Journal of AIDS and HIV Research
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Article Number - 562428164344


Vol.9(6), pp. 123-128 , June 2017
DOI: 10.5897/JAHR2017.0422
ISSN: 2141-2359



Full Length Research Paper

Human immunodeficiency virus and hepatitis B virus (HIV/HBV) co-infection in people living with HIV/AIDs identified in Yaoundé Central Hospital, Cameroon: Seroprevalence and impact on the disease progression



Djuidje Ngounoue Marceline
  • Djuidje Ngounoue Marceline
  • Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
  • Google Scholar
Ambassa Axel Cyriaque
  • Ambassa Axel Cyriaque
  • Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
  • Google Scholar
Guiateu Tamo Ida Marlene
  • Guiateu Tamo Ida Marlene
  • Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
  • Google Scholar
Moundipa Fewou Paul
  • Moundipa Fewou Paul
  • Department of Biochemistry, Faculty of Science, University of Yaoundé I, Cameroon.
  • Google Scholar







 Received: 08 March 2017  Accepted: 10 April 2017  Published: 30 June 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Co-infection with HIV and hepatitis B virus (HBV) has become an important factor of co-morbidity and mortality. The aim of this study was to determine the seroprevalence of HIV/HBV co-infection and its effect on the disease progression in people living with HIV/AIDS identified in Yaoundé Central Hospital. Blood samples from 75 HIV positive patients were collected in Yaoundé Central Hospital from November 2015 to February 2016, for the determination of hepatitis B virus surface antigen (HBsAg) using immunoassays. Cluster of differentiation 4 (CD4) T-cells count and biochemical markers of liver function were also collected and analyzed. The socio-demographic data were also collected. The effect sizes were confirmed using G*Power version 3.1.9.2 software. The data were entered and analyzed using the SPSS Version 22.1 software.  The statistical tests performed were x2, and Pearson correlation, with significant difference at the threshold p ≤ 0.05. Hepatitis B virus surface antigen (HBsAg) was identified in 12 patients out of 75 HIV-positive patients, for a HIV/HBV co-infection prevalence of 16%. The co-infection rate was higher in women 9 (12%) than in men 3 (4%). Among HIV infected patients, a negative and significant correlation was observed between CD4 count and ALT activity, and between the concentration of conjugated bilirubin and the activity of alkaline phosphatase (ALP) p≤ 0.05. The prevalence of HIV/HBV co-infection is higher among HIV positive patients in the Yaoundé Central Hospital. HIV associated with HBV plays a role in the disease progression. Consequently, it is important that a national management programme is in place in the country to monitor the incidence and morbidity rates of these affections.

 

Key words: Co-infection, seroprevalence, hepatitis B virus (HBV), human immunodeficiency virus (HIV), Cluster of differentiation 4 (CD4) T-cells, liver enzymes, disease progression.

Dieterich DT (2007).Special considerations and treatment of patients with HBV-HIV coinfection. Antivir. Ther. 12:H43-H51.

 

Faul F, Erdfelder E, Buchner A, Lang AG (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behav. Res. Methods 41:1149-1160.
Crossref

 
 

Faul F, Erdfelder E, Lang, AG, Buchner A (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 39:175-191.
Crossref

 
 

Gita R, Brodie D (2013).Women and HIV in Sub-Saharan Africa. AIDS Res. Ther. 10:30.
Crossref

 
 

Jobarteh M, Marine M, Ingrid P, Adam J, Ramu SN, Abraham A, Kevin P, Matt C, Andrew A, Sarah R-J, Hilton W, Richard T, Assan J, Maïmouna M (2010). Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians. Virol J. 7:230.
Crossref

 
 

Laurent C, Bourgeois A, Mpoudi-N E, Kouanfack C, Ciaffi L, Nkoue N (2010). High rates of active hepatitis B and C co-infections in HIV-1 infected Cameroonian adults initiating antiretroviral therapy. British HIV Ass. HIV Med. 11:85-89.
Crossref

 
 

Mabala R (2006). From HIV prevention to protection: addressing the vulnerability of girls and young women in urban areas. Environ. Urban 18 (2):407-432.
Crossref

 
 

Nagu TJ, Bakari M, Matee M (2008). Hepatitis A, B and C viral co-infections among HIV-infected adults presenting for care and treatment at Muhimbili National Hospital in Dar es Salaam, Tanzania. BMC Public Health 8:416.
Crossref

 
 

National Institute of Statistics (2011). Cameroon Demographic and Health Survey and Multiple Indicators Cluster Survey DHS-MICS. HIV prevalence and associated factors. pp. 265-285.

