182B64162


Vol.9(5), pp. 47-50 , May 2017
DOI: 10.5897/IJMMS2016.1275
ISSN: 2006-9723



Full Length Research Paper

Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria



Emmanuel Asuquo Etim
  • Emmanuel Asuquo Etim
  • Laboratory Department, Federal Medical Centre, Yola, Adamawa State, Nigeria
  • Google Scholar
Mathias Abiodun Emokpae
  • Mathias Abiodun Emokpae
  • Department of Medical Laboratory Science, University of Benin, Benin City, Nigeria
  • Google Scholar
Jessy Thomas Medugu
  • Jessy Thomas Medugu
  • Department of Medical Laboratory Science, University of Maiduguri, Borno State, Nigeria
  • Google Scholar
Isaac Ferdinard Medugu
  • Isaac Ferdinard Medugu
  • Dialysis Centre, Federal Medical Centre, Yola, Adamawa State, Nigeria
  • Google Scholar







 Received: 29 October 2016  Accepted: 28 November 2016  Published: 31 May 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Low lymphocyte count in end stage renal disease (ESRD) patients receiving maintenance hemodialysis was documented. This study aims to correlate the levels of lymphocyte count with serum calcium level, and neutrophil-to-lymphocyte ratio (NLR) in ESRD patient receiving hemodialysis in Northeast Nigeria. Seventy eight (78) patients receiving hemodialysis and 75 clinically healthy subjects (control) participated in the present study. Full blood count and serum calcium level were determined by using a Sysmex XP-300 Hematology Analyzer and a Selectra Pro-S Chemistry Analyzer, respectively. The mean levels of lymphocyte count, packed cell volume, hemoglobin and serum calcium level were significantly lower (p<0.001), while neutrophil, and NLR values were significantly higher (p<0.001) in ESRD patients undergoing hemodialysis as compared to the healthy control subjects. Lymphocyte count was negatively correlated with NLR value (r=-0.341; 0.05) but positively with serum calcium (r=0.904; p<0.001). In end stage renal disease (ESRD) patient receiving hemodialysis, lymphocyte count was negatively correlated with NLR value and positively with serum calcium level.

 

Key words: Lymphocyte count, serum calcium level, neutrophil to lymphocyte ratio (NLR), hemodialysis.

Azab B, Bhatt V, Phookan J(2012). Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann. Surg. Oncol. 19(1):217-224.
Crossref

 

Binnetoğlu E, Şengül E, Halhallı G, Dindar S, Şen H (2014). Is neutrophil lymphocyte ratio an indicator for proteinuria in chronic kidney disease? J. Clin. Lab. Anal. 28(6):487-492.
Crossref

 
 

Block GA, Klassen PS, Lazarus JM, Ofsthum N, Lowrie EG, Chertow GM (2004). Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J. Am. Soc. Nephrol.15:2208-2218.
Crossref

 
 

Donato D, Dimitrios D, Nicholas C, Jana R, Karel R(1992). Effects of Hemodialysis on Activation of Lymphocytes: Analysis by an In Vitro Dialysis Model. J. Am. Soc. Nephrol. 2:1490-1497.

 
 

Egbi OG, Okafor UH, Miebodei KE, Kasia BE, Kunle-Olowu OE, Unuigbe EI (2014). Prevalence and correlates of chronic kidney disease among civil servants in Bayelsa state, Nigeria. Niger. J. Clin. Pract. 17:602-607.
Crossref

 
 

Fung F, Sherrard DJ, Gillen DL (2002). Increased risk for cardiovascular mortality among malnourished end-stage renal disease patients. Am. J. Kidney Dis. 40:307-314.
Crossref

 
 

Hatice S, Lale S, Mehmet S, Orhan M, Ahmet T (2012). The relation between differential leukocyte count, neutrophil to lymphocyte ratio and the presence and severity of coronary artery disease. J. Int. Med. 2:163-169.

