Journal of Infectious Diseases and Immunity
Subscribe to JIDI
Full Name*
Email Address*

Article Number - 654ED6852558


Vol.7(2), pp. 7-13 , May 2015
DOI: 10.5897/JIDI2014.0143
ISSN: 2141-2375



Full Length Research Paper

Thrombocytopenia and bleeding manifestations among patients with dengue virus infection in Port Sudan, Red Sea State of Sudan



Bashir, A.B.*
  • Bashir, A.B.*
  • 1Hematology Department, Medical laboratory Sciences Division, Port Sudan Ahlia College, Port Sudan, Sudan.
  • Google Scholar
Mohammed, B.A.
  • Mohammed, B.A.
  • Sudan Medical Specialization Board, Academic secretary, Khartoum, Sudan.
  • Google Scholar
Saeed, O.K.
  • Saeed, O.K.
  • Department of Medicine Faculty of Medicine, University of Gizera Wad Medani, Sudan.
  • Google Scholar
Ageep, A.K.
  • Ageep, A.K.
  • Department of Pathology, Faculty of Medicine, Red Sea University, Port Sudan, Sudan.
  • Google Scholar







 Received: 14 August 2014  Accepted: 30 March 2015  Published: 31 May 2015

Copyright © 2015 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Dengue is a global endemic and most prevalent human arbovirus disease. This study aimed at evaluating thrombocytopenia and to find out platelet activation in dengue across the spectrum of the disease. A prospective study was conducted from February, 2013 to June, 2014 at Port Sudan Teaching Hospital, Red Sea State, Sudan. 334 cases of dengue caused by dengue virus along with 101 cases of control were enrolled. Laboratory-positive dengue cases were confirmed by immune chromatography and World Health Organization (WHO) criteria were used for classifying the dengue severity. Platelet counts (PLT) and platelet distribution width (PDW) were measured. Out of 334, 289 patients had dengue fever (DF) and 45 patients had dengue haemorrhagic fever (DHF). Thrombocytopenia was present in 234 (81%) DF cases and 45 (100%) DHF cases. Bleeding manifestation was seen in 35 (10.5%) patients. Haematuria (5.7%), haematamesis (0.3%), haemoptysis (0.3%), epistaxis (1.5%), and gum bleed (2.7%) are the common forms of bleeding. PLT and PDW were found to be significantly low and high in case of dengue (P < 0.000), respectively. Thrombocytopenia (low PLT) and high PDW shows considerable sensitivity for dengue virus infection.

 

Key words: Dengue, thrombocytopenia, bleeding manifestations, PDW, Port Sudan.

Ali KA, Abu ES (2012). A correlation study between clinical manifestation of dengue fever and degree of liver injury. J. Microbiol. Antimicrob. 4(2):45-48.
 
Ali KA, Malik A, Elkarsani M (2006). Clinical presentation and laboratory finding in suspected cases of dengue virus. Saudi Med. J. 27(11): 1711-1713.
 
Avila-Aguero ML, Avila-Aguero CR, Um SL, Soriano-Fallas A, Canas-Coto A, Yan SB (2004). Systemic host inflammatory and coagulation response in the dengue virus primoinfection. Cytokine 27(6):173-9.
Crossref
 
Ayyub M, Khazinder AM, Lubbad EH, Barlas S, Alfi AY, Al-Ukayli S (2006). Characteristic of dengue fever in a large public hospital, Jeddah, Saudi Arabia. J. Ayub. Med. Coll. Abbottabad 18(2):9-13.
Pubmed
 
Chairulfatah A, Setiabudi D, Agoes R, Colebunder R (2003). Thrombocytopenia and platelet transfusions in dengue haemorrhagic fever and dengue shock syndrome. Dengue Bull. 27:138-143.
 
Chuansumrit A, Chaiyaratana W (2014). Hemostatic derangement in dengue hemorrhagic fever. Thrombo. Res. 133(1):10-6.
Crossref
 
Cifu A (2008). Dengue. Available at: http://unhicago/~adamcifu/dengue1.htm
 
Firkin F, Chesterman C, Penington D, Rusha B (1996). de Grouchy's Clinical Haematology in Medical Practice. 5th ed. India: Blackwell Science p 360.
 
Gubler DJ (2002). The global emergence/resurgence of arboviral disease as public health problem. Arch. Med. Res. 33:330-342.
Crossref
 
Gunawan S, Sutanto FC, Tatura S, Mantik MF (2010). Platelet Distribution Width dan Mean Platelet Volume: Hubungan dengan Derajat Penyakit Demam Berdarah Dengue. Sari Pediatr. 12(2):74- 7.
 
Handian RI (2001). Bleeding and Thrombosis. Harrison principles of internal medicine. 15th ed. McGraw Hill. USA.
 
Huan YL, Yeh TM, Liu HS, Lin YS, Chen SH et al (2001). Immunopathogenesis of dengue virus infection. J. Boimed. Sci. 8: 377-388.
Crossref
 
Hyams KC, Oldfield EC, Scott RM, Bourgeois AL, Gardiner H, Pazzaglia G, Moussa M, Saleh AS, Dawi OE, Daniell FD (1986). Evaluation of febrile patients in Port Sudan, Sudan: isolation of dengue virus. Am. J. Trop. Med. Hyg. 35(4):860-5.
Pubmed
 
Jameel T, Mehmood K, Mujtaba G, Choudhry N, Afzal N, Paul RF (2012). Changing Haematological parameters in dengue viral infections. J. Ayub Med. Coll. Abbotabad 24(1):3-6.
Pubmed
 
Karoli R, Fatima J, Siddiqi Z, Kazmi KI, Sultania AR (2012). Clinical profile of dengue infection at a tertiary hospital in north India. J. Infect. Dev. Ctries. 6(7):551-554.
Crossref
 
Khan E, Siddiqui J, Shakoor S, Mehraj V, Jamil B, Hasan R (2007). Dengue outbreak in Karachi, Pakistan, 2006: experience at atertiary care centre. Trans. R Soc. Trop. Med. Hyg. 101:1114-9.
Crossref
 
Khan R, Zaheer MS, Khan T, Quaiser S, Rabbani MU (2011). Profile of Dengue Patients in a North Indian Referral Hospital. JIACM 12(3): 179-81.
 
