Journal of
General and Molecular Virology

  • Abbreviation: J. Gen. Mol. Virol.
  • Language: English
  • ISSN: 2141-6648
  • DOI: 10.5897/JGMV
  • Start Year: 2009
  • Published Articles: 32

Full Length Research Paper

Subgenogroup B5 maintains its supremacy over other human Enterovirus71 strains that circulated in Malaysia from 2010 to 2012

Mohd Apandi Yusof*
  • Mohd Apandi Yusof*
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Hariyati Md Ali
  • Hariyati Md Ali
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Hamadah Mohammad Shariff
  • Hamadah Mohammad Shariff
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Noor Khairunnisa Ramli
  • Noor Khairunnisa Ramli
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Zarina Mohd Zawawi
  • Zarina Mohd Zawawi
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Syarifah Nur Aisyatun
  • Syarifah Nur Aisyatun
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Jasinta Anak Dennis
  • Jasinta Anak Dennis
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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Zainah Saat
  • Zainah Saat
  • Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia
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  •  Received: 30 September 2013
  •  Accepted: 05 May 2014
  •  Published: 31 May 2014

Abstract

Human enterovirus71 (HEV71) is responsible for hand, foot and mouth diseases (HFMD). Several outbreaks of HFMD were associated with severe neurological disease and deaths. In Malaysia, outbreaks normally occur periodically every two to three years but HEV71 were isolated throughout the year from HFMD cases. From 2010 to 2012, HEV71 strains were isolated from 37 children presented with typical HFMD. All isolates were sequenced and BLAST searched. A phylogenetic tree constructed based on the complete VP1 gene showed that all isolates belonged to subgenogroup B5. This subgenogroup has been found dominant since 2003.

Key words: Human enterovirus71, molecular epidemiology, gene sequences, circulating subgenogroup.