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Article Number - 8B0BF4B11

Vol.5(9), pp. 391-395 , September 2013
ISSN: 2006-9723

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Effect of maternal iron status on placenta, fetus and newborn

K. N. Agarwal
  • K. N. Agarwal
  • Indian National Science Academy & Present health Care & Research Association, D-115, Sector -36, NOIDA, Gautam Budha Nagar-201301, India.
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V. Gupta
  • V. Gupta
  • Anderson Cancer Center, Houstan Tx, USA.
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S. Agarwal
  • S. Agarwal
  • Reader Pediatrics Institute Medical Sciences, Varanasi, India.
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 Accepted: 19 June 2013  Published: 11 September 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Maternal anemia (hypoferriemia) results in increased pre-term and low birth weight deliveries and higher rate of stillbirths. There are irreversible structural alterations in placenta. The transfer of iron to fetus is reduced in spite of gradient in relation to severity of maternal hypoferriemia. The fetal hepatic and brain iron contents were reduced. The brain iron reduction was irreversible on rehabilitation and was associated with irreversible neurotransmitter and their receptor alterations.


Key words: Maternal anemia, stillbirths, placenta.


AgarwalK N, Krishna M, Khanna S (1981). Placental morphological and biochemical studies in maternal anemia before and after treatment. J. Trop. Paediatr. 27:162–165.
Agarwal KN (1991). Functional consequences of nutritional anemia. Proc. Nutr. Soc. India 37:127-132.
Agarwal DK, Upadhyay SK, Agarwal KN, Singh RD, Tripathi AM (1989). Anaemia and mental functions in rural primary school children. Ann. Trop. Paediatr. 9:194-198.
Agarwal KN (2001). Iron and the brain: neurotransmitter receptors and magnetic resonance spectroscopy. Br. J. Nutr. 85:Suppl 2 S147-S150.
Agarwal S, Agarwal A Bansal A (2002). Birth weight patterns in rural undernourished pregnant women. Indian Pediatr. 39:244-253.
Agarwal KN (1984). The effects of maternal iron deficiency on placenta and foetus. In advances in international maternal child health. Vol 4 Editors Jelliffe D B & Jelliffe F E P Clarendon Press Oxford pp. 26-35.
Agarwal KN Agarwal DK Sharma A, Sharma K, Prasad K, Kalita MC, Khetarpaul N, Kapoor AC, Vijayalekshmi L, Govilla AK, Panda SM, Kumari P (2006). Prevalence of anemia in pregnant and lactating women in India. Indian J. Med. Res. 124:173-184.
Agarwal KN, Agarwal DK, Mishra KP (1991). Impact of anemia prophylaxis in pregnancy on maternal hemoglobin, serum ferritin and birth weight. Indian J. Med. Res. 94:277-280.
Agarwal RMD, Tripathi AM, Agarwal KN (1983). Cord blood hemoglobin iron and ferritin status in maternal anemia. Acta Paediatr. Scand. 72:545-548.
Agboola A (1975). Placental changes in patients with a low haematocrit. Br. J. Obstet. Gynaecol. 82:225-227.
Beischer NA, Sivasamboo R, Vohra S, Silpisornkosal S, Reid S (1970). Placental hypertrophy in severe pregnancy anemia. J. obstet. Gynaecol. Br Cwlth 77:398-409.
Bhatia VP, Katiyar GP, Agarwal KN (1979). Effect of intrauterine nutritional deprivation on neuromotor behaviour of the newborn. Acta Paediatr. Scand. 68:561-566.
Bhatia VP, Katiyar GP, Agarwal KN, Das TK, Dey PK (1980). Sleep cycle studies in babies of undernourished mothers. Arch. Dis. Child. 55:134-138.
PMid:7377832 PMCid:PMC1626671
Emamghorashi F, Heidari T (2004). Iron status of babies born to iron-deficient anemic mothers in an Iranian hospital. East Mediterr Health J. 10:808-814.
Fletcher J Suter PEN (1969). The transport of iron by the human placenta. Clin. Sci. 36:209-220.
Fox H (1967). The incidence and significance of vasculo-syncytial membrane in the human placenta. J. Obstet. Gynaecol. Br. Cwlth. 74:28-33.
Franson GN, Agarwal KN, Mehdin GM, Hambraeus L (1985). Increased breast milk iron in severe maternal anemia: Physiological trapping or leakage. Acta Paediatr. Scand. 74:290-291.
Gomber S, Agarwal KN, Mahajan C, Agarwal N (2002). Impact of daily versus weekly hematinic supplementation on anemia in pregnant women. Indian Pediatr. 39:339-346.
Indian Council Medical Research (1989). Evaluation of the national nutritional anemia prophylaxis programme. ICMR report, New Delhi.
Indian Council Medical Research (1992) Field supplementation trial in pregnant women with 60, 120 and 180 mg of iron and 500 ug of folic acid. ICMR report, New Delhi.
Khanna S, Chand S, Singla PN, Agarwal KN (1979). Morphological study of placenta in pregnancy anemia. Indian J. Pathol. Microbiol. 22:7-12.
