Journal of Clinical Immunology and Immunopathology Research
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Article Number - F5CCF9B5432


Vol.2(2), pp. 15-21 , August 2010

ISSN: 1996-0816



Full Length Research Paper

Association of HLA-G 14bp insertion/deletion polymorphism with autoantibody production in patients with autoimmune rheumatic diseases



Feng-Xia WU
  • Feng-Xia WU
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Li-Jun Wu
  • Li-Jun Wu
  • Department of Rheumatology, People`s Hosptial of XinJiang Uygur Autonomus Region, Urumchi, XiJiang, P. R. China.
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Xiong-Yan Luo
  • Xiong-Yan Luo
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Zhong Tang
  • Zhong Tang
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Ming-Hui Yang
  • Ming-Hui Yang
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Yan-Hui Xia
  • Yan-Hui Xia
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Chuan-Mei Xie
  • Chuan-Mei Xie
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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Ning-Tao Liu
  • Ning-Tao Liu
  • Department of Rheumatology, Suining Municipal People’s Hospital, Suining City, Sichuan, P. R. China.
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Xiao-Feng Zeng
  • Xiao-Feng Zeng
  • Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
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Jian-Long Guan
  • Jian-Long Guan
  • Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, P. R. China.
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Guo-Hua Yuan
  • Guo-Hua Yuan
  • Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, P. R. China.
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 Accepted: 21 June 2010  Published: 31 August 2010

Copyright © 2010 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


HLA-G is a non-classical HLA-class Ib molecule and has multiple immunoregulatory properties. A 14bp insertion/deletion polymorphism in the HLA-G gene has been suggested to influence the expression of HLA-G and then to associate with certain pathological conditions, including autoimmune diseases. The aim of study was to evaluate the possible association of the HLA-G 14bp insertion (+14bp) and deletion (-14bp) polymorphism with autoantibody production in patients with autoimmune rheumatic diseases. A total of 504 patients with rheumatic diseases and 367 unrelated healthy controls from a Chinese Han population were HLA-G genotyped for the 14bp insertion/deletion polymorphism. No statistically significant differences were observed in the frequencies of the HLA-G 14bp insertion/deletion alleles or genotypes between controls and patients with rheumatic disease. However, significant differences in the distribution of the HLA-G 14bp insertion/deletion polymorphism could be demonstrated for patients with positive anti-snRNP antibodies and patients with positive anti-histone antibodies when compared with the respective antibody-negative patients. The anti-snRNP antibodies positive group showed markedly increased frequencies of the +14bp allele (P = 0.0001, OR = 1.794, 95% CI = 1.329 - 2.422) as well as the +14/-14bp heterozygotes (P = 0.0001, OR = 2.306, 95% CI = 1.511 - 3.521). Moreover, an increased frequencies of the -14bp allele (P = 0.0001, OR = 2.302, 95% CI = 1.657 - 3.198) and the -14/-14bp homozygous genotype (P = 0.0001, OR = 3.035, 95% CI = 1.974 - 4.667) was observed in the patients with positive anti-histone antibodies. These findings are the first time to indicate that the HLA-G 14bp insertion/deletion polymorphism could be a genetic risk factor influencing the susceptibility for the autoantibody production in rheumatic diseases.

 

Key wordsHLA-G, polymorphism, autoantibodies, rheumatic disease.


APA (2010). Association of HLA-G 14bp insertion/deletion polymorphism with autoantibody production in patients with autoimmune rheumatic diseases. Journal of Clinical Immunology and Immunopathology Research, 2(2), 15-21.
Chicago Feng-Xia WU, Li-Jun Wu, Xiong-Yan Luo, Zhong Tang, Ming-Hui Yang, Yan-Hui Xia, Chuan-Mei Xie, Ning-Tao Liu, Xiao-Feng Zeng, Jian-Long Guan and Guo-Hua Yuan. "Association of HLA-G 14bp insertion/deletion polymorphism with autoantibody production in patients with autoimmune rheumatic diseases." Journal of Clinical Immunology and Immunopathology Research 2, no. 2 (2010): 15-21.
MLA Feng-Xia WU, et al. "Association of HLA-G 14bp insertion/deletion polymorphism with autoantibody production in patients with autoimmune rheumatic diseases." Journal of Clinical Immunology and Immunopathology Research 2.2 (2010): 15-21.
   
DOI
URL http://academicjournals.org/journal/JCIIR/article-abstract/F5CCF9B5432

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