Journal of Cancer Research and Experimental Oncology
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Article Number - DB3BC0942284


Vol.6(1), pp. 6-12 , January 2014
DOI: 10.5897/JCREO11.046
ISSN: 2141-2243



Full Length Research Paper

Levonorgestrel-releasing intrauterine device for management of tamoxifen-induced menorrhagia in breast cancer patients



Mohamed Anwar El-Nory
  • Mohamed Anwar El-Nory
  • Departments of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Egypt.
  • Google Scholar
Gamal I. El-Habbaa
  • Gamal I. El-Habbaa
  • Departments of Obstetrics & Gynecology, Faculty of Medicine, Benha University, Egypt.
  • Google Scholar
Gamal Ibrahim Rageh
  • Gamal Ibrahim Rageh
  • Departments of General Surgery, Faculty of Medicine, Benha University, Egypt.
  • Google Scholar







 Accepted: 12 March 2013  Published: 31 January 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


This study aimed to evaluate the therapeutic yield of levonorgestrel-releasing intrauterine device (LNG-IUD) for management of tamoxifen induced menorrhagia in women who had mastectomy for treatment of breast cancer. This study included 34 patients who had breast cancer, underwent mastectomy, were maintained on tamoxifen post-operatively for at least 6 months, and had also newly developed menorrhagia throughout their follow-up period. All the patients underwent clinical examination for determination of duration and heaviness of menstrual blood loss (MBL), transvaginal ultrasonography (TVU) and endometrial biopsy for exclusion of abnormal pathology, estimation of blood iron indices and quality of life (QoL) scoring. Baseline endometrial biopsy detected simple endometrial hyperplasia (EH) in 4 patients and 30 patients had proliferative endometrium. Three patients were excluded and 31 patients completed the follow-up period without the need for shift to hysterectomy. Both mean duration and heaviness of MBL showed significant progressive decrease throughout the observation period as compared to baseline data. At the end of follow-up period, 5 women became amenorrheic, 2 women had moderate MBL and 24 women had mild MBL. Iron indices studies showed significant improvement at the end of follow-up as compared to baseline indices and total QoL scoring recorded at 6 and 12 months after enrollment were significantly higher as compared to baseline scores with significantly higher scores at 12 months.  LNG-IUD could be considered as an appropriate therapeutic modality for tamoxifen-induced menorrhagia in patients who had mastectomy for breast cancer with significant reduction of duration and severity of MBL and improved QoL and iron indices.

Key words: Levonorgestrel-releasing intrauterine device, mastectomy, menstrual blood loss, transvaginal ultrasonography.

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APA El-Nory, M.A., El-Habbaa, G.I., & Rageh, G.I. (2014). Levonorgestrel-releasing intrauterine device for management of tamoxifen-induced menorrhagia in breast cancer patients. Journal of Cancer Research and Experimental Oncology, 6(1), 6-12.
Chicago Mohamed Anwar El-Nory,  Gamal I. El-Habbaa and Gamal Ibrahim Rageh. "Levonorgestrel-releasing intrauterine device for management of tamoxifen-induced menorrhagia in breast cancer patients." Journal of Cancer Research and Experimental Oncology 6, no. 1 (2014): 6-12.
MLA Mohamed Anwar El-Nory,  Gamal I. El-Habbaa and Gamal Ibrahim Rageh. "Levonorgestrel-releasing intrauterine device for management of tamoxifen-induced menorrhagia in breast cancer patients." Journal of Cancer Research and Experimental Oncology 6.1 (2014): 6-12.
   
DOI 10.5897/JCREO11.046
URL http://academicjournals.org/journal/JCREO/article-abstract/DB3BC0942284

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