 
 

Noah ND, Njouom R, Bonny A, Pirsou P, Meli J, Biwole Sida M (2011). HBs antigen prevalence in blood donors and the risk of transfusion of hepatitis B at the Central hospital of Yaoundé, Cameroun. Open J. Gastroenterol. 1(02):23.
Crossref

 
 

Nyirenda M, Beadsworth M, Stephany P, Hart C, Hart I, Munthali C (2008). Prevalence of infection with hepatitis B and C virus and co-infection with HIV in medical inpatients in Malawi. J. Infect. Dis. 57:72-77.

 
 

Obi SO, Baba HA, Baba MM, Amilo GI, Bukar A (2012). The Effect of Co-infection of HIV and Hepatotropic Viruses on Selected Biochemical and Haematological Markers of Patients in Northeastern Nigeria. Int. J. Trop. Dis. Health 4:568-581.
Crossref

 
 

Ochola E, Ocama P, Orach CG (2013). High burden of hepatitis B infection in Northen Uganda: Results of a population-based survey. BMC Public Health 13(1):727.
Crossref

 
 

Odenyo H, Schoub B, Ally R, Kairu S, Segal I (2000). Hepatitis B and C virus infections and liver function in AIDS patients at Chrishanibaragwanath hospital Johannesburg. East Afr. Med. 77(1):13-15.

 
 

Olufemi A, Emmanuel A, Zaccheus A, Ibrahim W, Funmilayo E, Patience A (2009). Hepatitis B and C virus co-infection in Nigerian patients with HIV infection. J. Infect. Dev. Ctries. 3(5):369-375.

 
 

Pratt DS, Kaplan MM (2000). Evaluation of abnormal liver enzyme results in asymptomatic patients. New England J. Med. 342:1266-711.
Crossref

 
 

The Joint United Nations Programme on HIV and AIDS (UNAIDS) (2016). Global AIDS Update 2016.

 
 

The Joint United Nations Programme on HIV and AIDS (UNAIDS) (2016). Fact Sheet 2016.

 
 

WHO (World Health Organization) (2013). Global policy report on the prevention and control of viral hepatitis in WHO Member States 2013: ISBN 978 92 4 156463 2.

 
 

WHO (World Health Organization) (2016). HIV and hepatitis coinfections: Available at: 

View

 
 

Yohannes Z, Wondemagegn M, Mulat Yimer, Bayeh A (2014). Seroprevalenceand risk factors of hepatitis B virus and human immunodeficiency virus infection among pregnant women in Bahir Dar city, Nortwest Ethiopia: a cross sectional study. BMC Infect. Dis. 14:118.
Crossref

 
 

Zhou J, Dore GJ, Zhang F, Lim PL, Chen YM (2007). TREAT Asia HIV Observational Database. Hepatitis B and C virus co-infection in The TREAT Asia HIV Observational Database. J. Gastroenterol Hepatol. 22:1510-1518.
Crossref

 
 

Zoufaly A, Onyoh EF, Tih PM, Awasom CN, Feldt T (2012). High prevalence of hepatitis B and syphilis co-infections among HIV patients initiating antiretroviral therapy in the north-west region of Cameroon. Int. J. STD AIDS. 23:435-438.
Crossref

 

 


APA Marceline, D. N., Cyriaque, A. A., Marlene, G. T. I., & Paul, M. F. (2017). Human immunodeficiency virus and hepatitis B virus (HIV/HBV) co-infection in people living with HIV/AIDs identified in Yaoundé Central Hospital, Cameroon: Seroprevalence and impact on the disease progression. Journal of AIDS and HIV Research, 9(6), 123-128.
Chicago Djuidje Ngounoue Marceline, Ambassa Axel Cyriaque, Guiateu Tamo Ida Marlene and Moundipa Fewou Paul. "Human immunodeficiency virus and hepatitis B virus (HIV/HBV) co-infection in people living with HIV/AIDs identified in Yaoundé Central Hospital, Cameroon: Seroprevalence and impact on the disease progression." Journal of AIDS and HIV Research 9, no. 6 (2017): 123-128.
MLA Djuidje Ngounoue Marceline, et al. "Human immunodeficiency virus and hepatitis B virus (HIV/HBV) co-infection in people living with HIV/AIDs identified in Yaoundé Central Hospital, Cameroon: Seroprevalence and impact on the disease progression." Journal of AIDS and HIV Research 9.6 (2017): 123-128.
   
DOI 10.5897/JAHR2017.0422
URL http://academicjournals.org/journal/JAHR/article-abstract/562428164344

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