Journal of
Cancer Research and Experimental Oncology

  • Abbreviation: J. Cancer Res. Exp. Oncol.
  • Language: English
  • ISSN: 2141-2243
  • DOI: 10.5897/JCREO
  • Start Year: 2009
  • Published Articles: 52

Full Length Research Paper

In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration

Melvin Lee Kiang Chua
  • Melvin Lee Kiang Chua
  • Department of Radiation Oncology, National Cancer Centre, Singapore.
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Haslinda Binte Kamis
  • Haslinda Binte Kamis
  • Division of Cellular and Molecular Research, National Cancer Centre, Singapore.
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Jonathan Yi Hui Teh
  • Jonathan Yi Hui Teh
  • Department of Radiation Oncology, National Cancer Centre, Singapore.
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Susan Li Er Loong
  • Susan Li Er Loong
  • Department of Radiation Oncology, National Cancer Centre, Singapore.Division of Cellular and Molecular Research, National Cancer Centre, Singapore.
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  • Article Number - 9B3CDB51380
  • Vol.1(1), pp. 008-011, October 2009
  •  Accepted: 21 August 2009
  •  Published: 31 October 2009

Abstract

In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has not yet been studied.  Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells.  When  incubated  with  COX-2  inhibitors  prior  to  irradiation,  increased  radiation  cell  kill was documented. However, when the sequence of COX-2 administration was reversed, we observed radioprotection instead. Our findings  hereby  confirmed  the  enhancement  effect  of  COX-2  inhibitors  on  radiation cell kill in vitro, but this effect is critically dependent on their  sequence of administration.     

 

Key words: Cyclooxygenase-2, inhibitors, nasopharyngeal carcinoma,  radiosen-sitization, radioprotection