Journal of Cancer Research and Experimental Oncology
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Article Number - 45A6D2360297


Vol.8(4), pp. 33-40 , September 2016
DOI: 10.5897/JCREO2016.0135
ISSN: 2141-2243



Full Length Research Paper

Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis



Khaled Metwaly
  • Khaled Metwaly
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Eman Abdel Sameea
  • Eman Abdel Sameea
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Gasser El-Azab
  • Gasser El-Azab
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Medhat Assem
  • Medhat Assem
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Mohamed Abbasy
  • Mohamed Abbasy
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Talaat Zakareya
  • Talaat Zakareya
  • Department of Hepatology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar
Gamal Abo Raia
  • Gamal Abo Raia
  • Department of Clinical Pathology, National Liver Institute, Menoufiya University, Shebin El-Kom, Egypt.
  • Google Scholar







 Received: 09 July 2016  Accepted: 16 August 2016  Published: 30 September 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio in diagnosis of HCC in Egyptian patients with chronic hepatitis C related liver cirrhosis. One hundred and fifty chronic hepatitis C (CHC) patients with chronic hepatitis, cirrhosis or HCC were enrolled in the study. The levels of alphe feto protein (AFP), MPV and MPV/PC ratio were determined compared to 50 healthy persons. MPV and MPV/CP ratio were higher in patients with cirrhosis and those with HCC. The cut off level for MPV for detection of HCC was 10.1 fl, with sensitivity of 70% and specificity of 57%. At a cut off level of 0.82, the sensitivity of MPV/CP ratio was 79.6% and specificity was 72.7%. AFP showed sensitivity 80% and specificity 82% at cut-off level of 16.9 ng/dl. MPV and MPV/PC ratio are less sensitive and specific than AFP as markers for HCC; they may be used only in association with other markers to improve sensitivity of tumor detection.

 

Key words: Hepatocellular carcinoma, mean platelet volume, platelet count, cirrhosis, hepatitis C.

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APA Metwaly, K., Sameea, E. A., El-Azab, G., Assem, M., Abbasy, M., Zakareya, T., & Raia, G. A. (2016). Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis. Journal of Cancer Research and Experimental Oncology, 8(4), 33-40.
Chicago Khaled Metwaly, Eman Abdel Sameea, Gasser El-Azab, Medhat Assem, Mohamed Abbasy, Talaat Zakareya and Gamal Abo Raia. "Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis." Journal of Cancer Research and Experimental Oncology 8, no. 4 (2016): 33-40.
MLA Khaled Metwaly, et al. "Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis." Journal of Cancer Research and Experimental Oncology 8.4 (2016): 33-40.
   
DOI 10.5897/JCREO2016.0135
URL http://academicjournals.org/journal/JCREO/article-abstract/45A6D2360297

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