Journal of Cell Biology and Genetics
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Article Number - 6BA497E49112


Vol.4(4), pp. 40-52 , December 2014
DOI: 10.5897/JCBG2014.0039
ISSN: 2141-6516



Review

Basic biology and therapeutic application of stem cells in various human and animal diseases



Teshager Dubie*
  • Teshager Dubie*
  • College of Veterinary Medicine and Agriculture, Addis Ababa University, P.O. Box 34, Debre Zeit, Ethiopia.
  • Google Scholar
Berhanu Admassu
  • Berhanu Admassu
  • Feinstein International Center, Tufts University, Boston, UAS, Senior policy advisor, P.O. Box 1078, Addis Ababa, Ethiopia.
  • Google Scholar
Tesfaye Sisay
  • Tesfaye Sisay
  • Institute of Biotechnology, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
  • Google Scholar
Hailemaryam Shiferaw
  • Hailemaryam Shiferaw
  • College of Medicine and Health Science, Wollo University, P. O. Box 1145, Wollo Dessie, Ethiopia.
  • Google Scholar







 Received: 18 November 2014  Accepted: 03 December 2014  Published: 31 December 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Stem cells are a population of precursor cells that are capable of developing into many different cell types in the body. They are unspecialized cells that can give rise to specialized cells and capable of dividing and renewing themselves for long periods. Based on the potency, stem cells can be totipotent, pluripotent, multipotent, oligopotent, unipotent and based on source it can be divided as embryonic, fetal, adult, amniotic fluid, cord blood, and induced pluripotent stem cells. Stem cell microenvironment (niche) providing support and stimuli to control stem cell properties. The application of stem cells in human medicine is well established and it is commonly used for chronic and accidental injuries and in veterinary medicine they rapidly become a visible tool for regenerative therapy of chronic, debilitating and various unresponsive clinical diseases and disorders. Unquestionably, the development of bioprocess technologies for the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic as therapeutics necessitates the application of engineering principles and practices to achieve control, reproducibility, automation, validation and safety of the process and the product. A stem cell therapy is a treatment that uses stem cells, or cells that come from stem cells, to replace or to repair a patient’s cells or tissues that are damaged. Stem cells undoubtedly offer tremendous potential to treat many human and animal diseases and to repair tissue damage resulting from injury. Although stem cell holds pivotal promise in treatments of many incurable diseases, it has many critical limitations.

 

Key words: Application, biology, bioprocess, limitation, niche, stem cells. 

Arias A (2008). Drosophila melanogaster and the development of biology in the 20th century. Methods Mol. Biol. 420: 1–25.
Crossref
 
Carvalho Ade M, Badial PR, Álvarez LE, Yamada AL, Borges AS, Deffune E, Hussni CA, Garcia Alves AL. (2013). Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial. Stem Cell Res. Ther. 4: 85.
Crossref
 
Bigham-Sadegh A, Mirshokraei P, Karimi I, Oryan A, Aparviz A, Shafiei-Sarvestani Z (2012). Effects of adipose tissue stem cell concurrent with greater omentum on experimental long bone healing in dog. Connect Tissue Res. 53: 334-342.
Crossref
 
Brevini T, Antonini S, Pennaros, G, Gandolfi F (2008). Recent progress in embryonic stem cell research and its application in domestic species. Reprod. Domest. Anim. 43: 193-199.
Crossref
 
Brown S, Harman R, Black L (2012). Adipose-derived stem cell therapy for severe muscle tears in working German shepherds: Two case reports Stem Cell Discovery, 2: 41–44.
 
Clementschitsch F, Bayer K (2006). Improvement of bioprocess monitoring: development of novel concepts. Microb. Cell Fact, 5: 19.
Crossref
 
Despoina C, Helen D, Maria K (2008). Stem Cells: Promises Versus Limitations. Tissue Eng. Part B Rev. 14: 1.
 
Dhama K, Chakraborty S, Mahim M, Verma A, Deb R, Tiwari R, Kapoor S (2013). Novel and emerging therapies safeguarding health of humans and their companion animals: A review. Pak. J. Biol. Sci. 16: 101-111.
Crossref
 
Dietz A, Padley D, Gastineau D (2007). Infrastructure development for human cell therapy translation. Clin. Pharmacol. Ther. 82: 320–324.
Crossref
 
Emadedin M, Aghdami N, Taghiyar L, Fazeli R, Moghadasali R, Jahangir S, Farjad R, Baghaban E (2012). Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. Arch. Iran. Medicine. 15: 422-428.
Pubmed
 
Fuchs E, Segre J (2000). Stem cells: a new lease on life. Cell. 100: 143–55.
Crossref
 
Gade N, Pratheesh M, Nath A, Dubey P, Amarpal Y, Sharma T (2012). Therapeutic potential of stem cells in veterinary practice. Vet. World. 5: 499-507.
Crossref
 
Gade N, Pratheesh M, Nath A, Dubey K, Amarpal Y, Saikumar G, Sharma T (2012). Stem cell therapy in animal sciences - A review. Agricultural Reviews, 33: 15-158.
 
