Journal of Infectious Diseases and Immunity
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Article Number - E6CBABB61857


Vol.8(2), pp. 10-17 , November 2016
DOI: 10.5897/JIDI2016.0163
ISSN: 2141-2375



Full Length Research Paper

Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria



Hien S.
  • Hien S.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar
Yeboah O. R.
  • Yeboah O. R.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar
Adou H.
  • Adou H.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar
N'Guessan K.
  • N'Guessan K.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar
Kouacou A. P. V.
  • Kouacou A. P. V.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar
Dassé S. R.
  • Dassé S. R.
  • Laboratory of Immunology and Allergology, Faculty of Medical Sciences, Félix Houphouët Boigny University-Cocody, Ivory Coast.
  • Google Scholar







 Received: 29 September 2016  Accepted: 24 November 2016  Published: 30 November 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Measurement of C reactive protein rate in children suffering from falciparum malaria was done in order to determine its relationships according to parasite density, white blood cells, age and hemoglobin. This study was a prospective cross-sectional with descriptive and analytical purpose. It focused on 50 children aged from 0 to 15 years admitted in the Pediatric departments of university hospitals in Cocody and Treichville for malaria (Abidjan). Venous blood samples were collected on ethylenediaminetetraacetic acid (EDTA) for blood cells count, parasite density and identification of Plasmodium falciparum. The samples, collected without EDTA were used to measure C Reactive Protein. With the blood collected, the serum was processed on the same day and preserved at -20°C. Giemsa-stained thin and thick blood films were analyzed by microscope for plasmodium species and parasite densities. Hematological parameters were determined using hematology cell counter. Turbidimetric test was used for quantitative detection of C Reactive Protein. Statistical analysis was carried out using SPSS (Statistical Package for Social Science) Version 18.0 and Excel 2007. For all test p-value <0.05 below was considered significant. High levels of C reactive protein were observed in all of patients. Younger children had higher C-reactive protein (CRP) level. Positive strong correlation was noted between CRP and both parasite density and leukocytes. There was negative correlation between C reactive protein rate and age. In children suffering from severe anemia, the negative correlation observed between CRP and hemoglobin level was stronger than those suffering from moderate anemia. The main finding of this study was the involvement of CRP in malaria anemia. The levels of CRP according to age in children with falciparum malaria could be used as a biomarker for assessing anemia.

Key words: Falciparum malaria, C reactive protein (CRP), children.

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APA Hien, S., Yeboah, O. R., Adou, H., N'Guessan, K., Kouacou, A. P. V., & Dassé, S. R. (2016). Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria. Journal of Infectious Diseases and Immunity, 8(2), 10-17.
Chicago Hien S., Yeboah O. R. , Adou H., N&#;Guessan K., Kouacou A. P. V. and Dass&e S. R.. "Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria." Journal of Infectious Diseases and Immunity 8, no. 2 (2016): 10-17.
MLA Hien S., et al. "Study about relationship between C-reactive protein (CRP) and other indicators in children with malaria." Journal of Infectious Diseases and Immunity 8.2 (2016): 10-17.
   
DOI 10.5897/JIDI2016.0163
URL http://academicjournals.org/journal/JIDI/article-abstract/E6CBABB61857

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