Journal of Evolutionary Biology Research
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Article Number - D5D0F6A4559


Vol.5(1), pp. 1-5 , February 2013
DOI: 10.5897/JEBR2012.0042
ISSN: 2141-6583



Full Length Research Paper

Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat


Somaya M. Ismail




Zoology department, Faculty of Science, Cairo University, Egypt


Email: fab200656@yahoo.com






 Accepted: 13 February 2013  Published: 28 February 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Malathion is a chemical pesticide, commonly used by Egyptian farmers; however, its contamination of water sources has become an important issue. It is suggested that the role of vitamin C in alteration of enzymes responsible for energy metabolism was induced by administration of Malathion. The effect of malathion and malathion with vitamin C on some enzymes in the rat were recorded in the present study. Significant increases in the level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma glutamyl transpeptidase) were recorded. Furthermore, renal markers such as urea, cholesterol and creatinine were increased in rats treated with malathion. Additionally, serum triglyceride was significantly decreased. No significant changes were observed in total protein, albumin and bilirubin in all treated groups as compared to the control. The present results showed that a significant (p < 0.001) decrease in glycolytic enzymes (hexokinase, pyruvatekinase, glucose phosphate isomerase and phosphofructokinase) were observed in treated groups, and lactate dehydrogenase enzyme activity also showed significant (< 0.01) reduction. Co-administration of vitamin C to the groups restored all the parameters cited above to near-normal values. Therefore, the present investigation revealed that vitamin C appeared to be a promising agent for protection against malathion–induced toxicity.

Key words: Malathion pesticide, male albino rat, biochemical toxicity.


APA (2013). Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat. Journal of Evolutionary Biology Research, 5(1), 1-5.
Chicago Somaya M. Ismail. "Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat." Journal of Evolutionary Biology Research 5, no. 1 (2013): 1-5.
MLA Somaya M. Ismail. "Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat." Journal of Evolutionary Biology Research 5.1 (2013): 1-5.
   
DOI 10.5897/JEBR2012.0042
URL http://academicjournals.org/journal/JEBR/article-abstract/D5D0F6A4559

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