Journal of Cancer Research and Experimental Oncology
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Article Number - 98D395841018


Vol.5(1), pp. 1-7 , November 2013
DOI: 10.5897/JCREO2013.0101
ISSN: 2141-2243



Full Length Research Paper

Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies



Adegun P.T
  • Adegun P.T
  • Ekiti State University Teaching Hospital, Ado-Ekiti, Department of Urology, College of Medicine.
  • Google Scholar
Ogundele O.M
  • Ogundele O.M
  • Afe Babalola University, College of Medicine and Health Sciences, Department of Anatomy.
  • Google Scholar
Falode D.T
  • Falode D.T
  • Blood and Cancer Centre, American Hospitals and Resorts, Lagos, Nigeria.
  • Google Scholar
Taiwo O.J
  • Taiwo O.J
  • Ekiti State University Teaching Hospital, Ado-Ekiti, Department of Histopathology, College of Medicine.
  • Google Scholar
Ajonijebu D.C
  • Ajonijebu D.C
  • Afe Babalola University, College of Medicine and Health Sciences Department of Physiology, College II.
  • Google Scholar
Omoaghe A.O
  • Omoaghe A.O
  • Afe Babalola University, College of Medicine and Health Sciences Department of Physiology, College II.
  • Google Scholar
Kobomoje O.S
  • Kobomoje O.S
  • Afe Babalola University, College of Sciences, Department of Biological Sciences, College.
  • Google Scholar







 Accepted: 02 October 2013  Published: 30 November 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Molecular characterization of PCa and BPH using the angiogenic tissue markers CD31 and CD45 to differentiate between the two major types of prostate gland disorders is investigated. 8 clinically characterized biopsies were analyzed at the Histopathology Laboratory of the Ekiti State University Teaching Hospital; the tissue sections were processed for antigen retrieval and were labeled with anti-CD45 and anti-CD31 to map the location of angiogenic cells and vascularization in BPH and PCa. The results showed that PCa biopsies expressed embryonic stem cell status of CD31+/CD45+, while BPH showed CD31-/CD45+. This suggests the presence of migrating blood cells (vascularization) in PCa and the absence of such in BPH. It also confirms the role of platelets in endothelial activation that can result to cell proliferation and apoptosis in the prostate gland of either BPH or PCa diagnosed patients.
 
Key words: CD31, CD45, Prostate, Endothelioma, Vascularization, Angiogenesis

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APA (2013). Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies. Journal of Cancer Research and Experimental Oncology, 5(1), 1-7.
Chicago Adegun P.T, Ogundele O.M, Falode D.T, Taiwo O.J, Ajonijebu D.C, Omoaghe A.O and Kobomoje O.S. "Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies." Journal of Cancer Research and Experimental Oncology 5, no. 1 (2013): 1-7.
MLA Adegun P.T, et al. "Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies." Journal of Cancer Research and Experimental Oncology 5.1 (2013): 1-7.
   
DOI 10.5897/JCREO2013.0101
URL http://academicjournals.org/journal/JCREO/article-abstract/98D395841018

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