Khurana V, Agarwal KN, Gupta S, Nath T (1970). Estimation of total protein and iron content in breast milk of Indian lactating mothers. Indian Pediatr. 7:659-665.
Kumar A, Rai AK, Basu S, Dash D, Singh JS (2008). Cord blood and breast milk iron status in maternal anemia. Pediatrics 121: 673-677.
Lee HS, Kim MS, Kim MH, Kim YJ, Kim WY (2006). Iron status and its association with pregnancy outcome in Korean pregnant women. Eur. J. Clin. Nutr. 60:1130-1135.
Marwah P, Singla PN, Krishna M, Agarwal KN (1979). Effect of pregnancy anemia on cellular growth in the human placenta. Acta Paediatr. Scand. 68:899-901.
McCann JC, Ames BN (2007). An overview of evidence for a causal relation between iron deficiency during development and deficit in cognitive or behavioral function. Am. J. Clin. Nutr. 85:931- 945.
Mittal RD, Pandey A, Mittal B, Agarwal KN (2002). Effect of latent iron deficiency on GABA and glutamate receptors. Indian J. Clin. Biochem. 17:1-6.
PMid:23105345 PMCid:PMC3454128
Nair GTR, Agarwal KN, Kotwani BG (1970). Nutritional deficiency anemia in later months of pregnancy. J. Obstet. Gynecol. India 20:594-601.
NFHS-2 &- 3 India 1998-99-& 2005 National family Health Survey-2&3 Anemia among women and children. Mumbai: International Institute for Population Sciences; 2000.
Paiva Ade A, Rondo PH, Paqliusi RA, Latorre Mdo R, Cardoso MA, Gondim SS (2007). Ralationship between the iron status of pregnant women and their newborns. Rev Saude Publica 41:321-327
Prasad C, Devi R, Agarwal KN (1979). Effect of dietary proteins on fetal brain protein and glutamic acid metabolism in rats. Neuochem. 32:1309-1314.
Prasad C, Agarwal KN (1980). Intrauterine malnutrition and the brain. Effect of enzymes and free amino acids related to glutamate metabolism. J. Neurochem. 34:1270-1273.
Rios E, Lipschitz DA, Cook JD, Smith NJ (1975). Relationship of maternal and infant iron stores as assessed by determination of plasma ferritin. Pediatrics 55:694-699.
Ratten GJ, Beischer NA (1972). Significance of anemia in an obstetric population in Australia. J. Obstet. Gynaecol. Br. Cwlth 79:228-37.
Sen S, Agarwal KN (1976). Placental protein, free alpha amino nitrogen and nucleic acids in maternal undernutrition. Indian Pediatr. 13:907-13.
Sharma A Agarwal KN (2007). Author's reply. Indian J. Med. Res. 125:101.
Shukla A, Agarwal KN, Shukla GS (1989). Latent iron deficiency alters gamma-amino butyric acid and glutamate metabolism in rat brain. Experentia 45:343-345.
Shukla A, Agarwal KN, Chansuria JPN, Taneja V (1989). Effect of latent iron deficiency on 5-hydroxytryptamine metabolism in rat brain. J. Neurochem. 52:730-735.
Shukla A, Agarwal KN, Shukla GS (1989). Studies on brain catecholamine metabolism following latent iron deficiency and subsequent rehabilitation in rat. Nutr. Res. 9:1177-1186.
Shukla A, Agarwal KN, Shukla GS (1989). Effect of latent iron deficiency on metal levels of rat brain regions. Biol. Trace Elem. Res. 22:141-152.
Singla PN, Gupta VK, Agarwal KN (1985). Storage iron in human fetal organs. Acta Paediatr. Scand. 74:701–706.
Singla PN, Chand S, Agarwal KN (1979). Cord serum and placental tissue iron status in maternal hypoferreimia. Am. J. Clin. Nutr. 32:1462-1465.
Singla PN, Chand S, Khanna S, Agarwal KN (1978). Effect of maternal anemia on the placenta and the newborn. Acta Paediatr Scand 67:645-648.
Taneja V, Mishra KP, Agarwal KN (1986). Effect of maternal iron deficiency on GABA shunt pathway of developing rat brain. Indian J. Expt. Biol. 28:466-469.
Taneja V, Mishra KP, Agarwal KN (1986). Effect of early iron deficiency in rat on the gamma-amino butyric acid shunt in brain. J. Neurochem. 46:1670-1674.
Teoteja G, Singh P (2001). Micronutrient deficiency disorders in 16 districts of India. Report of an ICMR Task Force Study – District Nutrition Project. Part 1.
Vahlquist BC (1941). Das serumerrisen, eine paediatrisch kinische und experimental studies. Acta Paeditr (Suppl 6); 28:1-4.
Walter E (2003). Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood. Full. Nutr. Bull. 24:(4 Suppl) S104-110.


APA (2013). Effect of maternal iron status on placenta, fetus and newborn. International Journal of Medicine and Medical Sciences, 5(9), 391-395.
Chicago K. N. Agarwal, V. Gupta and S. Agarwal. "Effect of maternal iron status on placenta, fetus and newborn." International Journal of Medicine and Medical Sciences 5, no. 9 (2013): 391-395.
MLA K. N. Agarwal, V. Gupta and S. Agarwal. "Effect of maternal iron status on placenta, fetus and newborn." International Journal of Medicine and Medical Sciences 5.9 (2013): 391-395.

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