Journal of Diabetes and Endocrinology
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Article Number - 2E37CE452746


Vol.6(4), pp. 19-24 , April 2015
DOI: 10.5897/JDE2015.0086
ISSN: 2141-2685



Full Length Research Paper

Dyslipidemia among diabetic patients in Southern Ethiopia: Cross-sectional study



Henock Ambachew*
  • Henock Ambachew*
  • Department of Medical Laboratory Sciences, Hawassa University, P.O. Box 1560, Hawassa, Ethiopia.
  • Google Scholar
Techalew Shimelis
  • Techalew Shimelis
  • Department of Medical Laboratory Sciences, Hawassa University, P.O. Box 1560, Hawassa, Ethiopia.
  • Google Scholar
Kinfe Lemma
  • Kinfe Lemma
  • Department of Internal Medicine, Hawassa University, P.O. Box 1560, Hawassa, Ethiopia.
  • Google Scholar







 Received: 14 April 2015  Accepted: 29 April 2015  Published: 30 April 2015

Copyright © 2015 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Diabetes mellitus (DM) is a common endocrine metabolic disorder and a leading cause of death worldwide. Dyslipidemia is a well-recognized manifestation of uncontrolled DM, because insulin has important regulatory effects on lipid metabolism. This study was conducted to determine the frequency and pattern of dyslipidaemia in diabetic patients. Cross-sectional study was conducted on a total of two hundred ninety five diabetic patients attending diabetic follow-up clinic of Hawassa University Referral Hospital from March to November, 2014. For each selected subject, structured questionnaire about socio-demographic characteristics and diabetic related information was filled; overnight fasting blood samples were analyzed for fasting blood sugar (FBS) and lipid profiles, namely, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Dyslipidemia was assessed according to the United State National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP-III) model guideline. SPSS version 20 was used as tool for data analysis. P-value of <0.05 was used as statistical significance. The mean (± standard deviation, SD) values of TC, TG, HDL, LDL were 186.03 (± 37.40), 194.33 (± 93.38), 49.66 (± 10.34), 119.15 (± 42.33) mg/dl, respectively. Among all of the diabetic patients, 34.9% had high serum LDL, 34.6% had hypercholesterolemia, 29.8% had hypertriglyceridemia and 12.2% had low HDL. Significantly higher mean serum levels of TC (p = 0.002) and LDL (p = 0.008) were noted in type 2 DM than type 1 DM. Females had significantly higher TC and LDL levels than males; whereas males had significantly lower HDL levels as compared to females (48.04 ± 9.13 versus 51.93 ± 11.49 mg/dl; p < 0.001). The mean (± SD) FBS level was 178.18(± 85.39) mg/dl and patients with type 1 DM had significantly higher FBS than those with type 2 DM (p < 0.001). Our study showed the presence of dyslipidaemia in Ethiopians with DM. The most common dyslipidemia in this study was high level of serum LDL followed by hypercholesterolemia and hypertriglyceridemia. The optimal care for diabetic patients should also include routine monitoring of serum lipid profile.

 

Key words: Diabetes, lipid profile, dyslipidemia.

Abbreviation:

DM, Diabetes mellitus; HDL, high density lipoprotein; LDL, low density lipoprotein; TC, total cholesterol; TG, triglycerides; T1DM, type 1 diabetes mellitus; T2DM, type 2 Diabetes Mellitus; NCEP-ATP, National Cholesterol Education Program, Adult Treatment Panel.


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APA Ambachew*, H., Shimelis, T., & Lemma, K. (2015). Dyslipidemia among diabetic patients in Southern Ethiopia: Cross-sectional study. Journal of Diabetes and Endocrinology, 6(4), 19-24.
Chicago Henock Ambachew, Techalew Shimelis and Kinfe Lemma  . "Dyslipidemia among diabetic patients in Southern Ethiopia: Cross-sectional study." Journal of Diabetes and Endocrinology 6, no. 4 (2015): 19-24.
MLA Henock Ambachew, Techalew Shimelis and Kinfe Lemma  . "Dyslipidemia among diabetic patients in Southern Ethiopia: Cross-sectional study." Journal of Diabetes and Endocrinology 6.4 (2015): 19-24.
   
DOI 10.5897/JDE2015.0086
URL http://academicjournals.org/journal/JDE/article-abstract/2E37CE452746

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