Journal of Clinical Pathology and Forensic Medicine
Subscribe to JCPFM
Full Name*
Email Address*

Article Number - 75CF87257512


Vol.7(1), pp. 1-6 , January 2016
DOI: 10.5897/JCPFM2015.0066
ISSN: 2141-2405



Full Length Research Paper

Role of mean platelet volume in individuals with type II diabetes mellitus



Vaddatti Tejeswini*
  • Vaddatti Tejeswini*
  • Department of Pathology, NRI Medical College and General Hospital, Chinakakani, Guntur.
  • Google Scholar
P. Premalatha
  • P. Premalatha
  • Department of Pathology, NRI Medical College and General Hospital, Chinakakani, Guntur.
  • Google Scholar
P. A. V. Krishnamacharyulu
  • P. A. V. Krishnamacharyulu
  • Department of Pathology, NRI Medical College and General Hospital, Chinakakani, Guntur.
  • Google Scholar







 Received: 08 July 2015  Accepted: 03 September 2015  Published: 31 January 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Diabetes mellitus (DM) is a global pandemic. Large platelets are highly thrombotic and thus put the patient at a higher risk. Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV are associated with increased risk for hyperglycemic complications. We aimed to investigate the association of MPV, a marker for platelet size and activity with fasting blood glucose (FBS), postprandial blood glucose (PPBS), glycosylated hemoglobin (HbA1c) and duration of diabetes. We also compared MPV in diabetics and healthy controls. This is a case control study carried out in both individuals with type II diabetes mellitus and healthy controls. All the patients who attended our hospital during September 2012 to march 2013 were included in the study, taking inclusion and exclusion criteria into consideration. In 171 individuals with type II DM and 37 healthy controls, MPV and platelet counts were analyzed by fully automated hematology analyzer SEIMENS ADVIA 2120. Samples were also subjected for FBS, PPBS and HbA1c. The control and test groups were compared with Z test; difference between two means. Pearson’s coefficient of correlation (r value) was calculated to know the relationship between two variables. t Test was done to test the significance of r value obtained and p value was calculated. p Value < 0.05 is considered significant. The analysis was done by Microsoft excel sheet. MPV was significantly higher in diabetics when compared to healthy controls (7.91 + 0.87 > 6.91 + 0.71). There was also a statistically significant positive correlation between HbA1c and MPV (r value - 0.5, p value - 0.4). Though FBS and PPBS showed a negative correlation with MPV but were not statistically significant. MPV, a simple, reliable and cost effective tool can be used in diabetes mellitus as an accessory marker for monitoring vascular complications and glycemic control.

Key words: Mean platelet volume, diabetes mellitus, glycosylated hemoglobin.

Alvin CP (2011). Diabetes mellitus. In: Dennis LK, Joseph L, Anthoni SF, Stephen LH, Dan LL, Larry JJ (eds), Harrison's principles of internal medicine. 18th edition. New york. Mc Graw Hill medical publishing division. Chapter 344, pp. 2968-3001.

 

Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, Ramírez C, Sabaté M, Jimenez-Quevedo P (2005). Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 54:2430-435.
crossref

 

Brand FNM, Abbot RD, Kannel WB (1989). Diabetes, intermittent claudication, and risk of cardiovascular events: the Framingham study. Diabetes 38:504-509.
crossref

 

Corash L, Tan H, Grolnick HR. Heterogeneity of human whole blood platelet subpopulation (1977). Relationship between buoyant density, cell volume and ultrastructure. Blood 49:71-87.

 

Erikçi AA, Muhçu M, Dündar O, Oztürk A (2008). Could mean platelet volume be a predictive marker for gestational diabetes mellitus? Hematology 13:46-48.
crossref

 

Hekimsoy Z, Payzin B, Ornek T, Kandoan G (2004). Mean platelet volume in Type 2 diabetic patients. J. Diabetes Complications18:173-176.
crossref

 

Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K (2011). Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 16:86-89.
crossref

 

Jonathan M (2001). Blood platelets. John Bernard Henry editors. Clinical Diagnosis & Management By Laboratory Methods 20st edition. New Delhi. Elseviers publications. Part 4. pp. 624-641.

 

King H, Aubert RE, Herman WH (1998). Global burden of diabetes, 1995-2025: prevalence, numerical estimates and projections. Diabetes Care 21:1414-31.
crossref

 

Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, Lakshmaiah V (2012). Mean platelet volume in type 2 diabetes mellitus. J. Lab. Physicians 4(1):5-9.
crossref

 

Maitra A. The Endocrine System. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors (2010). Robbins and Cotran Pathologic Basis of Disease. 8th ed. New Delhi: Elsevier pp. 1097-1164.
crossref

 

Mathur A, Robinson MS, Cotton J, Martin JF, Erusalimsky JD (2001). Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behavior between unstable angina and myocardial infarction. Thromb. Haemost. 85(6):989-994.

 

Mitchell RN. Hemodynamic Disorders, Thromboembolic Disease and Shock. In: Kumar V, Abbas AK, Fausto N, Aster JC, editors (2010). Robbins and Cotran Pathologic Basis of Disease. 8th edition. New Delhi: Elsevier pp. 111-134.

 

Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T, Lakasaa G (2004). Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 15(8):475-8.
crossref

 

Preston FE, Ward JD, Marcola BH, Porter NR, Timperley WR, O'Malley BC (1978). Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy. Lancet 1:238-240.
crossref

 

Smith NM, Pathansali R, Bath PM (1999). Platelets and stroke. Vasc. Med. 4(3):165-172.
crossref

 

Wincour P (1992). Platelet abnormalities in diabetes mellitus. Diabetes 41:26-31.
crossref

 

Zuberi BF, Akhtar N, Afsar S (2008). Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med. J. 49:114-116.

 


APA Tejeswini, V., Premalatha, P., & Krishnamacharyulu, P. A. V. (2016). Role of mean platelet volume in individuals with type II diabetes mellitus. Journal of Clinical Pathology and Forensic Medicine, 7(1), 1-6.
Chicago Vaddatti Tejeswini, P. Premalatha and P. A. V. Krishnamacharyulu. "Role of mean platelet volume in individuals with type II diabetes mellitus." Journal of Clinical Pathology and Forensic Medicine 7, no. 1 (2016): 1-6.
MLA Vaddatti Tejeswini, P. Premalatha and P. A. V. Krishnamacharyulu. "Role of mean platelet volume in individuals with type II diabetes mellitus." Journal of Clinical Pathology and Forensic Medicine 7.1 (2016): 1-6.
   
DOI 10.5897/JCPFM2015.0066
URL http://academicjournals.org/journal/JCPFM/article-abstract/75CF87257512

Subscription Form