Journal of Medical Genetics and Genomics
Subscribe to JMGG
Full Name*
Email Address*

Article Number - 11E1D288995


Vol.4(2), pp. 13 - 24 , March 2012
DOI: 10.5897/JMGG11.022
ISSN: 2141-2278



Review

Teeth are bones: Signature genes and molecules that underwrite odontogenesis


Kazhila C. Chinsembu




Department of Biological Sciences, Faculty of Science, University of Namibia, P/Bag 13301, Windhoek, Namibia


Email: kchinsembu@unam.na






 Accepted: 02 March 2012  Published: 31 March 2012

Copyright © 2012 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Understanding the molecular genetics of odontogenesis (tooth development) can unlock innovative avenues to genetically engineer teeth for therapy. In this review, emerging insights into the genetic and molecular bases of tooth development are presented. Four conserved signature genes express master molecules (fibroblast growth factors, bone morphogenetic proteins, wingless integrated ligands and sonic hedgehog protein) that underwrite odontogenesis. Five homeobox genes (Barx1, Dlx, Pax9, Msx and Pitx) and many secondary molecules (notably transcription factors) mediate signalling pathways that drive tooth initiation, morphogenesis and differentiation. The role of at least 57 genes and signalling molecules are presented in this work.

 

Key words: Genes, signalling molecules, odontogenesis.


APA (2012). Teeth are bones: Signature genes and molecules that underwrite odontogenesis. Journal of Medical Genetics and Genomics, 4(2), 13 - 24.
Chicago Kazhila C. Chinsembu. "Teeth are bones: Signature genes and molecules that underwrite odontogenesis." Journal of Medical Genetics and Genomics 4, no. 2 (2012): 13 - 24.
MLA Kazhila C. Chinsembu. "Teeth are bones: Signature genes and molecules that underwrite odontogenesis." Journal of Medical Genetics and Genomics 4.2 (2012): 13 - 24.
   
DOI 10.5897/JMGG11.022
URL http://academicjournals.org/journal/JMGG/article-abstract/11E1D288995

Subscription Form