 
 

Johnson DW, Wiggins KJ, Armstrong KA (2005). Elevated white cell count at commencement of peritoneal dialysis predicts overall and cardiac mortality. J. Kidney Int. 67:738-743.
Crossref

 
 

Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, Yuzawa Y (2012). Aspects of immune dysfunction in end-stage renal disease. Clin. J. Am. Soc. Nephrol. 3(5):1526-1533.
Crossref

 
 

Keizman D, Gottfried M, andIsh-Shalom M (2012). Pretreatment neutrophil-to-lymphocyte ratio in metastatic castration-resistant prostate cancer patients treated with ketoconazole: association with outcome and predictive nomogram. J. Oncol. 17(12):1508-1514.
Crossref

 
 

Kultigin T, Faith M, Fatih O, Adalet O, Emin M, Aysu O (2013). Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. J. Hemodial. Int. 17(3)391-396.
Crossref

 
 

Kuwae N, Kopple JD, Kalantar-Zadeh K (2005). A low lymphocyte percentage is a predictor of mortality and hospitalization in hemodialysis patients. .J. Clin. Nephrol. 63(1):22-34.
Crossref

 
 

Lavin-Gomez BA, Palor-Fontanet R, Gago-Fraile M, Quintanar-Lartundo JA, Gomez-Palomo E, Gonzalez-Lamuno D. (2011). Inflammation Markers, Chronic Kidney Disease, and Renal Replacement Therapy. J. Advperit. Dial. 27:33-37.

 
 

Manal AE, Shaimaa AP (2015). Peripheral Blood Lymphocyte Subsets count in Children on Regular Hemodialysis. Int. J. immunol. 3(1):1-6. Memoli B, Postiglion L, Cianciaruso B (2000). Role of different dialysis memebrane in the release of interleukin-6 soluble receptor in uremic patients. J. Kidney Int. 58:417-424.

 
 

Okyay G, Inal S, Oneç K, Er E, Paşaoğlu O, Paşaoğlu H (2013). Neutrophil to lymphocyte ratio in evaluation of inflammation in patients with chronic kidney disease. Renal Failure 35(1):29-36.
Crossref

 
 

Panichi V, Tetta C, Rindi P, Palla R, Lonnermann G (1998).Plasma C-reactive protein is linked to back filtration associated interleukin-6 production. Am. J. Nephrol. 44:415-417.

 
 

Pecoits-Filho R, Barany P, Lindholm B, Heimburger O, Stenvinkel P (2002). Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. J. Nephro. Dial. Transplant. 17:1684-1688.
Crossref

 
 

Petrie HT, Klassen LW, Kay HD (2007). Inhibition of human cytotoxic T lymphocyte activity in vitro by autologous peripheral blood granulocytes. J. Immunol. 134(1):230-234.

 
 

Reddan DN, Klassen PS, Szczech LA (2003). White blood cells as a novel mortality predictor in hemodialysis patients. J. Nephrol. Dial. Transpl. 18:1167-1173.
Crossref

 
 

Roberto P, Bengt L, Jonas A, Peter S (2003). Update on interleukin and its role in chronic renal failure. J. Nephrol. Dial. Transpl. 18(6):1042-1045.
Crossref

 
 

Sakato K, Tomoko A, Bengt L, Shoichi M (2015). Neutrophile/lymphocyte ratio: A promising Prognostic Marker in patient with chronic Kidney disease. J. Inflamm. Cell Signal 2:683-685.

 
 

Templeton AJ, McNamara MG, Šeruga B (2014). Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J. Natl. Cancer Inst. 106(6):145-149.
Crossref

 
 

Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ (2012). The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. J. Renal Fail. 34:155-159.
Crossref

 

 


APA Etim, E. A., Emokpae, M. A., Medugu, J. T., & Medugu, I. F. (2017). Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria. International Journal of Medicine and Medical Sciences, 9(5), 47-50.
Chicago Emmanuel Asuquo Etim, Mathias Abiodun Emokpae, Jessy Thomas Medugu and Isaac Ferdinard Medugu. "Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria." International Journal of Medicine and Medical Sciences 9, no. 5 (2017): 47-50.
MLA Emmanuel Asuquo Etim, et al. "Correlation of lymphocyte count with serum calcium level and neutrophil-to-lymphocyte ratio in end stage renal disease patients undergoing hemodialysis in Adamawa State, Nigeria." International Journal of Medicine and Medical Sciences 9.5 (2017): 47-50.
   
DOI 10.5897/IJMMS2016.1275
URL http://academicjournals.org/journal/IJMMS/article-abstract/69A182B64162

Subscription Form