Journal of
Cancer Research and Experimental Oncology

  • Abbreviation: J. Cancer Res. Exp. Oncol.
  • Language: English
  • ISSN: 2141-2243
  • DOI: 10.5897/JCREO
  • Start Year: 2009
  • Published Articles: 52

Full Length Research Paper

Stage dependent expression of MUC1 glycoprotein in gallbladder carcinoma

K. Sanjeev Maurya
  • K. Sanjeev Maurya
  • Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
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Mallika Tewari
  • Mallika Tewari
  • Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
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K. Mahendra Thakur
  • K. Mahendra Thakur
  • Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi, India.
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Mohan Kumar
  • Mohan Kumar
  • Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
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S. Hari Shukla
  • S. Hari Shukla
  • Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
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  • Article Number - DB0D5C71360
  • Vol.1(1), pp. 001-007, October 2009
  •  Accepted: 04 September 2009
  •  Published: 31 October 2009

Abstract

Gallbladder carcinoma is a relatively aggressive and frequently lethal cancer. It is defined as a clinicopathological presentation including a wide spectrum of lethal disease from simple gallstones to dysplasia, to carcinoma in situ and invasive carcinoma. MUC1, a cell surface antigen expressed in glandular epithelia, is overexpressed and aberrantly glycosylated in adenocarcinoma. In this report, the immunohistochemical and immunofuorescence expression of MUC1 was studied in formalin-fixed, paraffin-embedded surgical specimens from patients with gallbladder carcinomas. In T2 tumor, 48.3% cases showed weak expression and 51.7% showed moderate expression. In T3 tumors, expression was weak in 23.1 %, moderate in 46.2% and strong in 30.8% of cases. In T4 tumors, 9.1% cases showed weak, 40.9% moderate and 50% strong expression of MUC1. We have shown that early gallbladder cancer pathology may involve MUC1 in the disease progression. We have defined the localization of expression of the MUC1 genes during GBC development and correlated them with expression and its stage dependent nature.

 

Key words: Gallbladder carcinoma, metastasis, membrane protein, cancer diagnosis.