Journal of Cancer Research and Experimental Oncology
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Article Number - 9D34B391470


Vol.1(2), pp. 015-019 , December 2009

ISSN: 2141-2243



Full Length Research Paper

Silver binding nucleolar organiser regions in oral submucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma



Sunita Kulkarni
  • Sunita Kulkarni
  • Department of Oral Medicine and Radiology, M. M College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
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R. N. Mody
  • R. N. Mody
  • Department of Oral Medicine and Radiology, Govt. Dental College, Nagpur, Maharashtra, India.
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Sanjeev Jindal
  • Sanjeev Jindal
  • Department of Oral Medicine and Radiology, Bhojia Dental College and Hospital, Vill. Budh, Baddi, Distt. Solan, Himachal Pradesh, India.
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Ravinder Singh Sohi
  • Ravinder Singh Sohi
  • Department of Oral medicine and Radiology, M. M College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
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Bhawandeep Kaur
  • Bhawandeep Kaur
  • Department of Oral medicine and Radiology, M. M College of Dental Sciences and Research, Mullana, Ambala, Haryana, India.
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 Accepted: 06 November 2009  Published: 31 December 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


This study was undertaken to assess the biologic aggressiveness of sub mucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma of the oral cavity by determining the mean number of AgNORs and comparing them with those of normal mucosa. The study sample consisted of total 93 subjects. Biopsy specimens of 26 squamous cell carcinomas, 22 sub mucous fibrosis, 15 lichen planus, 15 leukoplakia and 15 healthy oral mucosa were taken. AgNORs were assessed both quantitatively and qualitatively. The data were analyzed using Student's independent t-test. Quantitatively significant difference existed in the number of AgNORs between the normal mucosa, premalignant lesions and carcinomas. AgNOR quantity is strictly proportional to the proliferative activity of the cell and does not necessarily indicate malignancy. It is the qualitative characteristics of AgNOR that help to differentiate premalignant and malignant lesions.

 

Key words: AgNORS, nucleolar organizer regions, oral cancer, potentially malignan


APA (2009). Silver binding nucleolar organiser regions in oral submucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma. Journal of Cancer Research and Experimental Oncology, 1(2), 015-019.
Chicago Sunita Kulkarni, R. N. Mody, Sanjeev Jindal, Ravinder Singh Sohiand Bhawandeep Kaur. "Silver binding nucleolar organiser regions in oral submucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma." Journal of Cancer Research and Experimental Oncology 1, no. 2 (2009): 015-019.
MLA Sunita Kulkarni, et al. "Silver binding nucleolar organiser regions in oral submucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma." Journal of Cancer Research and Experimental Oncology 1.2 (2009): 015-019.
   
DOI
URL http://academicjournals.org/journal/JCREO/article-abstract/9D34B391470

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