Gokhale P, Andrews P (2008). New insights into the control of stem cell pluripotency. Cell Stem Cell. 2:4-5.
Crossref
 
Guercio A, Di Marco P, Casella S, Cannella V, Russotto L, Purpari G, Di Bella S, Piccione G (2012). Production of canine mesenchymal stem cells from adipose tissue and their application in dogs with chronic osteoarthritis of the humeroradial joints. Cell Biol. Int. 36:189–194.
Crossref
 
Guest D, Smith M, Allen W (2010). Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon. Equine Vet. J. 42: 636-642.
Crossref
 
Gulotta V, Kovacevic D, Packer D, Deng H, Rodeo S (2011). Bone marrow-derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model. Am. J. Sports Med. 39: 1282-1289.
Crossref
 
Gurtner C, Callaghan J, Longaker T (2007). Progress and potential for regenerative medicine. Annu. Rev. Med. 58:299-312.
Crossref
 
Hak-Hyun R, Lim JH, Byeon YE, Park JR, Seo MS, Lee YW, Kim WH, Kang KS, Kweon OK. (2009). Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury. J. Vet. Sci. 10: 273–284.
Crossref
 
Hayashi Y, Furue MK, Okamoto T, Ohnuma K, Myoishi Y, Fukuhara Y, Abe T, Sato JD, Hata R, Asashima M (2007). Integrins regulate mouse embryonic stem cell self-renewal. Stem cells. 25: 3005-3015.
Crossref
 
Herthel J (2002). Suspensory desmitis therapies. Proc 12th ACVS Symposium pp. 165–167.
 
Jackson K, Majka S, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA (2001). Regeneration of is chemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107:1395-1402.
Crossref
 
Junker B, Wang H (2006). Bioprocess monitoring and computer control: key roots of the current PAT initiative. Biotechnol. Bioeng. 95: 226–261.
Crossref
 
Lau D, Ogbogu U, Taylor B, Stafinski T, Menon D, Caulfield T (2008). Stem cell clinics online: the direct-to consumer portrayal of stem cell medicine. Cell Stem Cell. 3: 591–594.
Crossref
 
Lim M, Ye H, Panoskaltsis N, Drakakis E, Yue X, Cass A, Radomska A, Mantalaris A (2007). Intelligent bioprocessing for haemotopoietic cell cultures using monitoring and design of experiments. Biotechnol. Adv. 25:353–368.
Crossref
 
Linheng L, Ting X (2005). Stem Cell Niche: Structure and Function. Annu. Rev. Cell Dev. Biol. 21: 605-631.
Crossref
 
Liras (2010). Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects. J. Transl. Med. 8: 131.
 
Liras A (2001). Gene therapy for haemophilia: The end of a "royal pathology" in the third millennium? Haemophilia. 7: 441-5.
Crossref
 
Lisa AF, Alexander JT (2011). Stem cells in veterinary medicine. Stem Cell Res. Ther. 9: 12-14.
 
Mantalaris A, Panoskaltsis N, Wu J (2004). Tissue engineering of bone marrow, culture systems. Encyclopedia of biomaterial and biomedical engineering. New York, NY: Marcel Dekker, Inc. pp. 1518-1525.
 
Miguel R (2002). The relevance of ethics in the progress of science. Med. Sci. Monit. 8:21-26.
 
Obermeyer T, Yonick D, Lauing K, Stock S, Nauer R, Strotman P, Shankar R, Gamelli R, Stover M, Callaci J (2012). Mesenchymal stem cells facilitate fracture repair in an alcohol-induced impaired healing model. J. Orthop. Trauma. 26: 712-718.
Crossref
 
Pai-Jiun H, Men-Luh Y, Shaw-Fang Y, Linju Y (2012). Current applications of human pluripotent stem cells: possibilities and challenges. Cell Transplant. 21: 801-814.
Crossref
 
Piedrahita (2011). The promise of regenerative medicine. Journals of biomedical science, 5:20.
 
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999). Multilineage potential of adult human mesenchymal stem cells. Science. 284: 143–147.
http://dx.doi.org/10.1126/science.284.5411.143
PMid:10102814
 
Prokai-Tatrai K, Perjesi P, Rivera-Portalatin N, Simpkins J, Prokai L (2008). Mechanistic investigations on the antioxidant action of a neuroprotective estrogen derivative. Steroids. 73: 280-288.
Crossref
 
Ribitsch I, Burk J, Delling U, Geißler C, Gittel C, Jülke H, Brehm W. (2010). Basic Science and Clinical Application of Stem Cells in Veterinary Medicine. Adv. Biochem. Eng. Biotechnol. 123:219–263.
Pubmed
 
Ricardo P, Michael FC, Sean JM (2003). Applying the principles of stem cell biology to cancer. Nat. Rev. Cancer. 3:895-902.
Crossref
 
Safinia L, Mantalaris A, Bismarck A (2006). Nondestructive technique for the characterization of the pore size distribution of soft porous constructs for tissue engineering. Langmuir. 22: 3235–3242.
Crossref
 