Lin CF, Lei HY, Liu CC, Liu HS, Yeh TM, Wang ST, Yang TI, Sheu FC, Kuo CF, Lin YS (2001). Generation of IgM antiplatelet autoantibody in dengue patients. J. Med. Virol. 63(2):143-9.
Crossref
 
Malik A, Earhart K, Mohareb E, Saad M, Saeed M, Ageep A, Soliman A (2011). Dengue hemorrhagic fever outbreak in children in Port Sudan. J. Infect. Public Health 4(1):1-6.
Crossref
 
Natth B (1993). Pathology of dengue haemorrhagic fever: In monograph on dengue and dengue haemorrhagic fever. SERO Regional Publication, New Delhi 22:72-9.
 
Nimmamnitya S (1999). Dengue Hemorrhagic fever: Disorders of Hemostasis. IX congress of the International Society of Haematology Asia-Pacific Division. Bangkok, Thailand pp. 185-187.
 
Noisakran S, Dechtawewat T, Avirutnan P, Kinoshita T, Siripanyaphinyo U, Puttikhunt C, Kasinrerk W, Malasit P, Sittisombut N (2008). Association of dengue virus NS1 protein with lipid rafts. J. Gen. Virol. 89:2492-2500.
Crossref
 
Orsi FA, Angerami RN, Mazetto BM, Quaino SK, Santiago-Bassora F, Castro V, de Paula EV, Annichino-Bizzacchi JM (2013). Reduced thrombin formation and excessive fibrinolysis are associated with bleeding complications in patients with dengue fever: a case-control study comparing dengue fever patients with and without bleeding manifestations. BMC Infect. Dis. 13:350.
Crossref
 
Saito M, Oishi K, Inoue S, Dimaano EM, Alera MT, Robles AM, Estrella BD Jr, Kumatori A, Moji K, Alonzo MT, Buerano CC, Matias RR, Morita K, Natividad FF, Nagatake T (2004). Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. Clin. Exp. Immunol. 138(2):299-303.
Crossref
 
Saxena R, Pati HP, Mahapatra M (2011). Recent Advances in Hematology. 3ed. Jaypee Brothers Medical Publishers (P) Ltd.
Crossref
 
Schexneider KI, Reedy EA (2005). Thrombocytopenia in dengue fever. Curr. Hematol. Rep. 4(2):145-8.
Pubmed
 
Shivbalan S, Anandnathan K, Balasubramanian S, Datta M, Amalraj E (2004). Predictors of spontaneous bleeding in Dengue. India J. Pediatr. 71:33-6.
Crossref
 
Sugianto D, Samsi TK, Wulur H, Dirgagunsa SA, Jenning GB (1994). The changes of platelet count in dengue haemorrhagic fever. Cermin Dunia Kedokteran 92:14-7.
 
Sun DS, King CC, Huang HS, Shih YL, Lee CC, Tsai WJ, Yu CC, Chang HH (2007). Anitplatelet autoantibodies elicit by dengue virus non-structrual Protein 1 cause thrombocytopenia and mortality in mice. J Thromb. Haemost. 5:2291-2299.
Crossref
 
Sung V, O'Brien DP, Matchett E, Brown GV, Torresi J (2003). Dengue fever in travels returning from Southeast Asia. J. Travel Med. 10(4): 208-13.
Crossref
 
Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I (2010). Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 14(1):28-32.
Pubmed
 
Wang S, He R, Patarapotikul J, Innis BL, Anderson R (1995). Antibody-enhanced binding of dengue-2 virus to human platelets. Virology 213(1):254-257.
Crossref
 
World Health Organization (1997). Dengue haemorrhagic fever: Diagnosis, treatment and control. 2nd ed., WHO, Geneva.
 
World Health Organization (2012). Dengue and Severe Dengue. Fact sheet, Nº 117 http://www.who.inf/mediacentral/factsheets/fs117/en/

 


APA Bashir, A. B.,* Mohammed, B. A., Saeed, O.K., & Ageep, A. K. (2015). Thrombocytopenia and bleeding manifestations among patients with dengue virus infection in Port Sudan, Red Sea State of Sudan. Journal of Infectious Diseases and Immunity, 7(2), 7-13.
Chicago Bashir, A.B., Mohammed, B.A., Saeed, O.K. and Ageep, A.K.. "Thrombocytopenia and bleeding manifestations among patients with dengue virus infection in Port Sudan, Red Sea State of Sudan." Journal of Infectious Diseases and Immunity 7, no. 2 (2015): 7-13.
MLA Bashir, et al. "Thrombocytopenia and bleeding manifestations among patients with dengue virus infection in Port Sudan, Red Sea State of Sudan." Journal of Infectious Diseases and Immunity 7.2 (2015): 7-13.
   
DOI 10.5897/JIDI2014.0143
URL http://academicjournals.org/journal/JIDI/article-abstract/654ED6852558

Subscription Form