Journal of Biophysics and Structural Biology
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Article Number - 5E917DE10946


Vol.5(1), pp. 1-9 , July 2013
DOI: 10.5897/JBSB11.002
ISSN: 2141-2200



Full Length Research Paper

Epigenetic regulation of PGC1 α in human type 2 diabetes


Y. Dhanusha Yesudhas




Department of Bioinformatics, Karunya University, Coimbatore India.


Email: dhanusha2504@gmail.com






 Accepted: 15 November 2012  Published: 31 July 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Type 2 diabetes mellitus (T2DM) is the most common metabolic disease in theworld, reaching epidemic proportions. PPARGC1A mRNA expression is reduced in islets from patients with diabetes 2 and it is influenced by both genetic and epigenetic factor. The epigenetic modification, results as a two fold increase in DNA methylation of the PGC1A promoter of diabetes. This two fold increase in DNA methylation is due to the DNA methyl transferase1 (DNMT1) enzyme. In the present study, methylation activity of DNMT 1 enzyme was inhibited with suitable methylation inhibitors which led to the decrease of the hypermethylation of PGC 1 alpha protein. The interaction study of this modified DNMT1 with PGC 1 alpha leads to the new way of drug discovery in type 2 diabetes.

 

Key words: Type 2 diabetes mellitus (T2DM), methyl transferase1 (DNMT1), epigenetic modification.

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APA (2013). Epigenetic regulation of PGC1 α in human type 2 diabetes. Journal of Biophysics and Structural Biology, 5(1), 1-9.
Chicago Y. Dhanusha Yesudhas. "Epigenetic regulation of PGC1 α in human type 2 diabetes." Journal of Biophysics and Structural Biology 5, no. 1 (2013): 1-9.
MLA Y. Dhanusha Yesudhas. "Epigenetic regulation of PGC1 α in human type 2 diabetes." Journal of Biophysics and Structural Biology 5.1 (2013): 1-9.
   
DOI 10.5897/JBSB11.002
URL http://academicjournals.org/journal/JBSB/article-abstract/5E917DE10946

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