Journal of Cell Biology and Genetics
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Article Number - 5BD7ADB53698

Vol.5(1), pp. 1-9 , June 2015
DOI: 10.5897/JCBG2014.0036
ISSN: 2141-6516

Full Length Research Paper

Pancreatic response after treatment with 1,5-Bis(3,5- dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in rats

Nofa, A.E.*
  • Nofa, A.E.*
  • Department of Zoology, Faculty of Science, Menoufia University, Egypt.
  • Google Scholar
Lampatov, V.V.
  • Lampatov, V.V.
  • Department of Pharmacology, Altai State Medical University, Barnaul, Russia.
  • Google Scholar
Lepilov, A.V.
  • Lepilov, A.V.
  • Department of Pathological Anatomy, Altai State Medical University, Barnaul, Russia.
  • Google Scholar

 Received: 18 January 2014  Accepted: 12 June 2015  Published: 30 June 2015

Copyright © 2015 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0

3,5-Dimethylpyrazole (U-6245) is a hypoglycemic and antilipolytic agent used in the treatment of diabetes mellitus. Complex 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper was prepared in 2009. This study indicated that 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3- oxapentane-diacetatocopper has hypoglycemic properties by decreasing glucose level in blood but caused histopathological changes in the pancreas rats. Rats treated with 1,5-Bis(3,5-dimethylpyrazol-1- yl)-3-oxapentane diacetatocopper for 2, 4 and 6 weeks revealed inflammatory infiltration in the pancreas, marked cytoplasmic vacuoles, congestion of blood vessels with edema and haemorrhage, as well as, some of the degenerated cells showed necrosis. Large spaces were detected in some areas due to degeneration of cells. Sera of animals treated with 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in the present study revealed a significant decrease in serum glucose after 2, 4 and 6 weeks of treatment.

Key words: Hypoglycemic agent, glucose, pancreas, necrosis.

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APA Nofa, A. E.*, Lampatov, V. V. & Lepilov, A. V. (2015). Pancreatic response after treatment with 1,5-Bis(3,5- dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in rats. Journal of Cell Biology and Genetics, 5(1), 1-9.
Chicago Nofa, A.E., Lampatov, V.V. and Lepilov, A.V.. "Pancreatic response after treatment with 1,5-Bis(3,5- dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in rats." Journal of Cell Biology and Genetics 5, no. 1 (2015): 1-9.
MLA Nofa, et al. "Pancreatic response after treatment with 1,5-Bis(3,5- dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in rats." Journal of Cell Biology and Genetics 5.1 (2015): 1-9.
DOI 10.5897/JCBG2014.0036

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