Schofield R (1978). The relationship between the spleen colony forming cell and the hamatopopi-etic stem cell. Blood Cells. 4: 7–25.
Pubmed
 
Spencer N, Gimble J, Lopez J (2011). Mesenchymal stromal cells: past, present, and future. Vet. Surg. 40:129-39.
Crossref
 
Stevens M, George J (2005). Exploring and engineering the cell surface interface. Science. 310:1135–1138.
Crossref
 
Sun S, Titushkin I, Cho M (2006). Regulation of mesenchymal stem cell adhesion and orientation in 3D collagen scaffold by electrical stimulus. Bioelectrochemistry 69:133–141.
Crossref
 
Sze S, de Kleijn DP, Lai RC, Khia Way Tan E, Zhao H, Yeo KS, Low TY, Lian Q, Lee CN, Mitchell W, El Oakley RM, Lim SK (2007). Elucidating the secretion proteome of human embryonic stem cell-derived mesenchymal stem cells. Mol. Cell Proteomics. 6:1680–1689.
Crossref
 
Uchida K, Ueno M, Naruse K, Urabe K, Onuma K, Sakai R, Itoman M, Takaso M (2012). Bone marrow engrafted cells after mice umbilical cord blood transplantation differentiate into osteoblastic cells in response to fracture and placement of titanium screws. Exp. Anim. 61: 427-33.
Crossref
 
University Hospitals of Cleveland (2004, November 30). Leukemia Patients Survive With Stem Cell Transplant. Science Daily Retrieved March 16, 2014, from http://www.sciencedaily.com/releases/2004/11/041129112109.htm.
 
Washington State University (WSU) (2009). WSU researching stem cells and surgical technique to heal equine suspensory ligament injuries. College of Veterinary Medicine. 6: 4.
 
West F, Terlouw S, Kwon D, Mumaw J, Dhara S, Hasneen K, Dobrinsky J, Stice S (2010). Porcine induced pluripotent stem cells produce chimeric offspring. Stem Cells Dev. 19: 1211–1220.
Crossref
 
Xu D, Alipio Z, Fink L, Adcock D, Yang J, Ward D, Ma Y (2009). Phenotypic correction of murine hemophilia A using an iPSCs cell-based therapy. Proc. Natl. Acad. Sci. U S A. 106: 808-813.
Crossref
 
Yamanaka S, Blau H (2010). Nuclear reprogramming to a pluripotent state by three approaches. Nature 465:704-712.
Crossref
 
Yao J, Woon C, Behn A, Korotkova T, Park D, Gajendran V, Smith R (2012). The effect of suture coated with mesenchymal stem cells and bioactive substrate on tendon repair strength in a rat model. J. Hand. Surg. Am. 37:1639-45.
Crossref
 
Yingling G, Nobert K (2008). Regulatory considerations related to stem cell treatment in horses. J. Am. Vet. Med. Assoc. 232: 1657–1661.
Crossref
 
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917–1920.
Crossref
 
Yue L, Rebecca A (2013). Regenerative medicine for the kidney: stem cell prospects & challenges. Clin. Transl. Med. 2:11
Crossref
 
Zandstra P, Eaves C, Piret J (1994). Expansion of hematopoietic progenitor cell populations in stirred suspension bioreactors of normal human bone marrow cells. Biotechnology 12:909–914.
Crossref
 
Zhang Q, Cheng B (2013). Tendon-derived stem cells as a new cell source for tendon tissue engineering. Front Biosci. (Landmark Ed). 18:756-764.
Crossref
 
Zhao C, Deng W, Gage F (2008). Mechanisms and functional implications of adult neurogenesis. Cell. 132: 645-660.
Crossref
 
Zhili R, Meiyan W, Zheng H, Martin S, Ananda G, Yong Y, Yang X, Xuemei F (2014). An effective approach to prevent immune rejection of human ESC-derived allograft. Cell Stem Cell. 14: 121-123.
Crossref
 
Zhongling F, Gang Z, Lei Y (2009). Neural stem cells and Alzheimer's disease: challenges and hope. Am. J. Alzheimers Dis. Other Demen 24:52-57.
Crossref
 

 


APA Dubie*, T., Admassu, B., Sisay, T., & Shiferaw, H. (2014). Basic biology and therapeutic application of stem cells in various human and animal diseases. Journal of Cell Biology and Genetics, 4(4), 40-52.
Chicago Teshager Dubie, Berhanu Admassu, Tesfaye Sisay and Hailemaryam Shiferaw  . "Basic biology and therapeutic application of stem cells in various human and animal diseases." Journal of Cell Biology and Genetics 4, no. 4 (2014): 40-52.
MLA Teshager Dubie, et al. "Basic biology and therapeutic application of stem cells in various human and animal diseases." Journal of Cell Biology and Genetics 4.4 (2014): 40-52.
   
DOI 10.5897/JCBG2014.0039
URL http://academicjournals.org/journal/JCBG/article-abstract/6BA497E49112

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