Journal of General and Molecular Virology
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Article Number - D5DF7B710887


Vol.3(1), pp. 18-26 , January 2011

ISSN: 2141-6648



Full Length Research Paper

Molecular epidemiology of human enterovirus71 (HEV71) strains isolated in Peninsular Malaysia and Sabah from year 2001 to 2009


Mohd Apandi Yusof*, Fazilah Rais, Maizatul Akma Abdullah, Liyana Ahmad Zamri, Hariyati Md Ali, Fauziah Md Kassim and Zainah Saat




Virology Unit, Infectious Disease Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia.


Email: apandi@imr.gov.my






 Accepted: 30 October 2010  Published: 31 January 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Human enterovirus71 (HEV71) together with other enteroviruses such as Coxsackie A16 and Coxsackie A10 is known to be responsible for hand, foot and mouth disease. Several of the hand, foot and mouth disease (HFMD) outbreaks caused by HEV71 were associated with neurological manifestations and deaths. In Peninsular Malaysia and Sabah, even though huge outbreaks of HFMD have never been reported; HEV71 strains however, were isolated periodically from HFMD cases throughout the year. From 2001 to 2009, four genetic lineages of HEV71 have been found to be prevalent in Peninsular Malaysia and Sabah. The predominant circulating strain was subgenogroup B4 in 2001 and this was later followed by subgenogroup B5 in 2003. The subgenogroup B5 was dominant between 2005 and 2009. Viruses belonging to subgenogroups C1 and C4 were also detected.

 

Key words: Human enterovirus, neurological diseases, molecular epidemiology, gene sequences


APA (2011). Molecular epidemiology of human enterovirus71 (HEV71) strains isolated in Peninsular Malaysia and Sabah from year 2001 to 2009. Journal of General and Molecular Virology, 3(1), 18-26.
Chicago Mohd Apandi Yusof, Fazilah Rais, Maizatul Akma Abdullah, Liyana Ahmad Zamri, Hariyati Md Ali, Fauziah Md Kassim and Zainah Saat. "Molecular epidemiology of human enterovirus71 (HEV71) strains isolated in Peninsular Malaysia and Sabah from year 2001 to 2009." Journal of General and Molecular Virology 3, no. 1 (2011): 18-26.
MLA Mohd Ap, et al. "Molecular epidemiology of human enterovirus71 (HEV71) strains isolated in Peninsular Malaysia and Sabah from year 2001 to 2009." Journal of General and Molecular Virology 3.1 (2011): 18-26.
   
DOI
URL http://academicjournals.org/journal/JGMV/article-abstract/D5DF7B710887

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