Journal of Cell Biology and Genetics
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Article Number - 654591F939


Vol.2(1), pp. 8 - 11 , March 2011

ISSN: 2141-6516



Full Length Research Paper

Molecular characterization of fusion transcripts in prostate cancer patients: A tool having diagnostic implications in Pakistan



Ammad A. Farooqi
  • Ammad A. Farooqi
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
  • Google Scholar
Sundas Fayyaz
  • Sundas Fayyaz
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
  • Google Scholar
Zeeshan Javed
  • Zeeshan Javed
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
  • Google Scholar
Asma M. Riaz
  • Asma M. Riaz
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
  • Google Scholar
Shahzad Bhatti
  • Shahzad Bhatti
  • Institute of Molecular Biology and Biotechnology, University of Lahore, Pakistan.
  • Google Scholar







 Accepted: 15 March 2011  Published: 31 March 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Substantial fraction of information has been added with reference to fusion transcripts in hematological malignancies. However these fusion transcripts have been characterized in epithelial cells of prostate and are documented to gear up the process of neoplasia. TMPRSS2-ERG and related transcripts are key offenders in the subversion of core biological systems driving oncogenic transformation. In an RT PCR based study, 90 samples of tissue specimen of prostate cancer patients and 20 “prostate cancer negative” tissue specimens from different hospitals of Lahore and Islamabad were analyzed. There was a prevalence of atleast one isoform in 65 patients. There is no pre-existing accurate and precise assay to determine or evaluate the aggressiveness of prostate cancer in Pakistan. This study underscores that prostate cancer tissue specimen harbor hormonally regulated TMPRSS2-ERG and NDRG1-ERG fusions. This study represents a different approach in the clinical management of prostate cancer in Pakistan. It has to be included in diagnosis and prognosis to improve the treatment of prostate cancer. It seems pragmatic that PSA based evaluations do not guarantee a proper and scrutinized analysis of prostate cancer patients.

 

Key words: Fusion transcript, prostate cancer, gene, RNA.

 


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APA (2011). Molecular characterization of fusion transcripts in prostate cancer patients: A tool having diagnostic implications in Pakistan. Journal of Cell Biology and Genetics, 2(1), 8 - 11.
Chicago Ammad A. Farooqi, Sundas Fayyaz, Zeeshan Javed, Asma M. Riaz, and Shahzad Bhatti. "Molecular characterization of fusion transcripts in prostate cancer patients: A tool having diagnostic implications in Pakistan." Journal of Cell Biology and Genetics 2, no. 1 (2011): 8 - 11.
MLA Ammad A. Farooqi, et al. "Molecular characterization of fusion transcripts in prostate cancer patients: A tool having diagnostic implications in Pakistan." Journal of Cell Biology and Genetics 2.1 (2011): 8 - 11.
   
DOI
URL http://academicjournals.org/journal/JCBG/article-abstract/654591F939

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