Journal of Diabetes and Endocrinology
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Article Number - 718032158653


Vol.7(1), pp. 1-5 , April 2016
DOI: 10.5897/JDE2015.0091
ISSN: 2141-2685



Case Report

Ectopic growth hormone-releasing hormone (GHRH) acromegaly secondary to adrenal phaeochromocytoma: A case report



Eswari Chinnasamy
  • Eswari Chinnasamy
  • Diabetes and Endocrinology, Thomas Addison Unit, St George’s Healthcare NHS Trust London UK.
  • Google Scholar
Darshi Sivakumaran
  • Darshi Sivakumaran
  • Diabetes and Endocrinology, Thomas Addison Unit, St George’s Healthcare NHS Trust London UK.
  • Google Scholar
Gideon Mlawa
  • Gideon Mlawa
  • Diabetes and Endocrinology, Thomas Addison Unit, St George’s Healthcare NHS Trust London UK.
  • Google Scholar
Gul Bano
  • Gul Bano
  • Diabetes and Endocrinology, Thomas Addison Unit, St George’s Healthcare NHS Trust London UK.
  • Google Scholar







 Received: 11 November 2015  Accepted: 28 April 2016  Published: 30 April 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Ectopic growth hormone releasing hormone (GHRH) secretion is a rare cause of acromegaly and accounts for <1% of cases. It is most commonly secondary to gastropancreatic neuroendocrine tumours and bronchial carcinoid tumours. We report a case of 57 years old man with adrenal phaeochromocytoma and acromegaly due to ectopic GHRH secretion in a patient with neurofibromatosis type 1. He presented with headache, sweating and newly diagnosed diabetes. The diagnosis was of acromegaly and pheochromocytoma was confirmed on investigations and imaging. Surgical removal of the pheochromocytoma in this case resulted in resolution of his diabetes, normalisation of his IGF-1 with adequate GH suppression on oral glucose tolerance test (OGTT) and regression of enlarged pituitary on postoperative magnetic resonance imaging (MRI) scan. To our knowledge, this is the first case of acromegaly associated with pheochromocytoma due to ectopic GHRH in a patient of neurofibromatosis in literature.

Key words: Growth hormone releasing hormone (GHRH), pheochromocytoma, acromegaly, somatotrophs, neurofibromatosis.

Abbreviation:

GHRH, Growth hormone releasing hormone; OGTT, oral glucose tolerance test.


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APA Chinnasamy, E., Sivakumaran, D., Mlawa, G., & Bano, G. (2016). Ectopic growth hormone-releasing hormone (GHRH) acromegaly secondary to adrenal phaeochromocytoma: A case report. Journal of Diabetes and Endocrinology, 7(1), 1-5.
Chicago Eswari Chinnasamy, Darshi Sivakumaran, Gideon Mlawa and Gul Bano. "Ectopic growth hormone-releasing hormone (GHRH) acromegaly secondary to adrenal phaeochromocytoma: A case report." Journal of Diabetes and Endocrinology 7, no. 1 (2016): 1-5.
MLA Eswari Chinnasamy, et al. "Ectopic growth hormone-releasing hormone (GHRH) acromegaly secondary to adrenal phaeochromocytoma: A case report." Journal of Diabetes and Endocrinology 7.1 (2016): 1-5.
   
DOI 10.5897/JDE2015.0091
URL http://academicjournals.org/journal/JDE/article-abstract/718032158653

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