March 2012

Teeth are bones: Signature genes and molecules that underwrite odontogenesis

Understanding the molecular genetics of odontogenesis (tooth development) can unlock innovative avenues to genetically engineer teeth for therapy. In this review, emerging insights into the genetic and molecular bases of tooth development are presented. Four conserved signature genes express master molecules (fibroblast growth factors, bone morphogenetic proteins, wingless integrated ligands and sonic hedgehog protein)...

Author(s): Kazhila C. Chinsembu

March 2012

Evaluation of methylenetetrahydrofolate reductase C677T gene polymorphism associated risk factor in the patients of recurrent pregnancy loss

The etiology of human recurrent fetal loss is associated with methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism. Several conflicting reports on MTHFR gene polymorphism increases the curiosity, with the aims to evaluate the prevalence of MTHFR gene in recurrent miscarriage cases using PCR-RFLP analysis. The present findings reveal that the highest (26.7%) incidence was observed in heterozygote (CT)...

Author(s): Ajit K Saxena, S Pandey and LK Pandey