Journal of General and Molecular Virology
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Article Number - 0CC94B144464


Vol.6(1), pp. 1-5 , May 2014
DOI: 10.5897/JGMV2013.0054
ISSN: 2141-6648



Full Length Research Paper

Subgenogroup B5 maintains its supremacy over other human Enterovirus71 strains that circulated in Malaysia from 2010 to 2012



Mohd Apandi Yusof*
  • Mohd Apandi Yusof*
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Hariyati Md Ali
  • Hariyati Md Ali
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Hamadah Mohammad Shariff
  • Hamadah Mohammad Shariff
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Noor Khairunnisa Ramli
  • Noor Khairunnisa Ramli
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Zarina Mohd Zawawi
  • Zarina Mohd Zawawi
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Syarifah Nur Aisyatun
  • Syarifah Nur Aisyatun
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Jasinta Anak Dennis
  • Jasinta Anak Dennis
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar
Zainah Saat
  • Zainah Saat
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
  • Google Scholar







 Received: 30 September 2013  Accepted: 05 May 2014  Published: 31 May 2014

Copyright © 2014 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Human enterovirus71 (HEV71) is responsible for hand, foot and mouth diseases (HFMD). Several outbreaks of HFMD were associated with severe neurological disease and deaths. In Malaysia, outbreaks normally occur periodically every two to three years but HEV71 were isolated throughout the year from HFMD cases. From 2010 to 2012, HEV71 strains were isolated from 37 children presented with typical HFMD. All isolates were sequenced and BLAST searched. A phylogenetic tree constructed based on the complete VP1 gene showed that all isolates belonged to subgenogroup B5. This subgenogroup has been found dominant since 2003.

Key words: Human enterovirus71, molecular epidemiology, gene sequences, circulating subgenogroup.

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APA Yusof, M. A., Ali, H. M., Shariff, H. M., Ramli, N. K., Zawawi, Z. M., Aisyatun, S. N., Dennis, J. A., & Saat, Z. (2014). Subgenogroup B5 maintains its supremacy over other human Enterovirus71 strains that circulated in Malaysia from 2010 to 2012. Journal of General and Molecular Virology, 6(1), 1-5.
Chicago Mohd Apandi Yusof,  Hariyati Md Ali, Hamadah Mohammad Shariff, Noor Khairunnisa Ramli, Zarina Mohd Zawawi, Syarifah Nur Aisyatun, Jasinta Anak Dennis and Zainah Saat. "Subgenogroup B5 maintains its supremacy over other human Enterovirus71 strains that circulated in Malaysia from 2010 to 2012." Journal of General and Molecular Virology 6, no. 1 (2014): 1-5.
MLA Mohd Ap, et al. "Subgenogroup B5 maintains its supremacy over other human Enterovirus71 strains that circulated in Malaysia from 2010 to 2012." Journal of General and Molecular Virology 6.1 (2014): 1-5.
   
DOI 10.5897/JGMV2013.0054
URL http://academicjournals.org/journal/JGMV/article-abstract/0CC94B144464

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