Journal of Cancer Research and Experimental Oncology
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Article Number - 9B3CDB51380


Vol.1(1), pp. 008-011 , October 2009

ISSN: 2141-2243



Full Length Research Paper

In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration



Melvin Lee Kiang Chua
  • Melvin Lee Kiang Chua
  • Department of Radiation Oncology, National Cancer Centre, Singapore.
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Haslinda Binte Kamis
  • Haslinda Binte Kamis
  • Division of Cellular and Molecular Research, National Cancer Centre, Singapore.
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Jonathan Yi Hui Teh
  • Jonathan Yi Hui Teh
  • Department of Radiation Oncology, National Cancer Centre, Singapore.
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Susan Li Er Loong
  • Susan Li Er Loong
  • Department of Radiation Oncology, National Cancer Centre, Singapore.Division of Cellular and Molecular Research, National Cancer Centre, Singapore.
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 Accepted: 21 August 2009  Published: 31 October 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has not yet been studied.  Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells.  When  incubated  with  COX-2  inhibitors  prior  to  irradiation,  increased  radiation  cell  kill was documented. However, when the sequence of COX-2 administration was reversed, we observed radioprotection instead. Our findings  hereby  confirmed  the  enhancement  effect  of  COX-2  inhibitors  on  radiation cell kill in vitro, but this effect is critically dependent on their  sequence of administration.     

 

Key words: Cyclooxygenase-2, inhibitors, nasopharyngeal carcinoma,  radiosen-sitization, radioprotection


APA (2009). In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration. Journal of Cancer Research and Experimental Oncology, 1(1), 008-011.
Chicago Melvin  Lee  Kiang  Chua,  Haslinda  Binte  Kamis,  Jonathan  Yi  Hui  Tehand Susan  Li  Er  Loong,. "In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration." Journal of Cancer Research and Experimental Oncology 1, no. 1 (2009): 008-011.
MLA Melvin Lee Kiang Chua, et al. "In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration." Journal of Cancer Research and Experimental Oncology 1.1 (2009): 008-011.
   
DOI
URL http://academicjournals.org/journal/JCREO/article-abstract/9B3CDB51380

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