Journal of Diabetes and Endocrinology
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Article Number - 38319EC833


Vol.1(3), pp. 27-35 , June 2010

ISSN: 2141-2685



Full Length Research Paper

Hypoadiponectinemia: A link between visceral obesity and metabolic syndrome


Rosario Scaglione1*, Tiziana Di Chiara1, Christiano Argano2, Salvatore Corrao1and Giuseppe Licata1




1Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.

2Dipartimento di Medicina Interna, Fondazione San Raffaele Giglio, Cefalù, Palermo, Italy.


Email: rosarioscaglione@yahoo.It






 Accepted: 06 May 2010  Published: 30 June 2010

Copyright © 2010 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Metabolic syndrome (MetS) represents a combination of cardio-metabolic risk factors, including visceral obesity, glucose intolerance or type 2 diabetes, elevated triglycerides, reduced HDL cholesterol, and hypertension. MetS is rapidly increasing and prevalent worldwide as a consequence of the “epidemic” obesity, with a considerable impact on the global incidence of cardiovascular disease and type 2 diabetes. At present, some authors are disappointed on the role of insulin resistance as unifying factor in the occurrence of all the MetS components, whereas the role of visceral obesity is increasing. This review summarizes and critically evaluates the clinical and scientific evidence supporting the existence of MetS as a “fatal consequence of visceral obesity”. In view of this, the effects of some adipocytokines and other proinflammatory factors produced by fat accumulation on the occurrence of the MetS have been also emphasized. Accordingly, the “hypoadiponectinemia” has been proposed as the most interesting new hypothesis to explain the pathophysiology of MetS.

 

Key words: Metabolic syndrome, visceral obesity, adipocytokines, adiponectin, cardiovascular disease.


APA (2010). Hypoadiponectinemia: A link between visceral obesity and metabolic syndrome. Journal of Diabetes and Endocrinology, 1(3), 27-35.
Chicago Rosario Scaglione, Tiziana Di Chiara, Christiano Argano, Salvatore Corraoand Giuseppe Licata. "Hypoadiponectinemia: A link between visceral obesity and metabolic syndrome." Journal of Diabetes and Endocrinology 1, no. 3 (2010): 27-35.
MLA Rosario Scaglione, et al. "Hypoadiponectinemia: A link between visceral obesity and metabolic syndrome." Journal of Diabetes and Endocrinology 1.3 (2010): 27-35.
   
DOI
URL http://academicjournals.org/journal/JDE/article-abstract/38319EC833

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