Journal of Infectious Diseases and Immunity
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Article Number - 5FFF20A3430


Vol.3(1), pp. 14-16 , January 2011

ISSN: 2141-2375



Short Communication

Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children


Mehmet Akin*, Özlem Şahin, Kazim Küçüktaşci, Burçin  Kaya, Ersin Gozkeser, Murat Çağlar and Firat Erdoğan




Department of Pediatric Hematology, Faculty of Medicine, Pamukkale University,

Denizli, Turkey.


Email: drmehmetakin@yahoo.com.tr






 Accepted: 22 December 2010  Published: 31 January 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Primary Epstein-Barr virus infection in children is usually asymptomatic, but some children or young adults manifest infectious mononucleosis with typical symptoms of fever, pharyngitis, lymphadenopathy, hepatosplenomegaly and a typical lymphocytosis. The infection caused by Epstein-Barr Virus (EBV) can be followed by immunological complications. One of these is autoimmune hemolytic anemia (AIHA) that it is rare but well known ~1:1000 patients with infectious mononucleosis. Two male patients, aged 2  and 2.5 years old  with autoimmune hemolytic anemia  caused by Epstein-Barr virus admitted to our hospital with pallor, palpitation, fever and scleral icterus. Viral capsid antigen -IgM was positive in both cases, indicating the presence of primary Epstein-Barr virus infection. AIHA risk of EBV infection in the first two weeks  might be considered closely because of life threatening complications such as autoimmune hemolytic anemia.

 

Key words: Epstein-Barr Virus, coombs positive, autoimmune hemolytic anemia.


APA (2011). Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children. Journal of Infectious Diseases and Immunity, 3(1), 14-16.
Chicago Mehmet Akin, Özlem Şahin, Kazim Küçüktaşci, Burçin  Kaya, Ersin Gozkeser, Murat Çağlar and Firat Erdoğan. "Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children." Journal of Infectious Diseases and Immunity 3, no. 1 (2011): 14-16.
MLA Mehmet Akin, et al. "Direct antiglobulin test (Coombs’) positive autoimmune hemolytic anemia induced by Epstein-Barr virus infectious mononucleosis in two children." Journal of Infectious Diseases and Immunity 3.1 (2011): 14-16.
   
DOI
URL http://academicjournals.org/journal/JIDI/article-abstract/5FFF20A3430

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