Journal of
Medical Genetics and Genomics

  • Abbreviation: J. Med. Genet. Genomics
  • Language: English
  • ISSN: 2141-2278
  • DOI: 10.5897/JMGG
  • Start Year: 2009
  • Published Articles: 48

Case Report

Co-inheritance ααα anti 3.7 triplication with hemoglobin D/β0 thalassemia: A case report from South-west Iran

B. Keikhaei1, H. Galehdari2 and B. Salehi3
1Research center for Thalassemia and Hemoglobinopathy of Jondishapour University of Medical Science, Ahvaz, Iran. 2Department of Genetics, Shahid Chamran University, Research Center for Thalassemia and Hemoglobinopathy Ahwaz, Iran. 3Shafa Hospital, Kerman, Iran.
Email: [email protected]

  • Article Number - AC79B545778
  • Vol.2(2), pp. 18-23, April 2010
  •  Accepted: 16 February 2010
  •  Published: 30 April 2010

Abstract

Hemoglobin D [Hb D] is the second most common hemoglobin variant in South west of Iran. It places in second position after hemoglobin S. So far up to present, from the genetic point of view, all cases of Hb D are hemoglobin Punjab. Hb D, in all forms, heterozygote, homozygote and compound heterozygote presents with mild anemia or completely asymptomatic that may be discovered accidentally. There was a case presentation of a child with genotype of Hb D/β0 thalassemia co-inherited with ααα anti 3.7 triplication and phenotype of moderate to severe anemia similar to thalassemia intermediate.

 

Key words: Hb D-Punjab, ααα anti 3.7 triplication, South west of Iran.

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